ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    Antibody-Mediated Injury Is the Major Cause of Late Kidney Allograft Failure

    R. Gaston, R. Leduc, F. Cosio, S. Gourishankar, J. Grande, L. Hunsicker, B. Kasiske, R. Mannon, A. Matas, D. Rush, M. Cecka

    UAB, Birmingham; U Minnesota, Minneapolis; Mayo Clinic, Rochester; U Alberta, Edmonton, Canada; U Iowa, Iowa City; Hennepin County Med Ctr, Minneapolis; U Manitoba, Winnipeg, Canada; UCLA Immunogenetics Laboratory, Los Angeles

    DeKAF is NIH-funded multicenter observational study of late kidney graft failure with over 4500 recs enrolled from 2006-10. The Cross-Sectional cohort (CS, N=559) includes recs…
  • 2013 American Transplant Congress

    Kidney Intragraft DSA as Determinant of Antibody-Mediated Lesions and Poor Graft Outcome

    T. Bachelet, L. Couzi, S. Lepreux, M. Legeret, G. Pariscoat, G. Guidicelli, P. Merville, J. Taupin

    CHU Bordeaux, Bordeaux, Gironde, France; CNRS. UMR 5164, Bordeaux, Gironde, France; Université Bordeaux Segalen, Bordeaux, Gironde, France

    Allograft pathology, antibody-tissue interaction as demonstrated by C4d deposition, and serologic evidence of donor-specific antibodies (DSA) are the cardinal diagnostic features of antibody-mediated lesions (AML)…
  • 2013 American Transplant Congress

    Interactive Web-Based Patient Portal for the Evaluation of Potential Kidney Transplant Recipients

    A. Webber, S. Tomlanovich, M. Parente, J. Roberts, R. Hirose

    Kidney Transplant Service, UCSF, San Francisco, CA

    Introduction: UCSF implemented newly available information technology to increase access to patients, improve communication, and expedite patient work-up. Using a validated(1-2) web-based software platform (BREEZE…
  • 2013 American Transplant Congress

    RBC Transfusions Are Associated with HLA Allosensitization in Patients Awaiting Kidney Transplantation

    B. Bradbury, M. Leffell, D. Kim, J. Petersen, J. Hart, J. Rossert, R. Vega, A. Zachary

    JHU Immunogenetics Laboratory, Johns Hopkins Uninversity School of Medicine, Baltimore, MD; Amgen, Thousand Oaks, CA

    Introduction: HLA sensitization remains a major barrier to successful kidney transplantation resulting in prolonged wait times, lower transplant rates, and decreased graft survival. This study…
  • 2013 American Transplant Congress

    Long Term Survival of PEGylated Murine Allogenic Islets Using Short Course Immunomodulation

    J. Giraldo, C. Fotino, H. Rengifo, R. Molano, C. Ricordi, A. Pileggi, C. Stabler

    Biomedical Engineering, University of Miami, Miami, FL; Diabetes Research Institute, University of Miami, Miami, FL

    Islet transplantation is a promising therapy for Type 1 diabetes; however, inflammatory and immune host responses lead to islet dysfunction and destruction. Cell surface PEGylation…
  • 2013 American Transplant Congress

    Effects of Human Alpha-1-Antitrypsin (hAAT) Therapy in a Murine Model of Bilateral Kidney Ischemia-Reperfusion Injury

    L. Hilbrands, N. Maicas, J. van der Vlag, M. Bakker, M. Roos, C. Dinarello, L. Joosten

    Nephrology, Radboud University Medical Center, Nijmegen, Netherlands; Medicine, University of Colorado, Denver; Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen, Netherlands; General Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands

    AIM: Several lines of evidence have demonstrated the anti-inflammatory and cytoprotective effects of alpha-1-Antitrypsin (AAT), the major serum serine-protease inhibitor. The aim of the present…
  • 2013 American Transplant Congress

    Factors Associated with Renal Dysfunction at 12 Months Following Liver Transplantation

    W. Irish, M. Tran, C. Escrig, J. Ricci

    CTI Clinical Trial and Consulting Svcs, Raleigh, NC; Novartis Pharmaceuticals Corporation, East Hanover, NJ; Novartis Pharma AG, Basel, Switzerland; Wellman AG, Basel, Switzerland

    Introduction: Renal dysfunction (RD) before and after liver transplantation (LTx) is a significant predictor of graft failure (GF). We investigated the association of donor and…
  • 2013 American Transplant Congress

    Use of Software Imaging To Detect Sarcopenia in Lung Transplant Candidates

    S. Reppert, M. Jensen, P. Eiken, C. Kennedy

    Department of Internal Medicine, Mayo Clinic, Rochester, MN; Division of Endocrinology and Metabolic Diseases, Mayo Clinic, Rochester, MN; Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN; Department of Radiology, Mayo Clinic, Rochester, MN

    Background:Abnormal body mass index (BMI) (both <19 and >30 kg/m2) has been associated with worse outcomes in lung transplantation. However, this measurement cannot assess risks…
  • 2013 American Transplant Congress

    Normothermic In Vivo Graft Perfusion Decreases the Risk of Hepatocellular Carcinoma Recurrence in a Donation-after-Cardiac-Death (DCD) Rat Liver Transplantation Model

    G. Oldani, L. Crowe, S. Lacotte, F. Slits, L. Orci, L. Rubbia-Brandt, P. Morel, G. Mentha, T. Berney, J. Vallée, C. Toso

    Visceral and Transplant Surgery, Geneva University Hospitals (HUG), Geneva, Switzerland; Cell Transplantation Lab, University of Geneva, Geneva, Switzerland; Radiology, Geneva University Hospitals (HUG), Geneva, Switzerland; Clinical Pathology, Geneva University Hospitals (HUG), Geneva, Switzerland

    Background: Liver transplantation from DCD donors is associated to ischemia/reperfusion (IR) lesions, which may increase the risk of post-transplant hepatocellular carcinoma (HCC) recurrence. Normothermic graft…
  • 2013 American Transplant Congress

    Fatigue as Reported at 12 Time Points during the First Year Post-Liver Transplant

    P. Scott, A. Krause, A. Tector, P. Kwo

    Occupational Therapy, Indiana University, Indianapolis, IN; Gasteroenterology, Indiana University, Indianapolis, IN; Surgery, Indiana University, Indianapolis, IN

    BACKGROUND: Although liver transplantation has evolved as an effective procedure, fatigue remains a post-transplant complaint [1]. As yet, there are no published accounts of the…
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