Abstracts Archive - Page 163 of 1683 - ATC Abstracts

2022 American Transplant Congress
IL-15 Signaling is Required for the Maintenance of Tissue Resident Memory T Cells in Chronic Allograft Rejection
R. Tieu¹, Q. Zeng¹, D. Zhao¹, A. Williams¹, J. Yun Tso², F. Lakkis¹, J. Yun Tso²
¹Starzl Transplantation Institute, Pittsburgh, PA, ²JN Biosciences, Mountain View, CA
*Purpose: Currently, no immunotherapies have been clinically proven to prevent or treat chronic rejection. IL-15 is known to support memory T cell homeostasis. However, it…
2022 American Transplant Congress
Histopathology at Diagnosis and One-Year Outcomes in Antibody Mediated Rejection in Pediatric Kidney Transplant Recipients: Preliminary Findings from the Paramour “Pediatric Renal AMR Outcomes” Study
R. Zahr¹, D. Puliyanda², I. Ashoor³, N. Hayde⁴, S. Solomon⁵, R. Engen⁶, L. Harshman⁷, C. Peterson⁸, S. McEwen⁹, A. Jain¹⁰, R. Garro¹¹, A. Mansuri¹², M. Kallash¹³, K. Twombley¹⁴
¹Pediatrics, University of Tennessee Health Science Center, Memphis, TN, ²Cedars-Sinai Med Ctr, West Hollywood, CA, ³Pediatrics, Lousiana State University, New Orleans, LA, ⁴Montefiore Medical Center, Bronx, NY, ⁵The Children's Hospital at Montefiore, New York, NY, ⁶Pediatrics, University of Wisconsin Madison, Madison, WI, ⁷University of Iowa Children's Hospital, Iowa City, IA, ⁸University of Utah, Salt Lake City, UT, ⁹University of Minnesota, Minneapolis, MN, ¹⁰Pediatrics, Wayne State University, Troy, MI, ¹¹Emory University, Atlanta, GA, ¹²Pediatrics, Augusta University, Augusta, GA, ¹³Pediatrics, The Ohio State Univesrity, Columbus, OH, ¹⁴Medical University of South Carolina, Charleston, SC
*Purpose: Antibody mediated rejection (AMR) is a major cause of kidney allograft dysfunction leading to graft loss. There is a paucity of data regarding how…
2022 American Transplant Congress
Impact of Biliary Reconstruction on Tacrolimus Absorption in Pediatric Liver Transplant
M. Chandran¹, D. Yoeli¹, A. Sater², M. Adams¹, F. Karrer¹
¹Children's Hospital Colorado, Aurora, CO, ²University of Colorado, Aurora, CO
*Purpose: Tacrolimus (FK506) oral bioavailability in pediatric liver transplant recipients (LTR) is poor. Enteral FK506 is primarily absorbed in the small intestine and subject to…
2022 American Transplant Congress
Impact of Belatacept on Clinical Outcomes in Lung Transplant Patients with Antibody-Mediated Rejection
L. Zaffiri, R. Hallak, S. Leonard, M. Neely, A. Hulber, H. Berry, K. A. Young, J. M. Reynolds
Duke University, Durham, NC
*Purpose: Antibody-mediated rejection (AMR) is cause of significant morbidity and mortality in lung transplant recipients (LTRs). An optimal therapeutic regimen is still lacking. Recent evidence…
2022 American Transplant Congress
Pretransplant Transcriptome Predicts 24-Month Kidney Function
E. Bardhi¹, K. Archer², D. Maluf¹, J. McDaniels¹, T. Rousselle¹, E. Akalin³, T. Mueller⁴, V. Mas¹
¹University of Maryland School of Medicine, Baltimore, MD, ²Ohio State University, Columbus, OH, ³Montefiore Medical Center, Bronx, NY, ⁴Universityspital Zurich, Zurich, Switzerland
*Purpose: With the development of novel prognostic tools derived from omics technologies, transplant medicine is entering the era of precision medicine, however, there are no…
2022 American Transplant Congress
Critical Care of the Brain-Dead Recipient of a Pig-to-Human Renal Transplant
G. L. Piper¹, P. Sommer², J. M. Stern¹, B. Sullivan¹, E. Weldon¹, N. Lawson¹, B. Lonze¹, R. Dieter², G. Boulton¹, R. Montgomery¹
¹NYU Langone Transplant Institute, New York, NY, ²NYU Langone Health, New York, NY
*Purpose: The care of a brain dead (BD) patient undergoing xenotransplantation in a non-clinical environment poses unique challenges. Selection of an appropriate decedent, stabilization of…
2022 American Transplant Congress
An Interventional Study Using Cell-Mediated Immunity to Guide Primary Prophylaxis for CMV Infection in Organ Transplant Recipients: A Multi-Center Study
J. T. Solera¹, C. Cervera², S. Hosseini¹, J. Gill³, S. Shalhoub⁴, J. Zaltzman⁵, N. Pinzon¹, A. Humar¹, D. Kumar¹
¹UHN, Toronto, ON, Canada, ²UAlberta, Edmonton, AB, Canada, ³UBC, Vancouver, BC, Canada, ⁴LHSC, London, ON, Canada, ⁵StMH, Toronto, ON, Canada
*Purpose: There are limited interventional studies using CMV cell-mediated immunity to guide the duration of antiviral prophylaxis. We aimed to use CMV CMI to guide…
2022 American Transplant Congress
Equivalence of Pediatric Paper and Electronic-Based Patient-Reported Outcome Measures: Findings from a Systematic Review
S. Kortbeek¹, A. Pawaria², V. L. Ng¹
¹Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada, ²Pediatric Hepatology, Gastroenterology and Liver Transplant, Global Hospitals, Mumbai, India
*Purpose: Integration of patient reported outcome measures (PROMs) in routine clinical care reduces utilisation of health care services and improves patient outcomes. Electronic versions of…
2022 American Transplant Congress
Evaluation of Hepatitis C Positive Donor to Hepatitis C Negative Recipient Kidney Transplant in a Highly Sensitized Patient Population
A. T. Iaria, M. Martin, A. Hietpas, I. Tang, S. Koppe, I. Tzvetanov, E. Benedetti, C. Muran
University of Illinois at Chicago, Chicago, IL
*Purpose: This study assessed outcomes of hepatitis C virus (HCV) donor positive to recipient negative (D+/R-) kidney transplants (KT) in high immunologic risk patients. Literature…
2022 American Transplant Congress
Utilizing Microporous Annealed Particle (MAP) Gel as an Immunomodulatory Carrier for Islet Delivery
M. Ma¹, P. Chhabra¹, C. Roosa², D. R. Griffin², K. L. Brayman¹
¹Department of Surgery, University of Virginia Health System, Charlottesville, VA, ²Department of Biomedical Engineering, University of Virginia Health System, Charlottesville, VA
*Purpose: To investigate if coating with MAP gel improves dissociated or whole islet transplantation outcome.*Background: MAP gel platform technology is composed of hydrogel microspheres that…