ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    High Frequency of Valganciclovir Under- and Overdosing for CMV Prophylaxis after Renal Transplantation

    O. Rissling, M. Naik, S. Brakemeier, A. Hohberger, H. Neumayer, K. Budde

    Department of Nephrology, Charite-Universitätsmedizin Berlin CCM, Berlin, Germany

    The correct valganciclovir (vgc) dose for CMV-prophylaxis depends on renal function as assessed by the Cockroft Gault formula (CG-eGFR) for patients (pts) after transplantation (Tx).We…
  • 2013 American Transplant Congress

    Donor HSCs from the Bone Component of Vascularized Composite Allografts Migrate to Recipient Thymus and Differentiate to Mature T Cells

    R. Sucher, C. Lin, D. Zhang, W. Zhang, J. Grahammer, J. Pratschke, W. Lee, S. Schneeberger, X. Zheng, G. Brandacher

    Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Insbruck, Austria; Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore; Starzl Transplant Institute, UPMC, Pittsburgh

    Introduction:Vascularized composite allografts (VCA) feature an inexhaustible source of donor HSCs, which under proper immunomodulation might be able to migrate into the recipient’s thymus and…
  • 2013 American Transplant Congress

    Post-Transplant Complement Binding DSA: Higher Risk of Kidney Allograft Loss

    C. Lefaucheur, A. Loupy, D. Vernerey, C. Suberbielle, X. Jouven, C. Legendre, D. Glotz, A. Zeevi

    Kidney Transplantation, Saint-Louis Hospital, Paris, France; Kidney Transplantation, Necker Hospital, Paris, France; Paris Cardiovascular Research Centre, INSERM, UMR-S970, Paris, France; Histocompatibility, Saint-Louis, Paris, France; University of Pittsburgh, Pittsburgh, PA

    Anti-HLA antibodies are a major obstacle to transplantation success. We hypothesized that the complement binding capacity of anti-HLA antibodies assessed in the recipient sera could…
  • 2013 American Transplant Congress

    Killer Immunoglobulin-Like Receptor (KIR) Mismatches and KIR-HLA-C Interactions Do Not Affect Short Term Graft Function in Kidney Transplantation

    E. Eksioglu-Demiralp, M. Elbasi, F. Ture-Ozdemir, A. Tulunay, I. Tatli-Aydin, A. Turkmen, B. Kocak

    Tissue Typing and Immunology, Istanbul Memorial Hospital, Transplantation Unit, Istanbul, Turkey; Basic Immunology, Marmara University, School of Medicine, Istanbul, Turkey; Transplantation Unit, Istanbul Memorial Hospital, Istanbul, Turkey

    Human Leucocyte Antigen (HLA) matching is an important factor in long term graft survival in kidney transplantations. Natural Killer (NK) cells with their MHC recognizing…
  • 2013 American Transplant Congress

    Normothermic Acellular Ex Vivo Liver Perfusion (NEVLP): Development of a New Method for the Storage, Assessment, and Repair of Marginal Liver Grafts

    M. Boehnert, J. Knaak, O. Adeyi, P. Yip, N. Selzner, G. Levy, S. Keshavjee, D. Grant, M. Selzner

    Department of Surgery, Multi Organ Transplant Program, Toronto General Hospital, Toronto, ON, Canada; Department of Pathology, Toronto General Hospital, Toronto, ON, Canada; Department of Clinical Chemistry, Toronto General Hospital, Toronto, ON, Canada; Department of Surgery, Toronto Lung Transplant Program, Toronto General Hospital, Toronto, ON, Canada

    We compared the novel normothermic acellular ex vivo liver perfusion (NEVLP) with conventional cold static organ preservation for livers retrieved after cardiac death.Methods: Pig livers…
  • 2013 American Transplant Congress

    Optimizing Kidney Exchange with Transplant Chains: Theory and Reality

    J. Dickerson, A. Procaccia, T. Sandholm

    Computer Science Department, Carnegie Mellon University, Pittsburgh, PA

    We explore the theoretical and empirical efficacy of long altruist-initiated chains in kidney exchange programs. Kidney exchange, where needy patients swap incompatible donors with each…
  • 2013 American Transplant Congress

    Pattern of Utilization and Graft Outcomes of Patients Received Kidney Transplants from Deceased Donors < 4 Years, The

    T. Jie, M. Porubsky, A. Rana, B. Kaplan, R. Gruessner, A. Gruessner

    Department of Surgery, University of Arizona, Tucson, AZ; Department of Medicine, University of Arizona, Tucson, AZ

    Kidneys from donors < 4 years remain underutilized because of the concerns of the recipient complications (bleeding, urine leak and graft thrombosis), and poor long-term…
  • 2013 American Transplant Congress

    Comparison of Protein A-Immuno-Adsorption and Conventional Plasma Exchanges for Anti-HLA Desensitization

    N. Maillard, I. Masson, M. Mehdi, E. Alamartine, C. Mariat

    Nephrology, Dialysis, Transplantation, University Hospital, Saint-Etienne, France

    Plasma exchanges therapy is traditionally part of anti-HLA desensitization strategies used in kidney transplantation. As compared to conventional techniques of plasma exchanges (PE) (plasma-centrifugation or…
  • 2013 American Transplant Congress

    “Spontaneous” Reduction in Donor Specific Allo-Antibody (DSA) after Positive Cross Match Kidney Transplantation (+XMKTx) Is Associated with Improved Histology

    S. Raghavaiah, M. Gandhi, L. Cornell, W. Kremers, P. Dean, T. Taner, M. Stegall

    Transplant, Mayo Clinic, Rochester, MN; Transfusion Medicine, Mayo Clinic, Rochester, MN; Anatomic Pathology, Mayo Clinic, Rochester, MN

    Introduction.In a recent study (AJT,2011;11:2405), eculizumab decreased the incidence of early antibody mediated rejection(AMR) after +XMKTx. Post-transplant plasma exchange (PE) was not routinely used thus…
  • 2013 American Transplant Congress

    Effect of the Purinergic Inhibitor Oxidized-ATP in a Model of Islet Allograft Rejection

    A. Vergani, R. Bassi, F. D'Addio, C. Fotino, S. Tezza, R. Molano, A. Soleti, P. Maffi, A. Secchi, C. Ricordi, M. Sayegh, A. Pileggi, P. Fiorina

    Boston Children's Hospital/Harvard Medical School, Boston; San Raffaele Scientific Institute, Milan, Italy; DRI, University of Miami, Miami; Medestea, Torino, Italy

    The lymphocytic ionotropic purinergic P2X receptors (P2X1R-P2X7R, or P2Xs) sense the ATP, released during cell damage-activation, thus regulating T-cell activation. We aim to define the…
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