ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    Effect of Induction Therapy with Thymoglobulin on Outcome in Hepatitis C Infected Kidney Transplant Recipients: A Single Center Experience

    J. Linatoc, Q. Ren, M. Behnke, M. Posner, A. King

    Virginia Commonwealth University, Richmond

    This study evaluated the impact of induction therapy with thymoglobulin (ATG) on outcome in hepatitis C virus positive (HCV+) kidney transplant recipients.We retrospectively studied 79…
  • 2013 American Transplant Congress

    Identification of EBV-Specific CXCR3+/CXCR5+ CD8+T Cells in Peripheral Blood of Asymptomatic Pediatric Heart Transplant Recipients Who Carry EBV Loads

    C. Macedo, T. Shipley, K. Hadi, A. Norlander, J. Luce, B. Feingold, S. Webber, D. Metes

    Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh; Cardiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh; Immunology, University of Pittsburgh, Pittsburgh

    Unlike immunocompetent healthy subjects who carry EBV infection in a latent form, approximately 70% of EBV asymptomatic immunosuppressed pediatric heart transplant (HTx) recipients carry chronic…
  • 2013 American Transplant Congress

    Challenges in Safety Managing the Pain in Living Liver Donors

    D. Ladner, K. Waitzman, T. Strenski, E. Pomfret, M. Simpson, R. Brown, R. Fisher, R. Kang, T. Berzins, A. Daud, J. Holl, D. Woods

    Northwestern University, Chicago; Lahey Clinic, Boston; Columbia University, New York; Virginia Commonwealth University, Richmond

    BACKGROUND: Living Liver Donation (LD) is a highly complex major surgical procedure associated with pain. However, managing pain after LD is difficult, as opioid pharmacokinetics…
  • 2013 American Transplant Congress

    Esophageal Eosinophilia after Intestinal Transplantation

    K. Khan, C. Desai, R. Girlanda, E. Island, C. Matsumoto, T. Fishbein, S. Kaufman

    Transplantation, MedStar Gerogetown University Hospital, Washington, DC

    Background: The prevalence of eosinophilic esophagitis (EoE) has been increasing, with estimates up to 0.1% of children. We examined esophageal eosinophilia in children after intestinal…
  • 2013 American Transplant Congress

    Human Regulatory B Cells (BRegs) Are Characterised by Both IL-10 and TNF-α Expression and Are Reduced in Numbers with Altered Function in Renal Transplant Recipients with Immunological Graft Injury

    A. Cherukuri, A. Salama, C. Carter, B. Clark, D. Rothstein, R. Baker

    St.James's University Hospital, Leeds, United Kingdom; UCL, London, United Kingdom; UPMC, Pittsburgh

    Human Bregs are defined by their ability to express IL-10 and suppress T cells in vitro. We noted that putative Breg subsets also produce pro-inflammatory…
  • 2013 American Transplant Congress

    Anti-CD3 Accelerated Diabetes in Transgenic Non-Obese Diabetic (NOD) Mice Expressing miRNA Decoy Sequence(s)

    O. Pankewycz, J. Xuan, L. Shen, J. Ambrus, Jr, M. Laftavi

    Medicine, SUNY at Buffalo; Surgery, SUNY, University at Buffalo, Buffalo, NY

    Microinhibitory RNAs (miRNAs) are short sequences that regulate post-transcriptional mRNA and protein expression. miRNA decoy genes alter gene expression by interfering with miRNA binding to…
  • 2013 American Transplant Congress

    All-Trans Retinoic Acid Promotes the Development of Inducible Nitric Oxide Synthase Producing Dendritic Cells with T Cell Suppressive Function

    S. Bhatt, J. Qin, L. Wang, S. Qian, T. Hamilton, L. Lu

    Department of Molecular Medicine, The Cleveland Clinic, Cleveland, OH; Department of Immunology, The Cleveland Clinic, Cleveland, OH; Department of General Surgery, The Cleveland Clinic, Cleveland, OH

    Hepatic stellate cells (HSCs) have potent immunoregulatory properties and have been shown to induce myeloid cells with suppressive function, which contribute to liver transplantation tolerance.…
  • 2013 American Transplant Congress

    Systematic Approach Successfully Increases Kidney Transplantation

    K. O'Connor, C. Wells, L. Olson, J. Kisthard

    Organ Donation Services, LifeCenter Northwest OPO, Bellevue, WA

    Purpose: Evaluate the impact of a systematic, disciplined approach to increasing kidney transplantation, including clear goals, measurement system, integration of organ procurement organization (OPO) with…
  • 2013 American Transplant Congress

    Telaprevir Based Combination Therapy for the Treatment of Recurrent HCV in Liver Transplant Recipients: Promising Early Results, Late Disappointment

    B. Gelb, R. Layman, L. Teperman

    Department of Surgery, Division of Transplant Surgery, NYU Langone Medical Center, New York, NY

    Background:HCV recurrence is virtually universal in viremic patients at the time of transplant. Long term patient and graft survival is inferior in HCV patients unless…
  • 2013 American Transplant Congress

    Enhanced Liver Regeneration in Mice Lacking the Chemokine Receptor CCR5

    C. Gonelle-Gispert, S. Sorce, P. Morel, R. Meier, S. Lacotte, D. Bosco, L. Buhler

    Surgical Research Unit, University of Geneva, Medical School, Geneva, Switzerland; Pathology and Immunology, University of Geneva, Medical School, Geneva, Switzerland; Surgical Research Unit, University Hospitals of Geneva, Geneva, Switzerland; Surgical Research Unit, University of Geneva, Medical School, Geneva, Switzerland; Surgical Research Unit, University of Geneva, Medical School, Geneva, Switzerland; Surgical Research Unit, University of Geneva, Medical School, Geneva, Switzerland; Surgical Research Unit, University of Geneva, Medical School, Geneva, Switzerland

    Introduction: Further knowledge of basic mechanisms that regulate liver regeneration may help to find therapies to increase otherwise insufficient liver mass. The chemokine receptor CCR5…
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