2022 American Transplant Congress
Regulatory T Cells Suppress Memory IFN-Gamma Production in Highly Sensitised Patients
*Purpose: Highly sensitized patients (HS) present worse long-term outcome after transplantation compared to those without donor-specific antibodies (DSA). It has been suggested that desensitisation using…2022 American Transplant Congress
Induction of Tolerance After Intestinal Transplantation in a Porcine Model
Columbia Center for Translational Immunology, Columbia University, New York, NY
*Purpose: We describe a case of tolerance from our study investigating multilineage chimerism under immunological conditions after intestinal transplantation using a porcine model with defined…2022 American Transplant Congress
Validation of the iBox Surrogate End Point in CNI Free, Belatacept Treated Patients (BENEFIT & BENEFIT-EXT)
*Purpose: The iBox is a prognostication system for long-term kidney allograft survival, developed with mostly patients under a CNI based immunosuppression. Patients treated with a…2022 American Transplant Congress
Donor-Derived Cell-Free DNA as a Biomarker of T Cell Mediated Rejection in Pediatric Kidney Transplant Patients
*Purpose: T-cell-mediated rejection (TCMR) is a major cause of kidney allograft failure which requires kidney biopsy for a definitive diagnosis. Donor-derived cell-free DNA (dd-cfDNA) is…2022 American Transplant Congress
Heterogeneity in Center Practices in Liver Transplantation for Alcohol-Associated Liver Disease in the United States
*Purpose: Alcohol-associated liver disease (ALD) is now the leading indication for liver transplantation (LT) in the United States (US), particularly since LT has emerged as…2022 American Transplant Congress
Use of Ancestral Genetic SNP Phenotyping to Define Genotypic Ethnicity in Solid Organ Transplant Patients
Surgery, Baylor College of Medicine, Houston, TX
*Purpose: Transplantation research has mainly categorized ethnicity into four main groups African American, Caucasian, Hispanic, and Asian Pacific Islander. Our world has increased in admixure…2022 American Transplant Congress
Proteomic Profiling of Bile from Human Livers Undergoing Viability Assessment via Normothermic Machine Perfusion Prior to Transplantation
*Purpose: Normothermic machine perfusion (NMP) has gained increasing traction as a method to assess the viability of high-risk donor livers. To avoid post-transplant biliary complications,…2022 American Transplant Congress
De Novo Anti-Brush Border Antibody Disease in a Kidney Transplant Recipient
Ohio State University, Columbus, OH
*Purpose: Anti-brush border antibody (ABBA) disease is very rare, characterized by tubulointerstitial damage caused by autoantibodies against LDL receptor-related protein 2 (LRP2) in the proximal…2022 American Transplant Congress
Racial Barriers to Kidney Transplant After Listing, 2015 – 2020
*Purpose: We sought to evaluate racial disparities in access to deceased donor kidney transplant (DDKT) following changes to kidney allocation system (KAS) implemented in 2014.…2022 American Transplant Congress
Using a Unique Repository of Pancreas Transplant Biopsies to Validate the Tissue Common Response Module (tCRM) Score as a Tool to Assess the Severity of Pancreas Transplant Rejection
*Purpose: Analysis of transcriptional data from kidney, heart, liver, and lung transplant rejection led to development of the tissue Common Response Module (tCRM) score based…
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