Abstracts Archive - Page 154 of 1683 - ATC Abstracts

2022 American Transplant Congress
Engineered IL-2 Plus Calcineurin Inhibitor Synergistically Expands Regulatory T Cells Transduced with Engineered IL-2 Receptor and Facilitates Establishment of Transplantation Tolerance
T. Hirai¹, P. Lin², T. L Ramos², K. Garcia³, R. S Negrin²
¹Urology, Tokyo Women's Medical University, Tokyo, Japan, ²Blood and Marrow Transplantation, Stanford University, Stanford, CA, ³Molecular and Cellular Physiology and Structural Biology, Stanford University, Stanford, CA
*Purpose: Clinical trials for regulatory T cell (Treg) therapy in organ transplant has shown promising results. However, it is still under the debate which drugs…
2022 American Transplant Congress
Dynamic Changes in Titer and Specificity Autoantibodies in Chronic Bm12 to B/6 Kidney Rejection
I. Sayin¹, D. Yin¹, D. Ghosh², M. Clark², A. Chong¹
¹Department of Surgery, University of Chicago, Chicago, IL, ²Department of Medicine, University of Chicago, Chicago, IL
*Purpose: Loss of autoreactive B cell tolerance and production of non-HLA autoantibodies have been observed in patients undergoing chronic rejection, however, how autoreactive B cells…
2022 American Transplant Congress
Association Between Maintenance Immunosuppressive Regimens And Covid-19 Mortality In Kidney Transplant Recipients
A. O. Gérard¹, S. Barbosa², D. Anglicheau³, L. Couzi⁴, M. Hazzan⁵, O. Thaunat⁶, G. Blancho⁷, S. Caillard⁸, A. Sicard¹
¹Nephrology, Nice University Hospital, Nice, France, ²Institute of Molecular and Cellular Pharmacology, CNRS, Valbonne, France, ³Nephrology, Necker University Hospital, APHP, Paris, France, ⁴Nephrology, Bordeaux Pellegrin University Hospital, Bordeaux, France, ⁵Nephrology, Lille University Hospital, Lille, France, ⁶Nephrology, Edouard Herriot Hospital, Hospices civils de Lyon, Lyon, France, ⁷Nephrology, Nantes University Hospital, Nantes, France, ⁸Nephrology, Strasbourg University Hospital, Strasbourg, France
*Purpose: Kidney transplant recipients (KTR) are at increased risk of mortality from COVID-19. We conducted a cohort study among KTR from the French Solid Organ…
2022 American Transplant Congress
Non-Invasive Assessment of Hepatic Ischemia-Reperfusion Injury Using Dynamic Contrast Enhanced-MRI and T2 Mapping
O. C. Rodriguez¹, J. R. Liggett², J. Kang², K. Loh², Y. Lee¹, N. Sang¹, B. He¹, Y. Cui², K. Oza², D. Kwon³, B. Kallakury³, T. Fishbein², W. Cui², K. Khan², C. Albanese¹, A. Kroemer²
¹Lombardi Comprehensive Cancer Center and the Center for Translational Imaging, Georgetown University Medical Center, Washington, DC, ²MedStar Georgetown Transplant Institute, Washington, DC, ³Pathology, MedStar Georgetown University Hospital, Washington, DC
*Purpose: Hepatic ischemia-reperfusion injury (IRI) is a consequence of liver transplantation and hepatectomy that varies in severity and clinical significance. The diagnosis is made based…
2022 American Transplant Congress
Increased Plasminogen Activator Inhibitor-1 is Associated with Less Severe Clinical Bleeding After Reperfusion During Liver Transplantation
H. J. Braun, N. Ascher, G. Roll, J. Roberts, C. Niemann, M. Bokoch
University of California, San Francisco, San Francisco, CA
*Purpose: Severe bleeding following reperfusion in liver transplantation (LT) is often discrepant with available objective laboratory and thromboelastography data. This bleeding may be due to…
2022 American Transplant Congress
National Trends in Medicare Surgeon Fee Reimbursement for Abdominal Transplant Procedures Over Two Decades
T. C. Hydrick¹, B. Ruch², J. Wagler², J. Harbell², W. Hewitt², C. Jadlowiec², N. Katariya², A. Moss², M. Nguyen², K. S. Reddy², A. Singer², A. K. Mathur²
¹Mayo Clinic Alix School of Medicine, Phoenix, AZ, ²Mayo Clinic, Phoenix, AZ
