Abstracts Archive - Page 149 of 1683 - ATC Abstracts

2022 American Transplant Congress
Personalized Medicine Using Next-Generation Sequence for Kidney Transplant Recipients
J. Sanchez-Garcia, D. Morris, E. Darling, M. Dantis-Tan, J. Olson, K. Gaid, A. Raza, S. Anand
Intermountain Medical Center, Murray, UT
*Purpose: Tissue diagnosis definitely drives therapeutic and prognostic decisions amongst patients with chronic kidney disease (CKD). However, patients with CKD often present late in the…
2022 American Transplant Congress
Surveillance with Protocol Biopsies for Rejection Significantly Impacts Survival Following Intestine Transplant
J. R. Sherwood¹, Y. Ichkhanian², N. Beltran³, S. Nagai³, S. Jafri⁴
¹Wayne State School of Medicine, Detroit, MI, ²Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, ³Department of Transplant Surgery, Henry Ford Hospital, Detroit, MI, ⁴Division of Gastroenterology and Hepatology, Henry Ford Hospital, Detroit, MI
*Purpose: Frequent surveillance biopsy is required on the first month post intestinal transplant(IT) due to high-risk of acute rejection. However, the utility and the frequency…
2022 American Transplant Congress
Intrinsic DEPTOR Activity Modulates Treg Subset Differentiation
J. Wedel¹, M. Maslyar¹, B. Alsairafi¹, S. Kong², D. M. Briscoe¹
¹Transplant Research Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, ²Computational Health Informatics Program, Boston Children's Hospital, Harvard Medical School, Boston, MA
*Purpose: We have previously reported that DEPTOR activity within CD4+Foxp3+ Tregs increases immunomodulation following transplantation. DEPTOR functions by both stabilization of Foxp3 expression through epigenetic…
2022 American Transplant Congress
Dynamic Changes in Titer and Specificity Autoantibodies in Chronic Bm12 to B/6 Kidney Rejection
I. Sayin¹, D. Yin¹, D. Ghosh², M. Clark², A. Chong¹
¹Department of Surgery, University of Chicago, Chicago, IL, ²Department of Medicine, University of Chicago, Chicago, IL
*Purpose: Loss of autoreactive B cell tolerance and production of non-HLA autoantibodies have been observed in patients undergoing chronic rejection, however, how autoreactive B cells…
2022 American Transplant Congress
Renal Allograft Rejection: New Paradigms in the T Cell Landscape Revealed by Single Cell RNAseq Analysis
T. Shi¹, A. Burg¹, K. Roskin², J. Rush³, B. Haraldsson³, A. Shields⁴, R. Alloway⁴, E. Woodle⁵, D. Hildeman¹
¹Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Novartis Pharmaceuticals AG, Basel, Switzerland, ⁴Internal Medicine, University of Cincinnati, Cincinnati, OH, ⁵Surgery, University of Cincinnati, Cincinnati, OH
*Purpose: Defining the T cell landscape in renal allograft rejection (RAR) transcriptomically at the single cell level remains to be achieved. The purpose of the…
2022 American Transplant Congress
Il-33 Induced Regulatory Macrophages Inhibit Transplantation Immune Rejection by Inducing Tregs
J. Wu, F. Zhang, W. Wang
Beijing Chaoyang Hospital, Beijing, China
*Purpose: The occurrence of acute and chronic rejections after transplantation are key factors that affect the survival of the recipients. Induction of transplantation immune tolerance…
2022 American Transplant Congress
Sarcopenia and Testosterone Deficiency with Chronic Liver Disease; Post-Liver Transplant Utility of Short Term Testosterone Replacement Therapy
A. Jain¹, D. Haussner²
¹Penn State Health Milton S. Hershey Medical Center, Hershey, PA, ²Presbyterian, New York, NY
*Purpose: Chronic liver disease is often associated with testosterone deficiency. However, testosterone therapy does not improve survival. So far, after a successful liver transplant (LTx),…
2022 American Transplant Congress
Impact of Cytomegalovirus and BK Virus Infection on Clinical Outcomes in Kidney Transplant Recipients
W. Park, J. Yang, J. Kwon, J. Lim, Y. Kim, J. Paek, K. Jin, S. Han
Division of Nephrology, Department of Internal Medicine, Keimyung University School of Medicine, Keimyung University Dongsan Hospital, Daegu, Korea, Republic of
*Purpose: Cytomegalovirus (CMV) or BK virus (BKV) infection is one of the important opportunistic infections in kidney transplant recipients (KTRs). CMV or BKV infection can…
2022 American Transplant Congress
Temporal Changes in the Peripheral Immune Profile of Acute Rejection Highlight New Mechanisms of Alloimmunity and Potential Non-Invasive Biomarkers of Rejection in Pediatric Liver Transplantation
D. N. Sarode¹, B. Rocque¹, A. Barbetta¹, P. Singh¹, C. Goldbeck¹, C. Weaver², O. Akbari¹, R. Kohli², J. Emamaullee¹
¹University of Southern California Keck School of Medicine, Los Angeles, CA, ²Children's Hospital Los Angeles, Los Angeles, CA
*Purpose: Acute rejection (AR) is common in pediatric liver transplantation (LT) and can impact late graft loss. Immune subpopulations mediating AR in LT have not…
2022 American Transplant Congress
Top Molecules Associated with CLAD in Lung Transplants Are Shared Between Mucosal Biopsies, Transbronchial Biopsies, and Kidney Transplant Biopsies at Risk of Progression
M. Mackova¹, K. Halloran², P. F. Halloran¹, .. and the INTERLUNG Study Group³
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²University of Alberta, Edmonton, AB, Canada, ³., ., AB, Canada
*Purpose: Chronic lung allograft dysfunction (CLAD) is a physiologic state with grave consequences for progression to failure but cannot be diagnosed by biopsy histology. We…