ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    Intrahepatic Cholangiocarcinoma (I-CC) or Mixed Hepatocellular-Cholangiocarcinoma (HCC-CC) in Patients Undergoing Liver Transplantation (LT). A Spanish Case Control Multicenter Study

    R. Charco, G. Sapisochin, C. Rodriguez-Lope, M. Gastaca, J. Ortiz de Urbina, R. Lopez-Andujar, F. Palacios, E. Ramos, J. Fabregat, J. Castroagudin, E. Varo, J. Pons, P. Parrilla, M. Gonzalez-Dieguez, M. Rodriguez, A. Otero, M. Vazquez, G. Zozaya, J. Herrero, G. Sanchez Antolin, B. Perez, R. Ciria, S. Rufián, Y. Fundora, J. Ferrón, A. Guiberteau, G. Blanco, M. Varona, M. Barrera, M. Suarez, J. Santoyo, J. Bruix

    Hosital Universitario Vall d'Hebron, Barcelona, Spain; Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain; Hospital Universitario de Cruces. Universidad del Pais Vasco, Bilbao, Spain; Hospital Universitario La Fe, Valencia, Spain; Hospital Universitraio de Bellvitge, L'Hospitalet de Llobregat, Spain; Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain; Hospital Virgen de la Arrixaca, Murcia, Spain; Hospital Central de Asturias, Oviedo, Spain; Hospital Universitario de A Coruña, La Coruña, Spain; Clinica Universitaria de Navarra, Pamplona, Spain; Hospital Rio Hortega, Valladolid, Spain; Hospital Universitario Reina Sofia, Córdoba, Spain; Hospital Universitraio Virgen de las Nieves, Granada, Spain; Hospital Universitario Infanta Cristina, Badajoz, Spain; Hospital Universitario Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, Spain ; Hospital Carlos Haya, Malaga, Spain

    Aim: to evaluate the outcome of patients with HCC-CC or I-CC at explant pathology after LT for suspected HCC.Methods:A case-control study 1:2. Study group(n=42) formed…
  • 2013 American Transplant Congress

    Pre-Transplant Immediately Early-1-Specific T-Cell Responses Provides Protection for CMV Infection after Kidney Transplantation

    O. Bestard, M. Lucia, E. Crespo, J. Cruzado, D. Palacio, E. Melilli, J. Torras, S. Gil-Vernet, J. Grinyó

    Renal Transplant Unit, Nephrology Department, Bellvitge University Hospital, Barcelona, Spain; Experimental Nephrology Department, IDIBELL, Barcelona, Spain; Nefrology Department, Hospital San Vicente de Paul, Bogota, Colombia

    Human cytomegalovirus (CMV) infection is still a major complication after kidney transplantation. Although it is well known that cytotoxic CMV-specific CD8+ T cells play a…
  • 2013 American Transplant Congress

    Soluble BAFF Levels Correlate with De Novo DSA Development and Progression to Chronic Active Antibody-Mediated Rejection in Pediatric Recipients of First Kidney Transplants

    P. Comoli, G. Quartuccio, M. Cioni, A. Parodi, I. Fontana, S. Basso, A. Magnasco, A. Tagliamacco, A. Nocera, M. Cardillo, F. Ginevri

    Pediatric Hematology/Oncology, IRCCS Fondazione S. Matteo, Pavia, Italy; Pediatric Nephrology, G. Gaslini Institute, Genova, Italy; Department of Surgery, IRCCS San Martino, Genova, Italy; Transplantation Immunology, Fondazione Cà Granda Ospedale Maggiore Policlinico, Milano, Italy

    De novo donor-specific antibody (dnDSA) development is associated with late/chronic active antibody-mediated rejection (CAMR) and graft failure in low-risk kidney recipients. It has been recently…
  • 2013 American Transplant Congress

    Disappearance of Immunoglobulin Producing Plasmablasts in Kidney Transplant Patients Is Associated with a Diminished Cytokine Producing Capacity by Peripheral Follicular T-Lymphocytes

    G. de Graav, M. Dieterich, N. Litjens, D. Hesselink, M. Betjes, W. Weimar, R. Bouamar, C. Baan

    Internal Medicin & Transplant Immunology, Erasmus MC, Rotterdam, South-Holland, Netherlands

