2013 American Transplant Congress
Comprehensive Analyses of Inhibitory Effects of the mTOR Inhibitor Everolimus on the Differentiation into Subsets of Human T-Helper Cells and B Cells
Hiroshima University, Hiroshima, Japan
[Aim] Although the various potential benefits of everolimus over other immunosuppressants in organ transplantation have been described, the precise sensitivity of this drug to differentiation…2013 American Transplant Congress
Does an Isolated Positive B-Cell Crossmatch Carry Prognostic Information in Pediatric Heart Transplantation?
Cardiology, Boston Children's Hospital, Boston, MA
BACKGROUND: Recent data suggest that a positive T-cell crossmatch (CM) is associated with reduced post-heart transplant survival in children. An isolated positive B-cell flow crossmatch…2013 American Transplant Congress
Infection Related Kidney Discards
Background: Despite a long wait-list, transplant physicians always weigh the benefit of transplantation against the risk of accepting a potentially infected solid organ with resultant…2013 American Transplant Congress
Non-Invasive Imaging of Acute Allograft Rejection by Ultrasound Detection of Microbubbles Targeted to T-Lymphocytes in a Rat Renal Transplantation Model
ObjectiveWe propose anti-CD3-antibody-mediated contrast-enhanced ultrasonography using human T-lymphocytes for image-based diagnosis and differentiation of acute allograft rejection (AR) established in a rat renal transplantation model.MethodsAfter…2013 American Transplant Congress
Therapeutic Mycophenolic Acid Area-Under-Curve (MPA AUC) Levels Abolish Donor-Specific Antibody Formation in Established and De Novo Renal Transplant Patients
PinnacleHealth Transplantation, Harrisburg, PA
Background: Donor-specific antibody (DSA) formation is a key factor in development of antibody-mediated rejection and irreversible renal dysfunction. Prevention of DSA formation is critical, mandating…2013 American Transplant Congress
Conversion from Tacrolimus to Sirolimus May Increase the Risk of Cardiovascular Events in Kidney Transplant Recipients
Beth Israel Deaconess Medical Center, Boston, MA
Sirolimus (SRL) based immunosuppression regimens are used in kidney transplant recipients (KTRs) to avoid tacrolimus (TAC) toxicity. KTRs have a high risk of cardiovascular events…2013 American Transplant Congress
Effective Federal Advocacy: The Case for HIV-Infected Deceased Organ Donors
Johns Hopkins, Baltimore; UCSF, San Francisco
Background. HIV is no longer a contraindication to solid organ transplantation. For HIV-infected patients, HIV-infected deceased donors (HIVDD) could attenuate the organ shortage and waitlist…2013 American Transplant Congress
Gradual vs Rapid Withdrawal of Immunosuppression after Kidney Allograft Failure Results in Less Allosensitization, Decreased Rate of De-Novo Donor Specific Antibody and Reduced Need for Allograft Nephrectomy
Aim- Allosensitization after renal allograft failure is a major obstacle to re-transplantation.Withdrawal of immunosuppression after allograft failure is associated with sensitization. However, prolonged continuation of…2013 American Transplant Congress
Conversion from TAC-MMF to mTOR-TAC Immunosuppression in Kidney-Pancreas Transplantation Reduces the Incidence of BK Viremia
Surgery, The Methodist Hospital, Houston, TX; Pharmacy, The Methodist Hospital, Houston, TX
Background: BK nephropathy is an important cause of early graft loss after renal-pancreas transplantation. We sought to determine if conversion from tacrolimus/mycophenolate mofetil (TAC-MMF) to…2013 American Transplant Congress
Has Displaying KDPI in DonorNet® Led to a Spike in Discard Rates for Lower Quality Kidneys?
UNOS; Yale Med Ctr; Northwestern
Background: The Kidney Donor Profile Index (KDPI), derived from the Kidney Donor Risk Index (KDRI), began appearing in DonorNet with kidney offers on March 26,…
American Transplant Congress abstracts