2013 American Transplant Congress
NAFLD and Dietary Fatty Acid Composition: The Good, the Bad and the Ugly
Medical University of South Carolina, Charleston, SC
Background: Nonalcoholic steatohepatitis (NASH) is predicted to become the primary cause of end-stage liver disease necessitating transplantation. However, recurrence of NASH and fibrosis post-transplantation is…2013 American Transplant Congress
TCMR Is Underdiagnosed in BK Virus Nephropathy: A Tale of 2 Populations
BK virus nephropathy (BKN) after kidney transplantation is often associated with TCMR-like histology, but pathologists are uncertain about whether this is TCMR. We studied the…2013 American Transplant Congress
Early Emergence of De Novo Donor-Specific Antibody Is Associated with High Incidence of Acute Rejection in Kidney Transplant Recipients
University of Michigan, Ann Arbor, MI
Purpose: De novo HLA donor-specific antibodies (dnDSA) is common in chronic renal allograft rejection. However, the significance of dnDSA is less clear in the early…2013 American Transplant Congress
Levels of IL-33 and Soluble IL-33 Receptor (sST2) Distinguish Acute Rejection from Enteritis in Small Bowel Transplant Recipients
BackgroundIL-33 is a member of the IL-1 cytokine family with functions ascribed to its actions on immune cells expressing the IL-33 receptor, ST2. Following heart…2013 American Transplant Congress
New OPTN Requirement for DNA-Based HLA Typing for Deceased Donors: Initial Results Show Increased Typing Resolution for Improving Virtual Crossmatches, A
UCSF, San Francisco, CA; UNOS, Richmond, VA; Cedars-Sinai, Los Angeles, CA
Historically HLA typing of deceased donors was performed using serological or DNA-based methods. On 6/1/11, the Organ Procurement and Transplantation Network (OPTN) implemented a new…2013 American Transplant Congress
IRF-1 Regulates Immune Reactivity in Mouse Hepatic Allografts
Introduction: We have shown previously that Interferon Regulatory factor-1 (IRF-1) contributes to liver I/R injury by activating proinflammatory genes, but its role in host responses…2013 American Transplant Congress
Renal Transplant Recipients (RTR) with Immune Mediated Graft Injury Display Significant Alterations within the Peripheral B Cell Phenotype
St. James's University Hospital, Leeds, United Kingdom; UCL, London, United Kingdom
Phenotypic characterization of PBMCs constitutes part of the immune signature for operational tolerance in RTR. Alterations in the PBMCs of RTR with biopsy proven microcirculation…2013 American Transplant Congress
Application of Rejection Reversal as Defined by Efficacy Endpoints in Present Day Renal Transplantation
The Methodist Hospital, Houston, TX
In the 1990s, the Efficacy Endpoints (EE) studies proposed criteria for 'successful' response to rejection treatment based on serum creatinine (Cr) as a marker of…2013 American Transplant Congress
Impact of Proposed US Public Health Service Guidelines for Increased Risk Organ Donors: A Single OPO Analysis
Background: Currently, the OPTN defines donors at increased risk for disease transmission as those donors who meet exclusionary criteria present in 1994 US PHS Guidelines.…2013 American Transplant Congress
B Cell “Pas De Deux”: TIM-4 Identifies the Proinflammatory B Effector 1 (Be1) Subset, While TIM-1 Identifies Regulatory Be2/Breg Cells
Surgery, University of Pittsburgh, Pittsburgh, PA
B cells perform important immunological functions. Beyond their unique role in humoral immunity, B cells can serve as APCs, provide co-stimulation, and produce cytokines that…
American Transplant Congress abstracts