ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    IL-33 Receptor Expression by Cardiac and Aortic Allografts Limits Immune Infiltration and Development of Vasculopathy

    Q. Liu, H. Turnquist

    Depart. of Surgery and Immunology, Starzl. Transpl. Inst., Univ. of Pittsburgh Sch. of Med., Pittsburgh, PA

    Overview: Studies have found administration of IL-33 triples the survival of MHC-mismatched murine heart transplants (HTx) in the absence of any immunosupression. These data are…
  • 2013 American Transplant Congress

    Transplant Certification and Quality Assessment: The Effect of Center Data Input Quality

    J. Tuttle-Newhall, K. Lentine, D. Axelrod, L. Ware, J. Milton, M. Schnitzler

    Center for Abdominal Transplantation, Saint Louis University, St. Louis; Dartmouth College, Lebanon; University of Texas, San Antonio

    Each transplant program in the United States is required to submit self-reported data to OPTN/UNOS to calculate a center’s performance. Currently, under the Conditions of…
  • 2013 American Transplant Congress

    Neutralization of IL-23 Is Protective Against Hepatic Cold Ischemia/Reperfusion (I/R) Injury

    J. Klune, S. Yokota, C. Bartels, N. Murase, Q. Du, D. Geller

    Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA

    Purpose: Interleukin-23 (IL-23) can activate inflammatory pathways such as CD4+ cell differentiation into IL-17 secreting Th17 cell type and increased production of IFNg leading to…
  • 2013 American Transplant Congress

    Risk Factors, Rejection and Infections Associated with Neutropenia in Solid Organ Transplantation: A Retrospective Study

    S. Clairoux, M. Fournier, J. Amiel, M. Tremblay, D. Vinh, C. Coursol, D. Thirion, M. Cantarovich

    Department of Pharmacy, McGill University Health Center (MUHC), Montreal, Canada; Faculty of Pharmacy, University of Montreal, Montreal, Canada; Multi-Organ Transplant Program, MUHC, Montreal, Canada; Division of Infectious Diseases, MUHC, Montreal, Canada

    Introduction: Neutropenia is relatively frequent after solid organ transplantation (SOT). Its risk factors have been scarcely studied and its consequences remain to be defined in…
  • 2013 American Transplant Congress

    Common Rejection Module (CRM) across Multiple Transplant Organs Identifies Novel Therapeutics for Treatment of Acute Rejection in Solid Organ Transplantation, A

    S. Roedder, P. Khatri, N. Kimura, K. De Vusser, A. Morgan, Y. Gong, M. Fischbein, R. Robbins, M. Naesens, A. Butte, M. Sarwal

    Transplantation Research BIOMARC Program, California Pacific Medical Center, Sutter Health, San Francisco, CA; Pediatrics, Division of Systems Medicine, Stanford University, Stanford, CA; Cardiothoracic Surgery, Stanford University, Stanford, CA; Nephrology, Leuven University, Leuven, Belgium

    We performed meta-analyses of eight datasets comprising whole genome microarray expression profiles on 236 graft biopsy samples from four types of transplanted organs (kidney, lung,…
  • 2013 American Transplant Congress

    For Cause Renal Biopsies Are Heterogeneous Irrespective of Clinical Presentation

    A. Cherukuri, S. Balasubramanian, P. Prasad, C. Angel, A. Lewington, C. Newstead, B. Clark, R. Baker

    St.James's University Hospital, Leeds, United Kingdom

    Deteriorating renal function either evidenced by a rise in serum creatinine or proteinuria remains the most important indication for a late transplant biopsy. Over the…
  • 2013 American Transplant Congress

    Age Disparities in Discussions about Kidney Transplantation among Dialysis Patients

    M. Salter, M. McAdams DeMarco, A. Law, B. Jaar, R. Parekh, D. Segev

    Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD; Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD; Division of Nephrology, Johns Hopkins School of Medicine, Baltimore, MD; Division of Nephrology, University of Toronto, Toronto, Canada

    BACKGROUND: Older patients show improved survival and quality of life following kidney transplantation (KT) compared to those who remain on dialysis, yet referral for KT…
  • 2013 American Transplant Congress

    Human Insulinoma Expression of E2F Reveals a Role in Beta-Cell Proliferation and Quiescence

    B. Rady, Y. Chen, P. Vaca Sanchez, Q. Wang, Y. Wang, J. Oberholzer

    Surgery - Transplant, University of Illinois at Chicago, Chicago, IL

    Reversal of diabetes in patients through islet cell transplant is quickly becoming a reality. However, cadaver organ donations, the current source of islets for transplant,…
  • 2013 American Transplant Congress

    Six Minute Walk Distance, Sarcopenia and Cardiopulmonary Assessment in Candidates for Liver Transplantation

    A. Yadav, Carpenter, Chang, Silva, Aqel, Byrne, Douglas, Vargas, Carey

    Transplant Hepatology, Mayo Clinic, Pheonix; Radiology, Mayo Clinic, Pheonix; Biostatistics, Mayo Clinic, Pheonix

    Evaluation for liver transplantation (LT) focuses on organ-specific testing intended to determine a candidate’s fitness for transplantation. However, simple tests of global physical function may…
  • 2013 American Transplant Congress

    Efficient Identification of All Grades of Antibody Mediated Rejection (AMR) and Mixed Rejection with a Unique Immunohistochemical Panel in Heart Transplant Patients

    P. Ruiz, S. Chaparro, E. Bauerlein, T. Bueno, B. Bednar, P. Rusconi, J. Jimenez, S. Pham

    Surgery, University of Miami, Miami, FL; Medicine, University of Miami, Miami, FL; Pediatrics, University of Miami, Miami, FL

    Antibody Mediated Rejection (AMR) following heart transplantation is increasingly recognized as a substantial complication that increases risk for graft failure, vasculopathy, and decreased recipient survival.…
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