ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    Aggravation of Post-Ischemic Liver Injury by Overexpression of IGFBP-3

    J. Yang, H. Yu, B. Park, H. Hwang, B. Cho

    Surgery, Chonbuk National University Medical School and Hospital, Jeonju, Republic of Korea; Biochemistry, Chonbuk National University Medical School, Jeonju, Republic of Korea

    Insulin-like growth factor binding protein-3 (IGFBP-3) is known to interfere NF-ΚB signaling pathway in response to a diverse range of stimuli. Liver ischemia/reperfusion injury is…
  • 2013 American Transplant Congress

    TNF-alpha -238 G-Allele Predisposes to Severe Bacterial Infection in Patients with End-Stage Liver Disease Enlisted for Liver Transplantation, The

    E. de Mare-Bredemeijer, R. Bartáková, S. Franková, D. Roelen, T. Visseren, P. Trunecka, J. Spicák, H. Metselaar, M. Jirsa, J. Kwekkeboom, J. Sperl

    Hepatogastroenterology, Clinical and Experimental Medicine, Prague, Czech Republic; Laboratory of Experimental Medicine, Clinical and Experimental Medicine, Prague, Czech Republic; Hepatogastroenterology, University Medical Center, Rotterdam, Netherlands; Immunohematology and Blood Transfusion, University Medical Center, Leiden, Netherlands

    Background: Augmented susceptibility to infections increases mortality in patients with end-stage liver disease (ESLD). Activation of pro-inflammatory cytokine production via TLR4, which is a major…
  • 2013 American Transplant Congress

    Impact of Sarcopenia on Survival in Patients Undergoing Living Donor Liver Transplantation

    T. Kaido, K. Ogawa, Y. Fujimoto, T. Ito, K. Tomiyama, A. Mori, Y. Ogura, S. Uemoto

    Hepato-Biliary-Pancreatic and Transplant Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Transplant Surgery, Graduate School of Medicine, Nagoya University, Nagoya, Japan

    Background: Skeletal muscle depletion, referred to as sarcopenia, predicts morbidity and mortality in patients undergoing digestive surgery. However, the impact on liver transplantation is unclear.…
  • 2013 American Transplant Congress

    Toll-Like Receptor 4 Blockade Enhances Islet Engraftment and Induces Indefinite Islet Allograft Survival

    T. Berney, L. Giovannoni, V. Lavallard, Y. Muller, S. Lacotte, P. Morel, C. Toso, L. Shang, B. Daubeuf, M. Kosco-Vilbois, D. Bosco

    Department of Surgery, University Hospitals of Geneva, Geneva, Switzerland; NovImmune, Geneva, Switzerland

    The aim of the present study was to assess the role of Toll-like-receptor 4 (TLR4) in mediating the immune response to allogeneic pancreatic islets.We first…
  • 2013 American Transplant Congress

    Tacrolimus Predose Concentrations Do Not Predict the Risk of Acute Rejection after Renal Transplantation: A Pooled Analysis from Three Randomised-Controlled Clinical Trials

    R. Bouamar, N. Shuker, D. Hesselink, W. Weimar, H. Ekberg, B. Kaplan, C. Bernasconi, T. van Gelder

    Hospital Pharmacy, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Internal Medicine, Renal Transplant Unit, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Nephrology and Transplantation, Skane University Hospital, Malmo, Sweden; Medicine, Dept. of Surgery and Pharmacology, University of Arizona School of Medicine, Tucson, AZ; Limites Medical Research Ltd., Vacallo, Switzerland

    Introduction:Therapeutic drug monitoring for tacrolimus (Tac) is universally applied. However, the concentration-effect relationship for Tac is poorly defined. This study investigated whether Tac concentrations are…
  • 2013 American Transplant Congress

    Glomerular Size on Time Zero Kidney Allograft Biopsies and the Change in Kidney Function after Live Kidney Donation

    H. Yan, E. Hendren, J. Dong, T. Hung, M. Mengel, J. Gill

    Division of Nephrology, University of British Columbia, Vancouver, BC, Canada; Department of Pathology, University of British Columbia, Vancouver, BC, Canada; Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB, Canada

    Identification of predictors of the decrease in kidney function after live kidney donation may help expand the living donor pool or identify donors for long-term…
  • 2013 American Transplant Congress

    Impact of Graft Implantation Order on Short- and Long-Term Graft Survival in Simultaneous Pancreas-Kidney Transplants, The

    N. Niclauss, B. Bédat, A. Andres, C. Toso, P. Morel, T. Berney

    Department of Visceral Surgery and Transplantation, Geneva University Hospitals, Geneva, Switzerland

    IntroductionThe preferred order of revascularization of pancreas and kidney grafts in simultaneous pancreas-kidney transplants has not yet been established. Increased preservation time might have a…
  • 2013 American Transplant Congress

    Restored Kidney Transplant after Resection of Small Renal Tumor into Unrelated and Related Recipients: Updated Results of Clinical Trials

    Y. Ogawa, T. Kobayashi, S. Shiroma, K. Kojima, R. Mannami, M. Mannami, K. Kitajima, M. Nishi, M. Tamaki, H. Afuso, S. Ito, N. Mituhata

    Urology, Tokyo-West Tokushukai Hospital, Akishima, Tokyo-to, Japan; Urology, Uwajima Tokushukai Hospital, Uwajima, Ehime-ken, Japan; Urology, Kagoshima Tokushukai Hospital, Kagoshima, Kagoshima-ken, Japan; Urology, St Martin Hospital, Sakaide, Kagawa-ken, Japan; Urology, Okinawa Chubu Tokushukai, Okinawa, Okinawa-ken, Japan; Urology, Kure Kyosai Hospital, Kure, Hiroshima-ken, Japan

    OBJECTIVES: Kidneys after nephrectomy for small renal tumor have been considered as a potential source for solving the organ donor shortage. Buell, Mannami, Nicol, Meng,…
  • 2013 American Transplant Congress

    Outcomes of Full-Right-Full Left Split Liver Transplantation in Adults

    R. Saidi, B. Movahedi, N. Jabbour, Y. Li, A. Bozorgzadeh

    University of Massachusetts, Worcester

    Introduction: Full-right-full-left split liver transplantation (FRFLSLT) has been proposed as an option to overcome organ shortage in adults.Method: This study assessed the outcome of FRFLSLT…
  • 2013 American Transplant Congress

    Effect of Human Adipose Derive Mesenchymal Stem Cells on Acute Liver Failure Model in Murine, The

    R. Saidi, B. Rajeshkumar, O. Walter, A. Shariftabrizi, K. Dresser, B. Movahedi, N. Jabbour, A. Bozorgzadeh

    University of Massachusetts, Worcester

    Acute liver failure (ALF) still carries a high mortality. The incidence of ALF is approximately 2000 cases annually. Drug-related hepatotoxicity accounts for more than 50%…
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