2013 American Transplant Congress
Human Thrombomodulin Regulates Complement Activation as Well as Coagulation in Xenoimmune Response
Introduction: Coagulation response is an important obstacle for a long-term xenograft survival. Thrombomodulin (TBM) has critical anticoagulant and anti-inflammatory effects as a component of the…2013 American Transplant Congress
Preoperative Amino Acid Free Diet Protects Against Hepatic Ischemia Reperfusion Injury, A
Background: Ischemia and reperfusion (I/R) injury is a serious and common complication after liver surgery and transplantation. We previously showed that three days of preoperative…2013 American Transplant Congress
Comparison of Gene Expression in Heart Beating and Non Heart Beating Donor Kidney, A
Experimental Surgery, Erasmus University Medical Centre, Rotterdam, Netherlands
The superior long-term survival of kidneys from living donors (LD) compared to brain death (BD) or non heart beating (NHB) donors is now well established.…2013 American Transplant Congress
MICA A5.1 Mutation Is an Immunodominant Factor, Promoting MICA Expression on Graft Endothelial Cells and MICA Alloimmunisation, and a Potential Risk Factor for Transplant Survival
Clinical findings suggest a role for donor MHC class I-related chain A (MICA) antigens expressed on transplant endothelial cells (ECs) in the alloimmune response. However,…2013 American Transplant Congress
Clinical Impact of an ACE Insertion/Deletion and Kinin B2 Receptor +9/-9 Polymorphisms in the Prognosis of Renal Transplantation
UNIFESP, Sao Paulo, Brazil; UNIFESP, Sao Paulo, Brazil; USP, Sao Paulo, Brazil
There is a consensus in the scientific literature that supports the importance of the kallikrein kinin and renin angiotensin systems in renal physiology, but notably…2013 American Transplant Congress
Three-Year Safety and Efficacy Outcomes in Kidney Transplant Patients Randomized to Steroid Avoidance or Maintenance Steroids with Early Intensified Dosing of Enteric-Coated Mycophenolate Sodium: The INFINITY Study
Short-term intensified enteric-coated mycophenolate sodium (EC-MPS) dosing may facilitate steroid avoidance (SA) after kidney transplantation.Methods. De novo kidney transplant recipients at low immunological risk (PRA…2013 American Transplant Congress
Integrated Analysis of MHC Class I-Like (MICA, HLA-E and EPCR) Genetic Diversity in Kidney Transplant Donors and Graft’s Endothelial Cell Phenotype
INSERM UMR1064, Nantes, France
Although, there is evidence for a role of MICA, HLA-E and EPCR in vascular transplant biology and immunology, genotyping is not routinely achieved and correlation…2013 American Transplant Congress
Micro RNA Biomarker Candidates for Vascular Invasion in Hepatocellular Carcinoma
INTRODUCTION: The presence of vascular invasion is known to be a strong predictor of hepatocellular carcinoma (HCC) recurrence after resection or transplant, but no clinically…2013 American Transplant Congress
Proteasome Inhibition Protects Steatotic Liver Graft through Modulation of the AMPK, Akt and mTOR Pathways
Background: Hepatic steatosis presents a major challenge in liver transplantation. Steatotic livers show an increased susceptibility to cold ischemia and reperfusion (CIR) injury. The mechanisms…2013 American Transplant Congress
Combined Costimulatory and OX40L Blockade Significantly Prolongs Transplant Survival in Mice and Non-Human Primates
Emory Transplant Center, Atlanta, GA; Juntendo University, Tokyo, Japan; Roche USA, New York, NY
Belatacept is the first clinically approved transplant immunosuppressant based on costimulatory blockade (CoB). Kidney transplant recipients treated with belatacept had improved long-term renal function, albeit…
American Transplant Congress abstracts