ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    Epitope Analysis of col(V)-Specific Th17 Cell Responses in Lung Transplantation Reveals an HLA-DRB1*1501 Bias in Both Patient and Donor

    W. Burlingham, M. Keller, L. Haynes, E. Gan, V. Agashe, G. Leverson

    Surgery, UW Madison, Madison, WI

    Fibro-obliterative disease of the airways and vessels is a key element of the chronic rejection process after heart and lung transplantation. Th17 cellular immune responses…
  • 2013 American Transplant Congress

    Harmonization of an LC-MS/MS Assay for Therapeutic Drug Monitoring of Tacrolimus

    C. Joynes, D. Mason, T. Annesley, E. Champarnaud, C. Mussell, L. Calton, L. Harter, D. McKeown

    Waters Corp., Milford, MA; The University of Michigan, Ann Arbor, MI; LGC Limited, Teddington, United Kingdom; Waters Corp., Manchester, United Kingdom; Analytical Services International Ltd., London, United Kingdom

    Background: Monitoring concentrations of tacrolimus in allograft recipients is considered the standard of care. Trough concentrations are regarded as a good surrogate for tacrolimus exposure.…
  • 2013 American Transplant Congress

    Synergism of Complement-Fixing and Non-Complement-Fixing Antibodies to MHC Class I in Pathogenesis of Obliterative Airway Disease: Obligatory Role for the Fc Portion of Immunoglobulins

    V. Subramanian, M. Takenaka, V. Tiriveedhi, A. Gelman, G. Patterson, T. Mohanakumar

    Washington University, St. Louis, MO

    Background: Our previous results demonstrated that both complement fixing (cfABS) as well as non-complement fixing antibodies (ncAbs) to MHC class I result in obliterative airway…
  • 2013 American Transplant Congress

    Contemporary Analysis of the Effect of Induction Immunosuppression of Survival in Pediatric Lung Transplant Recipients, A

    D. Hayes, Jr., S. Kirkby, A. Wehr, A. Lehman, P. McConnell, M. Galantowicz, R. Higgins, B. Whitson

    Department of Pediatrics, The Ohio State University, Columbus, OH; Department of Internal Medicine, The Ohio State University, Columbus, OH; Center for Biostatistics, The Ohio State University, Columbus, OH; Department of Surgery, The Ohio State University, Columbus, OH

    Introduction:The role of induction immunosuppression in lung transplantation (LTX) is varied. In the pediatric population, due to a smaller national incidence and center practice variability,…
  • 2013 American Transplant Congress

    What Is the Definition of Geographic Equity in Kidney Transplantation?

    A. Davis, S. Mehrotra, L. McElroy, J. Friedewald, D. Ladner

    Northwestern University, Chicago

    Purpose: Since the 1990s, a patient’s likelihood of receiving a kidney transplant has highly depended on where a patient resides around the United States. In…
  • 2013 American Transplant Congress

    Modification of the Cavaplasty (Hug Procedure) Technique in Liver Transplantation

    Y. Wu, L. Mosna, S. Zhang, K. Wolfe

    Westchester Medical Center, Valhalla, NY; First Hospital of Qunming, Qunming, YunNan, China

    Introduction: The Cavaplasty OLT, now called Hug Procedure, offers advantages for hepatectomy and implantation and eliminates outflow obstruction. However, caval clamping is required during the…
  • 2013 American Transplant Congress

    Successful Transplantation of Kidney Allografts in Sensitized Rats Made Possible by Autologous Hematopoietic Stem Cell Transplantation (HSCT) and Fludarabine

    Y. Fu, R. Montgomery, Y. Wang, E. Fuchs, Z. Shen, G. Williams, Z. Sun

    Johns Hopkins University School of Medicine, Baltimore; Tianjin First Central Hospital and Tianjin Medical University, Tianjin, China

    We tested whether resetting the immune system with autologous HSC after preconditioning with Fludarabine improves kidney allograft survival in sensitized hosts.Methods: MHC mismatched DA (RT1Aa)…
  • 2013 American Transplant Congress

    Good Second Kidney Transplant Outcomes in Pediatric Patients with Early First Kidney Graft Loss

    M. Gupta, A. Wood, N. Mitra, S. Furth, P. Abt, M. Levine

    Department of Surgery, Division of Transplantation, University of Pennsylvania, Philadelphia, PA; Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Department of Nephrology, Children's Hospital of Philadelphia, Philadelphia, PA

    Intro:Pediatric kidney transplant (KTx) recipients with early first kidney graft loss(within 30 days) may have graft failure from technical complications or patient disease(hypercoagulability, acute rejection,…
  • 2013 American Transplant Congress

    Prospective Randomized Study of Low Dose Antithymocyte Globulin as Induction in Non Sensitized Adult Renal Transplant Recipients

    M. Grafals, M. Simpson, H. Gilligan, J. Pomposelli, M. Akoad, K. Kwaja, A. Trabucco, K. Hamill, E. Pomfret

    Georgetown Transplant Institute, Georgetown University Hospital, Washington, DC; Transplant Surgery, Lahey Clinic Medical Center, Burlington, MA

    Induction agents are commonly utilized in the United States to prevent acute rejection in renal transplant recipients. The most common induction agent used is rabbit…
  • 2013 American Transplant Congress

    Anti-Angiotensin Type 1 Receptor Antibodies Associated with Rejection in Donor HLA Antibody Negative Recipients

    N. Reinsmoen, C. Lai, J. Mirocha, K. Cao, M. Naim, G. Ong, Q. Wang, H. Duong, S. Riega, M. Rafiei, J. Patel, J. Kobashigawa

    Cedars-Sinai Medical Center, Los Angeles, CA

    Anti angiotensin type 1 receptor (AT1R) antibodies have been found associated with rejection in renal recipients (recips) in the absence of donor HLA specific antibodies…
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