Abstracts Archive - Page 149 of 1683 - ATC Abstracts

2022 American Transplant Congress
Delivery of Extracellular Matrix Targeted Regulatory T Cells by Novel Nanofiber Coatings for Transplantation Therapies
L. Gallon¹, J. K. Carrow², J. He¹, Y. Sambandam¹, X. Lai¹, J. Mathew¹, L. C. Palmer², J. R. Leventhal¹, Z. Zhang¹, S. I. Stupp²
¹Surgery - Transplant, Northwestern University, Chicago, IL, ²Simpson Querrey Institute, Northwestern University, Chicago, IL
*Purpose: Regulatory CD4+CD25+FOXP3+ T cells (Tregs) have been shown to induce tolerance in transplantation models and can mitigate transplant rejection or injury following ischemic reperfusion…
2022 American Transplant Congress
Complement 5 Regulation Ameliorates Antibody-Mediated Rejection After Liver Transplantation in Rats
T. Tajima¹, K. Hata¹, J. Kusakabe¹, H. Miyauchi¹, X. Zhao¹, S. Kageyama¹, T. Okamoto¹, Y. Wang², E. Hatano¹
¹Dept. of HBP Surgery & Transplantation, Kyoto University, Kyoto, Japan, ²Alexion Pharmaceuticals Inc., New Haven, CT
*Purpose: Antibody-mediated rejection (AMR) is a refractory rejection after donor-specific antibody (DSA)-positive or blood-type incompatible organ transplantation. Since AMR significantly deteriorates transplant outcomes, there is…
2022 American Transplant Congress
Surveillance of Donor-Derived Cell-Free DNA Throughout Treatment of Acute Rejection in Pediatric Renal Transplant Recipients
K. A. Klein¹, E. L. Kincaide¹, M. Fei², A. M. Bell², M. Y. Arar³, D. Ranch³
¹Pharmacotherapy Education and Research Center, UT Health San Antonio, San Antonio, TX, ²CareDx, Inc., Brisbane, CA, ³Long School of Medicine, UT Health San Antonio, San Antonio, TX
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) is a dynamic plasma biomarker for allograft rejection with limited data in pediatric renal transplant recipients and few reports describing…
2022 American Transplant Congress
Perfusate Metabolites and Association with Pump Perfusion and Allograft Failure
R. X. Liu¹, N. Koyawala², H. T. Philbrook², I. Hall³, P. Reese⁴, S. Mohan⁵, M. Doshi⁶, C. Parikh¹
¹Johns Hopkins University School of Medicine, Baltimore, MD, ²Department of Medicine, Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD, ³University of Utah School of Medicine, Salt Lake City, UT, ⁴University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ⁵University of Columbia Vagelos College of Physicians & Surgeons, New York, NY, ⁶University of Michigan, Ann Arbor, MI
*Purpose: While hypothermic machine perfusion (HMP) is associated with improved kidney graft viability, the exact biological mechanisms underlying this association are unknown. The goal of…
2022 American Transplant Congress
Engineered IL-2 Plus Calcineurin Inhibitor Synergistically Expands Regulatory T Cells Transduced with Engineered IL-2 Receptor and Facilitates Establishment of Transplantation Tolerance
T. Hirai¹, P. Lin², T. L Ramos², K. Garcia³, R. S Negrin²
¹Urology, Tokyo Women's Medical University, Tokyo, Japan, ²Blood and Marrow Transplantation, Stanford University, Stanford, CA, ³Molecular and Cellular Physiology and Structural Biology, Stanford University, Stanford, CA
*Purpose: Clinical trials for regulatory T cell (Treg) therapy in organ transplant has shown promising results. However, it is still under the debate which drugs…
2022 American Transplant Congress
Real-Time Application of Deep Learning in Diagnosis of Graft Fibrosis After Liver Transplantation Using Longitudinal Data
A. Azhie¹, D. Sharma², P. Sheth¹, W. Xu³, M. Bhat¹
¹Ajmera Transplant Program, University Health Network, Toronto, ON, Canada, ²Department of Biostatistics, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada, ³Biostatistics Division, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
*Purpose: Graft fibrosis develops insidiously in liver transplant recipients and is associated with worse survival. Early detection of fibrosis is essential to avoid further progression…
2022 American Transplant Congress
Survival of the Fittest: The Rise in Liver Transplantation for Alcoholic Related Disease
K. Lau¹, A. M. Fagenson¹, L. Szeto², S. Gingipally², K. Forde²
¹Surgery, Temple University Hospital, Philadelphia, PA, ²Medicine, Temple University Hospital, Philadelphia, PA
*Purpose: The number of Orthotopic Liver Transplantation (OLT) performed for hepatitis C infection have decreased recently due to direct acting antiviral therapy. However, the number…
2022 American Transplant Congress
Tolerant B Cells Suppress Memory B Cells in a Donor Specific Manner in CoB Mediated Transplantation Tolerance
S. Durgam¹, D. Yin¹, M. Alegre², A. Chong¹
¹Surgery, section of transplant immunology, University of Chicago, Chicago, IL, ²Medicine, section of rheumatology, University of Chicago, Chicago, IL
*Purpose: We previously reported that B cells in recipients made tolerant to fully mismatched heart allografts by anti-CD154+donor spleen cells (CoB) become dysfunctional in their…
2022 American Transplant Congress
Incidence of Viral Infections in Kidney Transplant Recipients Using Reduced Induction and Steroid Free Maintenance Immunosuppression
P. Dunton, L. Von Stein, H. Winters, A. Schenk, T. Pesavento, R. M. Smith, K. Schnelle
Ohio State University Wexner Medical Center, Columbus, OH
*Purpose: Viral infections (VI) commonly occur in the post-transplant period and higher cumulative doses of rATG have been correlated with higher rates of infection. However,…
2022 American Transplant Congress
Inferior Kidney Transplant Outcomes in Young Adults Transplanted as Children
K. Deville, F. Rosenblum, D. R. Kelly, M. Seifert
UAB School of Medicine, Birmingham, AL
*Purpose: Adolescence (age 13-17 years) has been identified as a high-risk age interval for pediatric kidney transplant recipients, with accelerated rates of late acute rejection…