    BACKGROUND Follicular T-helper cells (Thf-cells) play a pivotal role in the differentiation of B-cells into Ig secreting cells, i.e. plasmablasts. CD4+CXCR5+ T-cells are their peripheral…
  • 2013 American Transplant Congress

    E-Cad Promotes Liver Tissue Formation in Hepatic Differentiation of Mouse Embryonic Stem Cells through Regulating the Differentiation Progress

    A. Hu, X. He

    Department of Organ Transplantation, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guongdong Province, China

    Objective Until now, the hepatic differentiation of embryonic stem cells (ESCs) usually results in single cell lineage and could not form liver tissues. In this…
  • 2013 American Transplant Congress

    Late Extra-Hepatic Biliary Strictures after Liver Transplantation: First Evidence of Association with Pre-Existing Donor Specific Antibodies

    S. Loeb, E. Schadde, B. Ruesi-Elsener, P. Dutkowski, C. Pierre Alain, B. Jens

    Department of Surgery and Transplantation, University Hospital Zurich, Swiss HPB and Transplant Center, Zurich, Switzerland

    Late biliary strictures following liver transplantation are a major source of graft loss, and usually attributed to vascular problems. In many cases, however, vascular pathologies…
  • 2013 American Transplant Congress

    CCR2 Dependent Migration Is Absolutely Required for Myeloid Suppressor Cells To Protect Cell Transplants

    J. Qin, Y. Arakawa, J. Fung, S. Qian, L. Lu

    Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH; General Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH

    Whole organ transplantation gets great success, while the outcomes of cell transplants remain poor, suggesting a critical role of non-parenchymal cells in immune regulation. Through…
  • 2013 American Transplant Congress

    Kidney Transplantation: Pre and Post-Transplant Immunological Evaluation and Outcome of Recipients in Low, Medium, and High Risk of Rejection

    S. Abrahao, R. Oliveira, A. Pereira, F. Junior, M. Maciel, B. Vilela, C. Filho, R. Gontijo, E. Nascimento

    Laboratorio de Histocompatibilidade, Imunogenetica e Imunologia de Transplantes, IMUNOLABTx, Belo Horizonte, Minas Gerais, Brazil; Hospital das Clínicas, Universidade Federal de Minas Gerais, Beloo Horizonte, Minas Gerais, Brazil; MG Transplantes, FHEMIG, Belo Horiznte, Minas Gerais, Brazil; Instituto de Ensino e Pesquisas, Clínica de Transplantes, Santa Casa de Belo Horizonte, Belo Horizonte, Minas Gerais, Brazil

    Specific antibodies (AB) against donor (DSA) have a fundamental role in the mechanism of kidney (K) transplant rejection and represent one of the main barriers…
  • 2013 American Transplant Congress

    Prolonged Cardiac Allograft Survival Due to Treg Expansion in Recipient BAFF-Tg Mice

    M. Saito, G. Zhang, Y. Wang, M. Hu, S. Walters, J. Zhou, A. Sawyer, J. Chapman, S. Grey, S. Alexander

    Centre for Kidney Research, Children's Hospital at Westmead, Sydney, Australia; Centre for Transplant and Renal Research, Westmead Hospital, Sydney, Australia; Gene Therapy & Autoimmunity Group, Immunology and Inflammation Program, Garvan Institute of Medical Research, Sydney, Australia

    Background: B cell activation factor of the TNF family (BAFF) is considered to function as a proinflammatory cytokine. BAFF is crucial for B cell development…
  • 2013 American Transplant Congress

    Induction of Donor Specific Hyporesponsiveness in Kidney Transplantation Using Adoptive Transfer of Ex Vivo Induced Tolerogenic Cells

    I. Koyama, H. Bashuda, K. Seino, K. Kai, T. Murakami, A. Sannomiya, I. Nakajima, S. Fuchinoue, K. Okumura, S. Teraoka

    Tokyo Women's Medical University, Tokyo, Japan; Juntendo University, Tokyo, Japan; Hokkaido University, Sapporo, Japan; International University of Health and Welfare, Atami, Japan

    [Background] Anergic T cells generated ex vivo under conditions of co-stimulatory blockade are reported to have tolerogenic effects. According this finding, we have conducted the…
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