2013 American Transplant Congress
Post Transplant Outcomes in Elderly Renal Transplant Recipients
Nephrology, Henry Ford Hospital, Detroit, MI
The choice of induction therapy in elderly renal transplant population is generally based on experience from general renal transplant recipient (RTR) population. It is uncertain…2013 American Transplant Congress
Development of a Clinically Relevant Conditioning Regimen Using Available Costimulatory Blockade Reagents for Induction of Renal Allograft Tolerance Via Mixed Hematopoietic Chimerism
Transplant Center, Massachusetts General Hospital, Boston, MA
Background: We have previously reported that costimulation blockade (CB) with anti-CD154 mAb (mAb154) promotes mixed chimerism and renal allograft tolerance in nonhuman primates. However, this…2013 American Transplant Congress
Increasing the Accuracy of Mycophenolic Acid Exposure Estimation in Heart Transplants Using 3 Predictive Tools
Purpose: Mycophenolic acid (MPA) area under the curve (AUC) has been reported as an important marker of graft outcome. Pharmacokinetic (PK) tools for the MPA…2013 American Transplant Congress
Differences between Live and Deceased-Donor Kidney Transplantation in a Centre Performing Protocol Biopsies
Department of Nephrology, Hannover Medical School, Hannover, Germany
Background: Live kidney transplantation (LK-tx) results in a longer transplant survival and better renal function than non-living transplantation (Non-LK-tx).Methods: We tested the reasons for that…2013 American Transplant Congress
Modulating T Cell Migration in the Postischemic Liver: Hepatic Stellate Cells as New Therapeutic Target?
Department of Surgery-Grosshadern, University of Munich, Munich, Germany
Background: CD4+ T cells play a critical role during hepatic ischemia-reperfusion (I/R) injury although the mechanisms of their migration in the postischemic liver in remain…2013 American Transplant Congress
Human Microbiota Characterization in the Course of Renal Transplantation
BACKGROUND: The human microbiota comprises all microbes associated with the human body and could play an important role for transplant recipient health. It may serve…2013 American Transplant Congress
CD3 Antibody-Induced Transplant Tolerance Relies on In Situ TGF-Beta and PD-1 Signaling in T Cells
CD3 antibody therapy, successfully used to treat patients with recent onset type 1 diabetes, can restore self-tolerance to autoantigens. We extented these tolerogenic properties to…2013 American Transplant Congress
Decreasing Incidence of New-Onset Diabetes after Kidney Transplantation
Directorate of Nephrology and Transplantation, University Hospital of Wales, Cardiff, United Kingdom
Aim: The incidence of new-onset diabetes after kidney transplantation (NODAT) is largely influenced by immunosuppressive drugs. There is some evidence that its incidence is lower…2013 American Transplant Congress
Acute Rejection on Surveillance Biopsies Is a Predictor of Functional Decline in Kidney Transplants over Long-Term Follow-Up
Background: Identifying specific factors that are predictive of renal allograft functional decline is important toward prolonging graft survival. Few studies have addressed specific histologic diagnoses…2013 American Transplant Congress
Problems and Pitfalls in Calculation of “True” Treg Numbers Using Assays of Foxp3 TSDR Demethylation in PBMC of Transplant Recipients
FOXP3 is the master transcription factor of CD4+CD25+FOXP3+ T-regulatory (Treg) cells, and demethylation of the Treg-specific demethylation region (TSDR) of FOXP3 is considered a specific…
American Transplant Congress abstracts