Abstracts Archive - Page 151 of 1683 - ATC Abstracts

2022 American Transplant Congress
High-Level Pre-Transplant C-Peptide Among T2d Recipients of Simultaneous Pancreas and Kidney Transplants is Associated with Reduced Pancreatic Graft Function
S. Parajuli, D. Mandelbrot, D. Aufhauser, D. Kaufman, J. Odorico
University of Wisconsin, Madison, WI
*Purpose: Among selected patients with end-stage renal disease (ESRD) and type 2 diabetes (T2DM), simultaneous pancreas and kidney (SPK) transplants can be an effective option,…
2022 American Transplant Congress
Sars-cov-2 Antibody and T Cell Response After Vaccination with or without Intensified Immunosuppression Among Pediatric Renal Transplant Recipients
H. Pizzo¹, B. Shin², P. R. Soni³, S. Nadipuram³, J. Garrison², R. Zhang², S. C. Jordan², D. Puliyanda¹
¹Pediatric Nephrology, Cedars-Sinai Medical Center, Los Angeles, CA, ²Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA, ³Pediatric Infectious Disease, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: Recent data has shown poor antibody response to SARS-CoV-2 vaccination among adult kidney transplant (tx) recipients, with seroconversion ranging between 22%-58% after two mRNA…
2022 American Transplant Congress
Impact of Donor Quality on Outcomes for AKI and Non-AKI Kidneys with and without DGF
C. Jadlowiec¹, P. Budhiraja², R. Butterfield¹, M. Smith³, A. K. Mathur¹, A. Moss¹, H. Khamash², K. Reddy¹, R. Heilman²
¹Mayo Clinic Arizona, Phoenix, AZ, ²Division of Transplant Nephrology, Mayo Clinic Arizona, Phoenix, AZ, ³Division of Anatomic Pathology, Mayo Clinic Arizona, Phoenix, AZ
*Purpose: The relevance of DGF, and whether it is clinically significant, continues to be debated. Our aim was to compare post-transplant outcomes between AKI and…
2022 American Transplant Congress
Early Retrieval of the Right Kidney for Combined Heart and Kidney Transplantation is Feasible and Reduces Costs
H. Podder¹, R. McMillan², S. Yi², M. Hobeika³, D. Nguyen², E. Graviss², R. Whitehead², R. J. Knight⁴, M. Ghobrial², A. O. Gaber²
¹The Methodist Hospital, Houston, TX, ²Houston Methodist Hospital, Houston, TX, ³Houston Methodist, Houston, TX, ⁴Surgery, Houston Methodist Hospital, Houston, TX
*Purpose: Combined heart and kidney transplants (cHKT) have increased in recent years. Standard procurement practice often necessitates kidney extraction and packaging after the heart team…
2022 American Transplant Congress
Antibody-Mediated Allograft Rejection is Associated with an Increase in Peripheral Differentiated Cd28-cd8+ T Cells – Analyses of a Cohort of 1032 Kidney Transplant Recipients
H. L. Mai¹, N. Degauque¹, S. Le Bot¹, M. Rimbert¹, K. Renaudin¹, R. Danger¹, F. Le Borgne², C. Kerleau¹, F. Delbos³, M. Giral¹, S. Brouard¹
¹UMR 1064 - CRTI, INSERM - CHU de Nantes, Nantes, France, ²UMR 1046 - SPHERE, INSERM - IDBC-A2COM, Nantes, France, ³Etablissement Français du Sang (EFS) - CHU de Nantes, Nantes, France
*Purpose: CD28-CD8+ T cells represent a differentiated CD8+ T cell subset that is found to be increased in various conditions associated with chronic antigenic stimulation…
2022 American Transplant Congress
Laparoscopic Kidney Transplantation : A Lost Art ?
F. J. Osella¹, I. Cabrera¹, J. Walther², L. Leon², O. Guardia², M. Rial²
¹Surgery - Kidney and Pancreas Trasplant, ITAC by Diaverum, Buenos Aires, Argentina, ²Nephrology, ITAC by Diaverum, Buenos Aires, Argentina
*Purpose: Laparoscopic surgery and currently robot-assisted surgery have transformed the current surgery paradigm, showing a lower systemic inflammatory response, less post-operative pain, smaller incisions, shorter…
2022 American Transplant Congress
Combined Metagenomic Viral Detection and Donor-Derived Cell-Free DNA Quantification for Solid Organ Transplant Recipients
R. Sinha¹, C. Rebello², E. Bixler¹, A. Al-Turck¹, A. Berg¹, J. Friedewald², S. Kleiboeker¹
¹Eurofins Viracor, Lees Summit, MO, ²Northwestern University, Chicago, IL
*Purpose: Solid organ transplant recipients are predisposed to opportunistic infections, and current viral diagnostic methods focus on sensitive detection of single pathogens by qPCR. However,…
2022 American Transplant Congress
Ikaros-SIRT1 Signaling Axis Regulates Macrophage Pyroptosis and Ischemia-Reperfusion Injury (IRI) in Mouse and Human Liver Transplantation
K. Kadono¹, H. Hirao¹, H. Kojima¹, K. J. Dery¹, X. Li², J. Kupiec-Weglinski¹
¹UCLA Medical Center, Los Angeles, CA, ²NIEHS, Durham, NC
*Purpose: Although Ikaros is a well-established regulator of lymphopoiesis, its role in myeloid cells and organ IRI remains unclear. We recently reported that the SIRT1-mediated…
2022 American Transplant Congress
Tacrolimus Metabolizer Heterogeneity within Caucasian Kidney Transplant (KT) Recipients
J. Sanchez-Garcia¹, N. Oliver¹, D. Morris¹, A. Raza¹, L. Lindberg¹, S. LeCorhick¹, T. Srinivas², S. Anand¹
¹Intermountain Medical Center, Murray, UT, ²CareDX, South San Francisco, CA
*Purpose: Weight-based tacrolimus (T) dosing is the standard in post-transplant KT. African-Americans and Caucasians differ in their metabolizer phenotype for T. However, two morphometrically similar…
2022 American Transplant Congress
Apoptotic Exosome-Like Vesicles Aggravate Inflammation and Renal Injury After Ischemia-Reperfusion
I. Kaci¹, S. Lan¹, H. Kim¹, A. Karakeussian Rimbaud¹, F. Migneault¹, J. Turgeon¹, N. Patey², M. Dieudé¹, M. Hébert¹
¹Research Centre, Centre hospitalier de l’Université de Montréal, Montreal, QC, Canada, ²Research Centre, Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada
*Purpose: Ischemia-reperfusion injury (IRI) is a common cause of acute kidney injury (AKI) and chronic kidney disease (CKD). Damage to microvascular peritubular capillaries (PTC) is…