*Purpose: Reimbursement for surgical procedures has been declining across surgical disciplines. CMS is one of the largest payers for abdominal transplant services, and changes in…
2022 American Transplant Congress
Monitoring Efficacy of Tocilizumab Treatment for Chronic Antibody Mediated Rejection (cAMR) in Kidney Transplants Using Donor-Derived Cell-Free DNA (dd-cf-DNA)
J. Tang¹, A. Vo¹, E. Huang¹, X. Zhang², N. Ammerman¹, A. Peng¹, R. Najjar¹, S. Sethi¹, K. Lim¹, M. Gillespie¹, N. Badash¹, S. Jordan¹
¹Comprehensive Transplant Center, Cedars Sinai Medical Ctr, Los Angeles, CA, ²HLA Laboratory, Cedars Sinai Medical Ctr, Los Angeles, CA
*Purpose: IL-6/IL-6R have emerged as important targets for treating cAMR. Recent data show that long-term treatment can stabilize eGFR, reduce DSAs and result in a…
2022 American Transplant Congress
Utility of Genetic Testing in Kidney Transplant Evaluation
N. Singh¹, A. Palermini², A. Qamar¹, M. S. Naseer¹, H. Shokouh-Amiri¹, G. Zibari¹, D. Aultman¹, L. Beretich³, D. Luksic³, J. Gibson³, S. McCormick³, H. Tabriziani³, P. Billings³
¹Willis Knighton Physician's Network, John C. McDonald Regional Transplant Center, Shreveport, LA, ²Arkansas College of Osteopathic Medicine, Fort Smith, AR, ³Natera, Inc., Austin, TX
*Purpose: Genetic testing is an emerging tool in pre-kidney transplant (KT) evaluations for individuals with end-stage renal disease (ESRD). A known genetic etiology can inform…
2022 American Transplant Congress
Identification of Soluble and Cellular Biomarkers in Blood of End-Stage Patients Before Pediatric Liver Transplantation (pLTx)
E. Chichelnitskiy¹, L. Ruhl², I. Goldschmidt³, A. Karch⁴, L. Antiga⁵, D. Debray⁶, L. Hierro⁷, D. Kelly⁸, V. McLin⁹, E. Nicastro⁵, J. Pawlowska¹⁰, R. Mikolajczyk¹¹, U. Baumann¹², C. Falk¹³
¹Institute of Transplant Immunology, Hannover Medical School (MHH), Hannover, Germany, ²Institute of Transplant Immunology, MHH, Hannover, Germany, ³Division of Pediatric Gastroenterology and Hepatology, MHH; European Paediatric Liver Transplantation Network, Hannover, Germany, ⁴Research Group Epidemiological and Statistical Methods, Helmholtz Centre for Infection Research, Braunschweig; German Center for Infection Research, TTU-IICH Hannover; Institute for Epidemiology and Social Medicine, University of Münster, Münster, Germany, ⁵Ospedali Riuniti di Bergamo, Bergamo, Italy, ⁶Hôpital Necker-Enfants Malades, Paris, France, ⁷Hospital Infantil Universitario La Paz, Madrid, Spain, ⁸Birmingham Children's Hospital, Birmingham, United Kingdom, ⁹Service Spécialités Pédiatriques, Genève, Switzerland, ¹⁰Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, The Children’s Memorial Health Institute, Warsaw, Poland, ¹¹German Center for Infection Research, TTU-IICH Hannover; Institute of Medical Epidemiology, Biostatistics and Medical Informatics, University of Halle, Halle, Germany, ¹²Division of Pediatric Gastroenterology and Hepatology, MHH; Birmingham Children’s Hospital, UK; European Paediatric Liver Transplantation Network, Hannover, Germany, ¹³Institute of Transplant Immunology, MHH; German Center for Infection Research, TTU-IICH, Hannover, Germany
*Purpose: In the European multicentre “ChilSFree” study we aimed to identify soluble and cellular biomarkers in blood of various end-stage diseases before pLTx.*Methods: Using flow…
2022 American Transplant Congress
BK Polyomavirus Infection is Not Associated with a Meaningful Increase in Donor-Derived Cell-Free DNA
J. Fisher¹, K. Vieira¹, R. Burke², R. Gohh¹, R. Rogers¹
¹Warren Alpert Medical School of Brown University, Providence, RI, ²CareDx, Brisbane, CA
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) is a non-invasive measure of early allograft injury that has been clinically validated as a surveillance tool to detect antibody…