2013 American Transplant Congress
Phenotypic Classification of Acute Rejection Correlates with Long-Term Graft Survival
U of Cincinnati, Cincinnati; Christ Hospital, Cincinnati
Effect of acute rejection (AR) type (antibody versus cellular versus mixed) and timing (early vs. late) on graft survival have not been concomitantly analyzed. This…2013 American Transplant Congress
Antibodies to K-α1 Tubulin and IL 17 Induces Periostin Dependent Pro-Fibrotic Signaling Cascades: A Novel Biomarker Involved in the Pathogenesis of Chronic Lung Allograft Rejection
Surgery, Medicine, Pathology & Immunology, Washington University School of Medicine, St. Louis, MO
Background: Antibodies (Abs) to K-Α1-tubulin (KΑ1T), an epithelial gap junction cytoskeletal protein, and Interleukin (IL)-17, have been implicated in the pathogenesis of bronchiolitis obliterans syndrome…2013 American Transplant Congress
Liver Transplant for NASH: We Need To Spare the Nephron!
Pharmacy, MUSC, Charleston, SC; Transplant, MUSC, Charleston, SC
Background: The aim of this study was to evaluate outcomes of patients transplanted for NASH cirrhosis compared to those without NASH.Methods: Single center retrospective longitudinal…2013 American Transplant Congress
Iothalamate Urinary Clearance May Be Unreliable: A Comparison to Modification of Diet in Renal Disease in Renal Transplant Patients
Purpose: The gold standard of measuring glomerular filtration rate (mGFR) is to calculate the urinary clearance of exogenous markers, such as iothalamate (CLIO), yet such…2013 American Transplant Congress
Antagonists of Bone Morphogenetic Protein Signaling Promote Liver Regeneration and Repair in Mice
The Transplant Center and Department of Surgery, Vanderbilt University Medical Center, Nashville, TN
Pharmacologic agents to enhance liver recovery after injury would have wide therapeutic application. Based on previous work suggesting Bone Morphogenetic Protein (BMP) signaling modulates liver…2013 American Transplant Congress
Donor Factors Similarly Impact Survival Outcome after LT in HCC and Non-HCC Patients
Introduction: Many have advocated the preferential use of high risk allografts for hepatocellular carcinoma (HCC) patients undergoing liver transplantation (LT). HCC patients tend to have…2013 American Transplant Congress
In Vivo Depletion of CD8+ and αβTCR+ Cells Overcomes the Rejection of Vascularized Composite Tissue Allotransplant in Sensitized Recipients
Institute for Cellular Therapeutics, University of Louisville, Louisville, KY
Sensitization, a state of the presence of donor-specific antibody (DSA) in recipient, has usually been considered an absolute contraindication to solid organ transplantation. Currently, the…2013 American Transplant Congress
Anti-TIM-4 Mediates Long-Term Engraftment of Islet Allografts by Promoting IL-10 Expression by TIM-1+ Bregs and Inhibiting IFNγ Expression by Proinflammatory “Be1” B Cells
University of Pittsburgh, Pittsburgh; Harvard Medical School, Boston
We recently defined TIM-1 as an inclusive marker for IL-10 expressing regulatory B cells (Bregs). Moreover, Α-TIM-1 mAb prolongs allograft survival (GS) through induction of…2013 American Transplant Congress
FL/G-CSF/AMD3100 Mobilized Hematopoietic Stem Cells Induce Mixed Chimerism with Nonmyeloablative Conditioning and Transplantation Tolerance without GVHD
Institute for Cellular Therapeutics, University of Louisville, Louisville, KY
Mobilized hematopoietic stem cells (HSC) now serve as a major source for transplantation. Better mobilizing approaches are clinically important. AMD3100, a CXCR4 competitive inhibitor, has…2013 American Transplant Congress
Favorable Post-Transplant Survival for Liver Transplant Recipients with Treated Porto_Pulmonary Hypertension
Background: Portopulmonary hypertension (PPH) was once considered an absolute contraindication for liver transplantation (LT) because of associated high peri- and postoperative mortality rates. With evolution…
American Transplant Congress abstracts