Abstracts Archive - Page 159 of 1683 - ATC Abstracts

2022 American Transplant Congress
The Role of T Lymphocyte Subsets in Kidney Transplantation
L. Vagiotas¹, A. Xochelli², E. Sampani³, V. Nikolaidou², D. Asouchidou², E. Kasimatis³, N. Antoniadis¹, M. Daoudaki⁴, M. Stangou³, A. Papagianni³, G. Tsoulfas¹, A. Fylaktou²
¹Division of Organ Transplantation, Department of Surgery, Aristotle University Medical School, Hippokration Hospital, Thessaloniki, Greece, ²National Peripheral Histocompatibility Center, Immunology Department, Hippokration Hospital, Thessaloniki, Greece, ³Department of Nephrology, Aristotle University Medical School, Hippokration Hospital, Thessaloniki, Greece, ⁴Laboratory of Biological Chemistry, Faculty of Medicine Aristotle University of Thessaloniki, Thessaloniki, Greece
*Purpose: Impairment of cellular immune function in kidney transplant candidates is not concomitantly restored with the recovery of renal function, as alloimmune response and implementation…
2022 American Transplant Congress
Liver Outcomes and Equity (LOEq) Index: Neighborhood-Level Social Determinants of Health and Waitlist Disparities for Adult Liver Transplantation
K. Zhou, L. S. Kuo, L. K. Thompson, J. L. Dodge, M. G. Cockburn, N. Terrault
University of Southern California, Los Angeles, CA
*Purpose: Impact of neighborhood-level social determinants of health (SDOH) among adult liver transplant (LT) candidates is largely unknown. We constructed a novel index (LOEq) to…
2022 American Transplant Congress
Effectiveness of a Targeted Media Campaign on Engagement and Interest in Living Donation
L. A. Davis¹, A. Livingston², A. Waterman³
¹Houston Methodist Hospital, J.C. Walter Jr Transplant Center, Houston, TX, ²Multiview, Irving, TX, ³Transplant Research and Education Center, Houston, TX
*Purpose: Living donation rates have continued to decline. Research has suggested that disseminating living donation education and information more broadly to larger audiences outside of…
2022 American Transplant Congress
Characterization Of Gzmb+ Bregs Using Single Cell Rnaseq
N. Sailliet, H. Le Mai, A. Dupuy, C. Fourgeux, M. Chesneau, J. Poschmann, R. Danger, S. Brouard
CRT2I INSERM UMR1064, Nantes, France
*Purpose: Granzyme B (GZMB)+ B cells are increased in blood from transplanted patients who tolerate a kidney graft without immunosuppressive treatment. We demonstrated that these…
2022 American Transplant Congress
Influence of Regulatory B Cells on B Cells
Q. Fu¹, K. M. Lee², K. Deng², D. Agarwal¹, R. Matheson³, T. Press¹, J. Lei⁴, H. Yang⁵, C. LeGuern², S. Deng⁵, J. F. Markmann²
¹Center for Transplant Science, MGH, Boston, MA, ²Massachusetts General Hospital, Boston, MA, ³Transplantation Surgery Research, Massachusetts General Hospital, Boston, MA, ⁴Surgery, Mass General, Boston, MA, ⁵Sichuan Provincial People's Hospital, University of Electronic Sciences and Technology of China, Chengdu, China
*Purpose: Our previous study showed that Bregs-TLR, one type of previously studied Breg expanded in vitro, are capable of suppressing naïve B cell proliferation in…
2022 American Transplant Congress
The Role of the Gut Microbiota in Pain Interference Before and After Kidney Transplantation: A Pilot Study
M. B. Lockwood¹, H. DeVon², M. Maienschein-Cline¹, G. Chlipala¹, M. Samra³, A. Lichvar⁴, S. Green⁵
¹University of Illinois at Chicago, Chicago, IL, ²UCLA, Los Angeles, CA, ³Loyola University Medical Center, Chicago, IL, ⁴UCSD, San Diego, CA, ⁵Rush University, Chicago, IL
*Purpose: To characterize relationships between differential relative abundances of taxonomy (genus level) of the gut microbiome and pain interference before and after living donor kidney…
2022 American Transplant Congress
Effect of CD8+ Cell Depletion in Treg Mediated Skin Graft Survival
R. Steiner¹, A. M. Weijler¹, M. Muckenhuber², J. Sprent³, T. Wekerle⁴, N. Pilat¹
¹Medical University of Vienna, Vienna, Austria, ²Dept. of General Surgery, Div. of Transplantation, Medical University of Vienna, Vienna, Austria, ³Garvan Institute of Medical Research, Sydney, Australia, ⁴Vienna Gen Hosp / Medical Univ of Vienna, A-1090 Vienna, Austria
*Purpose: The selective in vivo expansion and activation of regulatory T cells via administration of interleukin-2 (IL-2) coupled to a specific antibody against IL-2 (IL-2…
2022 American Transplant Congress
Alloimmune Recognition Blocks Recipient Macrophage Differentiation into Reparative Subsets
J. Warunek¹, A. Lucas², L. R. Mathews², M. Oberbarnscheidt², F. Lakkis², H. Turnquist²
¹Immunology, Thomas E. Starzl Transplantation Institute, University at Pittsburgh, Pittsburgh, PA, ²Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: Monocytes differentiate into macrophage subsets that orchestrate tissue repair in response to damage signals and local cytokines. After heart transplant (Tx), graft IL-33 acts…
2022 American Transplant Congress
dd-cfDNA Varies Among Diagnostics Groups of Pulmonary AMR
D. Levine¹, C. Giner¹, C. Pham², R. Woodward³, A. Roux⁴
¹University of Texas Health System San Antonio, San Antonio, TX, ²CareDX, South San Francisco, CA, ³CareDx, South San Francisco, CA, ⁴Pneumology, Adult CF Center and Lung Transplantation Department, Foch Hospital, Suresnes, France
*Purpose: Antibody mediated rejection (AMR) in lung transplant remains complex, with differential diagnosis often overlapping with other causes of lung dysfunction. Diagnostic certainty declines to…
2022 American Transplant Congress
A Signature of Tolerance Which Identifies Subclinical Rejection-Free Patients at One Year After Kidney Transplantation
R. Danger¹, L. Le Berre¹, M. Cadoux¹, C. Kerleau¹, P. Guérif¹, E. Morelon², O. Thaunat², C. Legendre³, D. Anglicheau³, K. Renaudin¹, M. Giral¹, S. Brouard¹
¹Centre de Recherche en Transplantation et Immunologie (CRTI), UMR 1064, ITUN, Nantes Université, CHU Nantes, Inserm, Nantes, France, ²Edouard Herriot Hospital, Hospices Civils de Lyon, Inserm U1111, Lyon-Est Medical Faculty, Claude Bernard University (Lyon 1), Lyon, France, ³APHP, Necker-Enfants Malades Institute, Inserm, Paris University, Paris, France
*Purpose: Spontaneous and rare cases of patients undergoing a functional renal transplant in the absence of immunosuppression represent a particular situation of immune tolerance. We…