Abstracts Archive - Page 153 of 1683 - ATC Abstracts

2022 American Transplant Congress
Standard Induction with Basiliximab versus no Induction in Low Immunological Risk Kidney Transplant Recipients: Study Protocol for a Randomized Controlled Trial
A. Ajlan¹, H. Aleid¹, T. Ali¹, H. Joharji¹, Z. Alabdulkarim¹, T. Aburiash¹, K. Almeshari¹, A. Nazmi¹, Y. Shah¹, E. Devol¹, D. Alkortas¹, D. Broering¹, I. Alahmadi¹, A. Ullah¹, A. Alotaibi¹, A. Aljedai²
¹KFSHRC, RIYADH, Saudi Arabia, ²MOH, RIYADH, Saudi Arabia
*Purpose: To compare different induction therapeutic strategies with 2 doses of basiliximab vs. no induction in low immunologic risk kidney transplant recipients as per KFSHRC…
2022 American Transplant Congress
Liver Transplantation for Metabolic Liver Disease
J. Wothe, H. Bhatt, D. Vock, S. Schwarzenberg, V. Kirchner, S. Chinnakotla
University of Minnesota Medical School, Minneapolis, MN
*Purpose: Liver transplantation (LT) was initially developed as a therapy for liver diseases known to be associated with a high risk of near-term mortality. As…
2022 American Transplant Congress
Clinical Characteristics Of Serologic Non-responders To Covid-19 Booster Vaccination In A Cohort Of Solid Organ Transplant Recipients.
F. N. Zervou¹, K. Khalil¹, T. Lao¹, D. Wood², S. Jonche¹, A. Mattoo¹
¹Transplant Institute, NYU Langone Health, New York, NY, ²New York University Langone Health, Brooklyn, NY
*Purpose: The purpose of this study was to assess the clinical characteristics of serologic non-responders to COVID-19 booster vaccination in a cohort of solid organ…
2022 American Transplant Congress
Impact Of Antifungal Prophylaxis Discontinuation On Immunosuppression In Lung Transplant Recipients
R. Huntsman, K. Neuhaus
Pharmacy, Cleveland Clinic, Cleveland, OH
*Purpose: The purpose of this study is to characterize the impact of antifungal discontinuation on immunosuppressant levels and incidence of acute rejection and fungal infections…
2022 American Transplant Congress
Chimeric Antigen Receptor Regulatory T Cells (CAR-Tregs) Provide Significantly Greater Modulation of Alloimmune Responses Than Alternative Alloantigen-Specific Treg Strategies
A. S. Kurt¹, P. Ruiz¹, E. Kodela¹, G. Lombardi¹, M. Martinez-Llordella², A. Sanchez-Fueyo¹
¹King's College London, London, United Kingdom, ²Quell Therapeutics, London, United Kingdom
*Purpose: Conferring alloantigen-specificity to ex vivo expanded CD4+CD25+Foxp3+ Tregs increases their capacity to counteract effector alloimmune responses following adoptive transfer into transplant recipients. This has…
2022 American Transplant Congress
Single-Cell RNA Sequencing Identifies the Changes of Human Normal Kidney After Transplantation
G. Huang¹, H. Zhang¹, X. Chen¹, G. Zhao¹, J. Luo¹, S. Yang², J. Qiu¹
¹Organ Transplant Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China, ²Department of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China
*Purpose: We found that in all studies about kidney transplantation and single cell RNA sequencing (scRNA-seq), the native kidney rather than the transplanted kidney was…
2022 American Transplant Congress
PFIC- Outcome and Time to Transplant After Biliary Diversion According to Genetic Subtypes
M. Schulze¹, A. Sahloul², E. Lainka³
¹Organ Transplant Centre of Excellence, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia, ²Department of General, Visceral and Transplant Surgery, University Hospital Essen, Essen, Germany, ³Department of Pediatric Gastroenterology, University Hospital Essen, Essen, Germany
*Purpose: Progressive familial intrahepatic Cholestasis (PFIC) is a heterogeneous autosomal recessive disease characterized by progressive cholestasis, pruritus leading to liver injury. Surgical therapy aims in…
2022 American Transplant Congress
Prevalence of Mycophenolate Mofetil (MMF) Discontinuation and Outcomes in Pediatric Kidney Transplants (PKTX): A PNRC Study
A. Moudgil¹, K. Sgambat¹, E. Benoit², A. Jain³, M. Seifert⁴, C. Katsoufis⁵, L. Harshman⁶, A. Mansuri⁷, M. Somers⁸
¹Nephrology, Children's National Med. Ctr., Washington, DC, ²Nephrology, Boston's Children's Hospital, Boston, MA, ³Nephrology, Wayne State University, Troy, DC, ⁴Nephrology, The University of Alabama, Birmingham, AL, ⁵Nephrology, Holtz Children's Hospital, Miami, FL, ⁶Nephrology, University of Iowa, Iowa City, IA, ⁷Nephrology, Children's Hospital of Georgia, Augusta, GA, ⁸Nephrology, Boston Children's Hospital, Boston, MA
*Purpose: MMF is discontinued in PKTX for various reasons. In this Pediatric Nephrology Research Consortium (PNRC) study, we determined prevalence and reasons for MMF discontinuation…
2022 American Transplant Congress
Upregulation of Innate Immune Pathways is Associated with Increased Rejection in HIV-Infected Kidney Transplant Recipients
A. Zarinsefat¹, Y. Kelly¹, D. Dobi¹, G. Szabo¹, Z. Laszik¹, P. Stock¹, H. Braun²
¹UC San Francisco, San Francisco, CA, ²CA
*Purpose: Although kidney transplantation (KT) has become the standard of care for HIV+ patients with renal failure, early experiences revealed high acute rejection (AR) rates.…
2022 American Transplant Congress
Brief Human IL-2 Mutein Therapy Induces Foxp3+ T-Regulatory Cell Expansion and Donor-Specific Allograft Tolerance
L. Wang¹, G. J. Babcock², W. W. Hancock³
¹Pathology and Lab Medicine, Childrens Hospital of Philadelphia, Philadelphia, PA, ²Visterra, Inc., Waltham, MA, ³Pathology and Lab Medicine, University of Pennsylvania, Philadelphia, PA
*Purpose: New therapeutic approaches to the management of transplant recipients are warranted in efforts to improve outcomes.*Methods: We have engineered a modified human IL-2 protein…