ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    Optimization of the Coating of Pancreatic Islets with T Regulatory Cells in the Novel Immunoprotective Approach

    K. Golab, S. Kizilel, T. Bal, M. Hara, M. Zielinski, X. Wang, J. Grzanka, L. Wang, O. Cochet, M. Tibudan, P. Witkowski

    Department of Surgery, University of Chicago, Chicago, IL; Department of Chemical and Biological Engineering, College of Engineering, Koc University, Istanbul, Turkey; Department of Medicine, University of Chicago, Chicago, IL

    Aim. T regulatory cells (Tregs) possess immunosuppressive properties and can serve as an effective therapy in transplantation. Recently, we have shown that Tregs can be…
  • 2013 American Transplant Congress

    Tuning the OPTN's KPD Optimization Algorithm To Incentivize Centers To Enter Their "Easy-to-Match" Pairs

    D. Stewart, R. Leishman, E. Sleeman, C. Monstello, G. Lunsford, J. Maghirang, T. Sandholm, S. Gentry, R. Formica, J. Friedewald, K. Andreoni

    UNOS; Carnegie Mellon Univ; Johns Hopkins Univ & USNA; Yale Medical Ctr; Northwestern; Univ of Florida

    Background: Currently, priority points are awarded in the OPTN Kidney Paired Donation Pilot Program's (KPDPP) optimization algorithm as follows: zero mismatch (200 pts), highly sensitized…
  • 2013 American Transplant Congress

    Viral Determinants of Pathogen Induced Alloantibody Production

    R. Ruhil, O. Bulut, S. Talebagha, B. Oh, V. Lu, S. Knechtle, N. Iwakoshi

    Emory Transplant Center, Atlanta

    Background: The appearance of alloantibody can initiate the onset of rapid and destructive antibody-mediated rejection (AMR) or have no demonstrable acute effects. The factors determining…
  • 2013 American Transplant Congress

    CMV Serostatus Correlation with Early Kidney Allograft Transcriptome Change in the GOCAR Cohort

    A. Le Page, W. Zhang, B. Murphy, B. Nankivell, J. Chapman, P. O'Connell, S. Alexander, W. Rawlinson

    University of NSW, Randwick, Australia; Mt Sinai School of Medicine, New York; Westmead Hospital, Westmead, Australia; The Children's Hospital Westmead, Westmead, Australia

    Identifying transcriptional change in renal allografts infected with Cytomegalovirus (CMV) may be important in understanding CMV effects on graft rejection and injury.We examined transcriptional profiles…
  • 2013 American Transplant Congress

    Late Antibody-Mediated Rejection (AMR) after Kidney Transplantation

    M. Martina, F. Oppenheimer, I. Revuelta, J. Campistol Planas, M. Sole, J. Cid, F. Diekmann

    Nephrology, Hospital Clinic, Barcelona, Spain; Hematology, Hospital Clinic, Barcelona, Spain; Pathology, Hospital Clinic, Barcelona, Spain

    INTRODUCTION: Late AMR can develop at any time post kidney transplantation and represents a major challenge.OBJECTIVE: To characterize a series of kidney transplant recipients with…
  • 2013 American Transplant Congress

    Bortezomib Impacts T-Cell Signaling and Regulatory Pathways

    O. Moussa, M. Askar, H. Gebel, S. Flechner, D. Taber, K. Chavin, P. Baliga, T. Srinivas

    Med. Univ South Carolina, Charleston; Cleveland Clinic, Cleveland; Emory University, Atlanta

    Introduction/ Aims: Bortezomib (PS-341), a selective 26S proteasome inhibitor has been used to treat antibody mediated rejection (AMR) among allograft recipients. The efficacy of Bortezomib…
  • 2013 American Transplant Congress

    Outcomes in Lung Transplantation: The RIFLE Classification Optimizes the Predictive Utility of Post-Transplant Acute Kidney Injury as a Determinant of Early and Late Outcomes

    A. Osho, A. Castleberry, L. Snyder, S. Palmer, S. Lin, R. Davis, M. Hartwig

    Department of Surgery, Duke University Medical Center, Durham, NC; Department of Medicine, Duke University Medical Center, Durham, NC

    The purpose of this study is to compare two methods of classifying acute kidney injury (AKI), the Risk, Injury, Failure, Loss, End stage (RIFLE) and…
  • 2013 American Transplant Congress

    Rate and Causality of Thirty-Day Readmissions Following Renal Transplantation

    M. Watson, D. Goldfarb, V. Krishnamurthi, D. Shoskes, J. Rabets

    Glickman Urological & Kidney Institute, Cleveland Clinic, Cleveland, OH

    Introduction: The Affordable Care Act, added to the Social Security Act, established the Hospital Readmission Reduction Program which will penalize hospitals with excessive 30-day readmissions…
  • 2013 American Transplant Congress

    Single Center Experience with Long-Term Prospective BK Monitoring in Renal Transplantation

    J. Trofe-Clark, D. Sawinski, T. Sparkes, S. Goral, M. Bleicher, R. Bloom

    Pharmacy, Hospital of Univ of Pennsylvania, Philadelphia; Renal, Perelman School of Medicine, Univ of Pennsylvania, Philadelphia, PA

    Prospective screening for BK viremia (BKV) in renal transplant recipients (RTR) may allow earlier detection of BKV reactivation and prevent BKV nephropathy (BKVN). However, utility…
  • 2013 American Transplant Congress

    Pivotal Circulating Antibody Panel for Pre-Transplant Prediction of FSGS Recurrence after Kidney Transplantation, A

    M. Sarwal, M. Delville, T. Sigdel, C. Wei, A. Fernoni, G. Burke, M. Naesens, A. Jackson, N. Alachkar, G. Canaud, C. Legendre, J. Reiser, D. Anglicheau

    California Pacific Medical Center, San Francisco; Department of Kidney Transplantation, Necker Hospital, Paris, France; Division of Transplant Surgery, University of Miami School of Medicine, Miami; Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium; The Johns Hopkins Incompatible Kidney Transplant Team, John Hopkins, Baltimore

    Introduction: Recurrence of focal segmental glomerulosclerosis (rFSGS) after kidney transplantation leads to graft loss. The identity of the involved antibodies and specific immunogenic epitopes remains…
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