2013 American Transplant Congress
Neurokinin-1 Receptor-Signaling of T Cells and Dendritic Cells Is Required for Optimal Elicitation of the T-Cell Response That Leads to Graft Rejection
Increasing evidence suggests that elicitation of donor–reactive T-cell immunity is regulated by pro-inflammatory neuropeptides. Substance P (SP) is the prototypic pro-inflammatory neuropeptide released by leukocytes…2013 American Transplant Congress
Extended-Release Tacrolimus Therapy Is Effective and Safe in De Novo Kidney Transplant Recipients from Living and Expanded, Standard, or after Cardiac Death Deceased Donors
Nephrology, Hospital 12 de Octubre, Madrid, Spain
Nonadherence is one of the most important causes of late renal graft loss. A single daily dose of tacrolimus in the morning beginning immediately after…2013 American Transplant Congress
MFI TRAP: HLAmatchmaker Can Help To Do the Reactions Patterns of DSA Versus NDSA To Assess Risk of Graft Failure by AMR, THE
The HLAMatchmaker (HLAMM) evaluates the compatibility between donor and recipient through comparisons within and between loci, and determines which epitopes in HLA mismatched are different…2013 American Transplant Congress
Glomerular microRNA Expression Profiles in Transplant-Associated Thrombotic Microangiopathy
Thrombotic microangiopathy is a serious complication of renal transplantation. Besides recurrence of the primary disease (RecTMA) renal transplant-associated thrombotic microangiopathy (rTx-TMA) can emerge de novo…2013 American Transplant Congress
Pregnancy Outcomes in Solid Organ Transplant Recipients with a Switch from a Mycophenolic Acid Product to Azathioprine Prior to Conception
The purpose of this study was to analyze pregnancy outcomes in female transplant recipients who switched their immunosuppressive regimen from a mycophenolic acid product (MPA)…2013 American Transplant Congress
Anti-IL6R Suppresses Primary IgM Response and CD5+ B-1a Cell Subset Stimulated by HLA.A2+ Skin Allografts
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
Background Inhibition of IL-6/IL-6R signaling using anti-IL6R monoclonal antibody is effective in attenuating donor-specific antibody (DSA) responses to skin allografts in a mouse model. Here,…2013 American Transplant Congress
Defining pp65 Enemia and qPCR Cut-Offs for Pre-Emptive Therapy of CMV Disease in Low-Risk, Seropositive Renal Transplanted Recipients
Renal Transplant Service, University of São Paulo School of Medicine, Sao Paulo, Brazil
CMV disease mostly invasive gastro-intestinal with low viremia occurs in approximately 16% of CMV seropositive renal transplant recipients not receiving Thymoglobuline (ATG). Pre-emptive therapy (PETh)…2013 American Transplant Congress
Bone Marrow and Adipose Tissue Derived Mesenchymal Stem Cells Induce HLA-Specific Lysis by CD8+ T Cells
IntroductionMesenchymal Stem Cells (MSC) are an interesting cell therapy for clinical organ transplantation and are usually isolated from bone marrow (BM-MSC) or adipose tissue (A-MSC)…2013 American Transplant Congress
Influence of Recipient Cytochrome P450 3A5 Polymorphism on the Metabolism of Advagraf Administered De Novo after Renal Transplantation
Advagraf (Adv), a prolonged release formulation of tacrolimus (tac), allows once-a-day administration and improves medication adherence.Patients (pts) possessing at least one CYP3A5*1 allele have an…2013 American Transplant Congress
Age and Antimetabolites: Appropriate Candidate Selection Drives Success
Pharmacy, Barnes-Jewish Hospital, St. Louis, MO; Medicine, Washington University, St. Louis, MO
Background:Early studies comparing mycophenolate (MMF) to azathioprine (AZA) post-renal transplant demonstrated superiority of MMF over AZA for the prevention of acute rejection (AR), with no…
American Transplant Congress abstracts