2013 American Transplant Congress
Therapy with mTOR Inhibitors in Polyomavirus Nephropathy: A Five Year Follow Up
Background: Polyomavirus nephropathy (PVAN) has a negative impact on renal allograft survival, and its treatment remains controversial. Therapy options include reduction of immunosuppressive drugs and…2013 American Transplant Congress
In Situ Quantification of 1,3-Galactosyl Transferase Knockout Swine Liver Protein Production Using Quantitative Comparative ELISA
Department of Surgery, MGH, Boston, MA; Transplant Biology Research Center, MGH, Charlestown, MA
Background: Inception of GalT knock out (GalT-KO) miniature swine has helped to ameliorate rapid xenograft rejection, now allowing for investigations into the utility of miniature…2013 American Transplant Congress
Pharmacodynamic and Immunomodulatory Effects of TOL-101: An IgM Anti-αβ TCR Monoclonal Antibody Used for Induction Therapy in Kidney Transplantation, The
Purpose: TOL-101 is a novel IgM monoclonal antibody that specifically targets the ΑΒ TCR. Results from a Phase 2 dose finding efficacy study in 28…2013 American Transplant Congress
Inhibition of Receptor Interacting Protein 3 (RIP3) Promotes Long Term Renal Allograft Survival
Death of kidney parenchymal cells during transplantation occurs through counterbalanced mechanisms of cellular death, apoptosis and necrosis. Members of the receptor interacting protein family (RIP1,…2013 American Transplant Congress
Dose Escalating Anti-αβ-TCR (TOL101) Monoclonal Therapy, Induces Robust Naive and Memory T Inhibition Whilst Promoting Post Dosing Regulatory T Cell Induction
Purpose: Induction therapy success hinges on the ability to robustly inhibit alloreactive T cells. The purpose of this study was to further examine the impact…2013 American Transplant Congress
Trends in Kidney Transplant Outcomes in Older Adults
Johns Hopkins University School of Medicine, Baltimore, MD
BACKGROUND: Recent evidence suggests that, in general, kidney transplant (KT) outcomes are improving over time. However, this evidence is population-based, failing to evaluate trends in…2013 American Transplant Congress
Platelets as Mediator of Alloantibody-Induced Responses in Vascularized Organ Transplantation
Immunology, Lerner Research Institute, Cleveland, OH
Recent research has begun to elucidate the immune function of platelets. A few clinical studies have reported platelet accumulation in renal transplants during acute rejection.…2013 American Transplant Congress
Differentiation of HCV Activation, Severity, and Acute Rejection Using Expression Profiles of Inflammatory Protein and miRNA in the Serum
The aim of this exploratory study was to determine whether inflammatory proteins and/or miRNA in serum specimens collected near the time of protocol or for…2013 American Transplant Congress
Twice Daily Telaprevir in Combination with Peginterferon Alfa-2a/Ribavirin in HCV Genotype 1 Liver Transplant Recipients: Interim Safety/Efficacy of the REFRESH Study
Background: REFRESH is a 2-part Phase 2b, open-label clinical study assessing safety, efficacy, and pharmacokinetics (PK) of telaprevir (T) in combination with peginterferon alfa-2a (P)…2013 American Transplant Congress
Antibody-Mediated Rejection (AMR) in Kidney Transplantation: The Role of Anti-Peroxisomal trans-2-enoyl-CoA Reductase (PECR) Auto-Antibody
Introduction: Peroxisomal trans-2-enoyl-CoA reductase (PECR), a cell component of the mitochondria and peroxisomal membrane, is an enzyme involved in the lipid metabolism and fatty acid…
American Transplant Congress abstracts