2013 American Transplant Congress
Decreased Parathyroid Klotho Expression Is Associated with Persistent Hyperparathyroidism after Kidney Transplantation
Background. Although successful kidney transplantation usually corrects hyperparathyroidism, the condition will persist in some patients. The present study was designed to determine whether Klotho or…2013 American Transplant Congress
Progression of Pathologic Changes in Kidney Allografts of HLA-Incompatible Transplant Recipients
We studied the development of kidney graft injury over 1-9 years post-transplant follow up (FU) in 218 patients transplanted with an HLA-incompatible kidney between 2000…2013 American Transplant Congress
Multicenter Evaluation of Influenza Viral Loads in Infected Transplant Recipients
Introduction: Influenza infection is common post-transplant. However, virologic characteristics such as viral load (VL) and duration of shedding have not been well studied in organ…2013 American Transplant Congress
Outcome of Luminex Single Antigen Bead DSA Detection in Post-Transplant Alloantibody Producing Recipients Does Not Correlate with Differential Graft Loss, The
Background: It is unclear whether detection of DSA by Luminex single antigen beads (LumSAg) accurately identifies those post-transplant alloantibody producing recipients at higher risk for…2013 American Transplant Congress
Positive Solid Phase C1q Assays in Patients with Antibody-Mediated Rejection Correlate with the Presence of HLA Antibodies with High MFI Values
Pathology/Lab Medicine and Nephrology, University of Wisconsin-Madison, Madison, WI
Background: The ability of donor specific HLA antibodies (DSA) to fix complement is regarded to be a primary mechanism for antibody-mediated rejection of organ allografts.…2013 American Transplant Congress
Poor Outcome in Non-Sensitized Patients Developing De Novo Circulating Antibodies after Heart Transplantation
Cedars-Sinai Heart Institute, Los Angeles, CA
BACKGROUND: According to the 2012 ISHLT Registry, two-thirds of patients at the time of transplant do not have circulating antibodies. For these non-sensitized patients, the…2013 American Transplant Congress
ATG Induction for Sensitized Patients Who Have Undergone Heart Transplant: Is It Beneficial?
Cedars-Sinai Heart Institute, Los Angeles, CA
BACKGROUND: Heart transplant recipients who are sensitized pre-transplant are at increased risk for the development of antibody mediated and cellular rejection post transplantation. The use…2013 American Transplant Congress
Dichotomous T-Cell Repopulation after Anti-Thymocyte Globulin Induction Therapy in High Immunological Risk and DCD Renal Transplant Recipients
Background:T-cell suppression through induction therapy is routinely used to promote graft survival in high immunological risk (HR) and donation after cardiac death (DCD) renal transplant…2013 American Transplant Congress
Epigenetic Approach for Standardized and Quantitative Analysis of Renal Allograft Biopsies: Acute Cellular Rejection Is Characterized by Infiltration of Th17 and Treg Cells
Outcome and prognosis of kidney transplantation are determined by allograft rejection. Some evidences suggest an involvement of Th17 cells, a cell subset producing IL-17, in…2013 American Transplant Congress
Impact of Delayed Graft Function (DGF) and KDRI on Kidney Graft Survival in HIV (+) Transplant Recipients (HIV KTx)
Transplantation, Drexel University College of Medicine, Philadelphia, PA
Background: Kidney transplant graft survival remains suboptimal in HIV (+) patients. We, and others, have reported an association of both DGF with markedly inferior graft…