ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    Everolimus-Facilitated Reduction of Tacrolimus in De Novo Liver Transplant Recipients Achieves Comparable Overall Efficacy with Fewer Biopsy-Proven Acute Rejections Versus Standard Tacrolimus: 24-Month Results of a Randomized Trial

    J. Fung, K. Chavin, Y. Moysyuk, S. Orloff, S. Yantorno, R. Jones, P. Neuhaus, G. Dong, P. Lopez, G. Junge, F. Nevens

    For the H2304 Study Group, Cleveland; Novartis Pharmaceuticals Corporation, New Jersey; Novartis Pharma AG, Basel, Switzerland

    Purpose: The H2304 (NCT00622869) study compared the efficacy and safety of concentration-controlled everolimus (EVR) to eliminate or to reduce tacrolimus (TAC) vs standard TAC (TAC-C)…
  • 2013 American Transplant Congress

    Lack of Clinical Factors Increasing Quantitative Interstitial Fibrosis after Renal Transplantation under a Lower Target Trough Strategy of Tacrolimus

    N. Komine, S. Satoh, K. Numakura, M. Saito, T. Inoue, S. Narita, Y. Miura, N. Tsuchiya, H. Kagaya, M. Miura, T. Habuchi

    Urology, Akita University, Akita, Japan; Division of Renal Replacement Therapeutic Science, Akita University, Akita, Japan; Pharmacy, Akita University, Akita, Japan

    INTRODUCTION AND OBJECTIVES: Chronic allograft injury is a multi-factorial process based on immunologic and non-immunologic factors. Patients with the CYP3A5*3/*3 genotype (non-expressers) require a lower…
  • 2013 American Transplant Congress

    Prospective and Randomized Trial Comparing Tacrolimus Versus Sirolimus after Simultaneous Pancreas-Kidney Transplantation

    D. Cantarovich, E. Papuchon, G. Blancho, J. Dantal, M. Giral, J. Branchereau, G. Karam

    Institut de Transplantation-Urologie-Néphrologie, Nantes University Hospital, Nantes, France

    Introduction. Minimizing or sparing potentially nephrotoxic and diabetogenic immunosuppressants could represent an advantage following simultaneous pancreas-kidney transplantation (SPK-Tx).Purpose. We report here the actual one-year result…
  • 2013 American Transplant Congress

    Variability of IMPDH-Activity in Long-Term MPA Mediated Immunosuppression

    D. Abendroth, M. Marzinzig, M. Stangl

    Center of Surgery, University of Ulm, Ulm, Germany; Visceral and Transplant Surgery, Ludwig-Maximilians-Universität, Munich, Germany

    Purpose of this study was to examine wether the long term exposure for mycophenolate mofetil (MMF) or enteric coated form (EC-MPS) is leading to an…
  • 2013 American Transplant Congress

    Suppression of Acute Rejection by Administration of Prostaglandin E2 Receptor Subtype 4 (EP4) Agonist in a Rat Heterotopic Small Bowel Transplantation Model

    T. Okamoto, R. Tamura, S. Okamoto, Y. Fujimoto, Y. Tabata, S. Uemoto

    Department of Surgery (HBP&Transplantation), Kyoto University, Graduate School of Medicine, Kyoto, Japan; Field of Tissue Engineering, Kyoto University, Institute of Frontier Medical Science, Kyoto, Japan

    Background: Prostaglandin E2 (PGE2)–PGE2 receptor subtype 4 (EP4) signaling is known to modulate the inflammation process. Several studies have demonstrated the potential utility of EP4-selective…
  • 2013 American Transplant Congress

    Kidney Injury Molecule-1 and Osteopontin: New Markers for Prediction of Early Kidney Transplant Rejection

    Z. Jin, P. Tian, W. Xue, C. Ding, J. Zheng, T. Mao, W. Duan, M. Xi

    Department of Kidney Transplantation, Hospital of Nephropathy, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China

    Background. Kidney injury molecule-1 (KIM-1) and osteopontin (OPN) play important roles in immune regulation. We hypothesized that serum KIM-1 and OPN might serve as biomarkers…
  • 2013 American Transplant Congress

    Health-Related Quality of Life and Adherence to Medication in Kidney Transplantation: A Longitudinal Analysis

    F. Ortiz, R. Roine, R. Malmström, P. Koskinen

    Nephrology, Helsinki University Hospital, Helsinki, Finland; Group Administration, Helsinki University Hospital, Helsinki, Finland; Internal Medicine, Helsinki University Hospital, Helsinki, Finland

    AimTo analyse the influence of dialysis type on adherence to immunosupressive medications (IS) and HRQoL before and after KT.Material and Methods. Between years 2004-2008 156…
  • 2013 American Transplant Congress

    Impact of Vitamin D, Bisphosphonate, and Combination Therapy on Bone Mineral Density in Kidney Transplant Patients

    H. Jeon, M. Han, J. Jeong, Y. Kim, H. Kwon, T. Koo, M. Kim, H. Ro, C. Ahn, J. Yang

    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Transplantation Center, Seoul National University Hospital, Seoul, Republic of Korea; Department of Internal Medicine, Korea University Medical Center, Seoul, Republic of Korea; Department of Internal Medicine, Gachon University of Medicine and Science, Inchon, Republic of Korea; Transplantation Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea

    Background: Osteoporosis can develop and become aggravated in a large number of kidney transplant patients; however, the best preventive options for post-transplant osteoporosis remain controversial.Methods:…
  • 2013 American Transplant Congress

    Utility of Serial Allograft Biopsies (AGBx) during Delayed Graft Function (DGF) in Renal Transplantation, The

    H. Hatoum, A. Patel, K. Venkat

    Renal Transplant Center, Henry Ford Hospital, Detroit, MI

    Background: DGF complicates approximately 30% of deceased donor (DD) kidney transplants and rarely also occurs following live donor (LD) kidney transplants (KTX). KTX in DGF…
  • 2013 American Transplant Congress

    Change of Single-Kidney Glomerular Filtration Rate in Kidney Donors after Kidney Donation, The

    G. An, B. Chung, J. Kim, I. Moon, C. Park, Y. Kim, C. Yang, B. Choi

    Transplant Research Center, Seoul St. Mary's Hospital, College of Medicine,The Catholic University of Korea, Seoul, Korea; Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea; Department of Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea

    Background: It is well known that remaining nephrons after loss of renal tissue showed compensatory hyperfiltration in chronic kidney disease. But in healthy populations without…
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