ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    Immune Suppressant Effect of Erythropoietin Alpha on Human Allo-Reactive T Cell Responses

    J. Manrique, P. Cravedi, P. Heeger, A. Mehrotra

    Renal Division, Department of Medicine, Mount Sinai, New York

    Recent clinical studies showed that complete correction of anemia with erythropoietin (EPO) therapy improves human kidney transplant outcomes, but mechanisms underlying this protective effect are…
  • 2013 American Transplant Congress

    2B4 Induced by Selective CD28 Blockade Functionally Regulates Alloreactive Memory CD8+ T Cell Responses

    D. Liu, S. Krummey, S. Suchard, S. Nadler, M. Ford

    Emory Transplant Center, Emory University, Atlanta, GA; Bristol-Myers Squibb, Princeton, NJ

    Studies in both murine and NHP models have shown that CTLA-4Ig-resistant rejection is mediated by CD8+ T cells, particularly memory CD8+ T cells. Because CTLA-4…
  • 2013 American Transplant Congress

    Tuberculosis in Kidney Transplant – 10 Years Experience

    L. Viana, M. Cristelli, M. Tavares, M. Dantas, C. Felipe, N. Oliveira, M. Paula, S. Miranda, M. Franco, H. Tedesco, J. Medina- Pestana

    Nephrology Division, Hospital do Rim e Hipertensão, Sao Paulo, Brazil

    Introduction: Tuberculosis infection (TB) increases morbidity and mortality after kidney transplantation (TX) and poses diagnostic and therapeutic challenges. The incidence of TB among solid organ…
  • 2013 American Transplant Congress

    HLA Antibody Increase Associated with Cardiac Surgery

    P. Warner, G. Aldea, M. Gallagher, K. Nelson

    Immunogenetics/HLA, Puget Sound Blood Center, Seattle, WA; Adult Cardiac Surgery, University of Washington Medical Center, Seattle, WA

    Increases in titer or de novo production of HLA antibody are potential sequelae of pregnancy, transfusion, or transplantation. It has also been reported that pro-inflammatory…
  • 2013 American Transplant Congress

    Using Non-Invasive, Real-Time Imaging Technology To Assess the Status of Donor Kidneys

    J. Verbesey, M. Cooper, A. Peter, R. Derek, P. Moody, Y. Chen

    MedStar Georgetown Transplant Institute, Washington, DC; Fischell Department of Bioengineering, University of Maryland, College Park, MD

    Purpose. The extent of acute tubular necrosis (ATN) in renal tubules may provide valuable prognostic data regarding post-transplant renal function of donor kidneys. We used…
  • 2013 American Transplant Congress

    Nutraceuticals Extenuate Kidney Ischemia/Reperfusion Injury in Rats Via HO-1 Induction

    P. Gehwolf, F. Struller, A. Kostron, M. Wolzt, B. Wegiel, J. Pratschke, R. Öllinger

    Universitätsklinik für Visceral-, Transplant- und Thoraxchirurgie, Medical University Innsbruck, Innsbruck, Austria; Universitätsklinik für Klinische Pharmakologie, Medizinische Universität Wien, Vienna, Austria; Department of Surgery, Transplant Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston

    Background: The induceable Hemeoxygenase-1 (HO-1) is the rate limiting step in the conversion of heme into biliverdin, carbon monoxide (CO) and free iron (Fe2+). Up-regulation…
  • 2013 American Transplant Congress

    Proteinkinase C Alpha Contributes to Impairment of Renal Blood Flow and Inflammation in Hypoxia Induced Renal Ischemia Reperfusion Injury (IRI)

    D. Walacides, N. Rüskamp, R. Song, K. Hueper, M. Mengel, M. Meier, H. Haller, M. Schiffer, F. Gueler

    Nephrology, Medical School Hannover, Hannover, Germany; Radiology, Medical School Hannover, Hannover, Germany; Applied Genomics Center, University of Alberta, Edmonton, Canada; Cental Animal Facility, Medical School Hannover, Hannover, Germany

    Background – Renal ischemia reperfusion injury (IRI) leads to delayed graft function (DGF) after kidney transplantion and contributes to acute transplant rejection as well as…
  • 2013 American Transplant Congress

    Association between Early Progression in Chronic Kidney Disease Stage Following Liver Transplantation and Graft Survival

    W. Irish, P. Massa, M. Tran, P. Bernhardt, J. Ricci

    CTI Clinical Trial and Consulting Svcs, Raleigh; Novartis Pharmaceuticals Corporation, East Hanover; Novartis Pharma AG, Basel, Switzerland; Wellmera AG, Basel, Switzerland

    Introduction: Renal dysfunction before and after liver transplantation is a significant predictor of graft survival (GS). This study aims to characterize the relationship between early…
  • 2013 American Transplant Congress

    Prolonged Delayed Graft Function Is Associated with Inferior Patient and Kidney Allograft Survivals

    T. Sandes-Freitas, R. Klein, H. Tedesco, J. Medina- Pestana

    Nephrology Division, Hospital do Rim e Hipertensão, São Paulo, Brazil

    Introduction: The incidence of delayed graft function (DGF) is variable according to donor/recipients demographics. It is still unclear the influence of DGF on clinical outcomes…
  • 2013 American Transplant Congress

    Chimeric Antibody Against LFA-1 Does Not Synergize with Belatacept in Primate Renal Transplantation, A

    D. Anderson, F. Leopardi, N. Turgeon, E. Strobert, J. Jenkins, R. Wang, K. Reimann, C. Larsen, A. Kirk

    Emory Transplant Center, Atlanta, GA; Yerkes National Primate Research Center, Atlanta, GA; Beth Israel Deaconess Medical Center, Boston, MA

    Background: Clinical studies with belatacept have shown improved graft function at the cost of increased rates of and more severe early rejection. Blockade of LFA-1…
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