Abstracts Archive - Page 1483 of 1683 - ATC Abstracts

2015 American Transplant Congress
Intermittent High Dose Intravenous Immunoglobulin as Treatment for Donor Specific Antibodies in Renal Transplant Recipients
P. Bolin,¹ K. Parker,² F. Rana,¹ W. Bryant,¹ P. Jawa,¹ R. Harland.³
¹Internal Medicine, East Carolina University, Brody School of Medicine, Greenville, NC; ²Vidant Medical Center, Greenville, NC; ³Surgical Immunology and Transplantation, East Carolina University, Brody School of Medicine, Greenville, NC.
Background: Donor-specific HLA antibody (DSA) formation in post-renal transplant patients is associated with chronic rejection and graft failure. Previous studies in our population have indicated…
2015 American Transplant Congress
Preformed IgA Antibodies to B2-Glycoprotein Is an Indepedent Risk Factor for Graft Thrombosis and Early Graft Loss After Renal Transplantation
J. Morales,¹ M. Serrano,³ J. Martinez,² D. Perez,² M. Sevilla,² A. Amdres,³ E. Gonzalez,³ E. Paz-Artal,² A. Serrano.²
¹Research Institute, hospital 12 de Octubre, Madrid, Spain; ²Immunology, Hospital 12 de Octubre, Madrid, Spain; ³Nephrology, Hospital 12 de Octubre, Madrid, Spain.
Vessel trombosis represent the first cause of early graft loss (EGL)alter renal transplantation (RT). Our group recently described that preformed IgA antibodies to B2-Glycoprotein (…
2015 American Transplant Congress
CPRA Values Are Substantially Increased for Some Candidates Subsequent to Inclusion of Unacceptable C-locus (UA-C) Antigens While Listing Practices Remain Unchanged
A. Kucheryavaya,¹ R. Bray,² A. Miller,¹ D. Tyan.³
¹UNOS, Richmond; ²Emory University Hospital, Atlanta; ³Stanford University, Palo Alto.
Background: CPRA is the % of deceased donors expected to have one or more UAs with a given candidate. Prior to 12/5/13, candidates with UA-C…
2015 American Transplant Congress
Gene Expression Profiles Indicate That Many Discarded Kidneys Are Potentially Transplantable
K. Famulski,¹ S. Niederhaus,² J. Reeve,¹ J. Bromberg,² P. Halloran.
¹University of Alberta, Edmonton, Canada; ²University of Marlyland, Baltimore.
We previously showed that the molecular kidney injury-repair response (AKI score) in implantation core biopsies (Bx) predict future graft function better than histology. This could…
2015 American Transplant Congress
Comparative Survival Benefits and Costs of an Eplet and Broad Antigen Based Matching System in Deceased Donor Kidney Transplant Allocation Among Indigenous Australians
H. Do Nguyen,¹ G. Wong,^2,3 J. Chapman,² J. Craig,^2,3 L. D'Orsogna,⁴ W. Lim.^1,5
¹School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia; ²Nephrology, The Children's Hospital at Westmead, Sydney, New South Wales, Australia; ³School of Medicine, University of New South Wales, Sydney, New South Wales, Australia; ⁴Clinical Immunology, Royal Perth Hospital, Perth, Western Australia, Australia; ⁵Renal Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
Aim: To compare the benefits and costs of incorporating an eplet-based matching algorithm to the current allocation of deceased donor kidneys to indigenous Australians.Background: The…
2015 American Transplant Congress
Effect of Distinct Immunosuppressive Protocols On the Profile of Cytokines Expression in Renal Transplant Recipients of Extended Criteria Donor Kidneys
C. Montoro Mazeti,¹ C. Zangrossi Dezotti,¹ I. Fernandes-Charpiot,^1,2 H. Caldas,¹ M. Baptista,^1,2 M. Abbud Filho.^1,2,3
¹Laboratory of Immunology and Experimental Transplantation, Sao Jose do Rio Preto Medical School, Sao Jose do Rio Preto, SP, Brazil; ²Department of Medicine, Division of Nephrology, Sao Jose do Rio Preto Medical School, Sao Jose do Rio Preto, SP, Brazil; ³Urology and Nephrology Institute, Urology and Nephrology Institute, Sao Jose do Rio Preto, SP, Brazil.
Background: Transplant recipients (RTx) of kidneys classified as extended criteria (ECD) seems to have worst outcomes when compared with RTx of standard kidneys (SCD) and…
2015 American Transplant Congress
Angiopoietin-2 Associates With Graft Failure and Mortality in Renal Transplant Recipients
W. Westendorp,¹ C. Keyser,² E. van den Berg,² C. Krikke,¹ H. van Goor,³ S. Bakker,² H. Leuvenink.¹
¹Surgery, Groningen Transplant Center, University Medical Center Groningen, Groningen, Netherlands; ²Nephrology, Groningen Transplant Center, University Medical Center Groningen, Groningen, Netherlands; ³Pathology, University Medical Center Groningen, Groningen, Netherlands.
Angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2) are involved in stabilizing the vascular endothelium and may play a role in premature mortality and graft failure in renal…
2015 American Transplant Congress
Correlation Between Level of Biomarkers Measured in Perfusate of Machine-Preserved ECD/DCD Kidneys and Post-Transplant Graft Function
E. Ablorsu,¹ S. Zouwail,² P. Laftsidis,¹ B. Cook,¹ L. Szabo.¹
¹Cardiff Transplant Unit, University Hospital for Wales, Cardiff, United Kingdom; ²The Medical Biochemistry and Immunology Department, University Hospital for Wales, Cardiff, United Kingdom.
Background:DCD and ECD kidneys are associated with higher risk of failure compare to SCD kidneys. Therefore we see increasing need to identify sensitive tool to…
2015 American Transplant Congress
Profound Effect of HDAC2 Deletion on Renal Ischemia-Reperfusion Injury Is Intrinsic to the Kidney and Includes Protection Against Cold Ischemia
D. Aufhauser, Jr.,¹ Z. Wang,¹ S. Cheraghlou,¹ T. Bhatti,² W. Hancock,^2,3 M. Levine.^1,4
¹Department of Surgery, University of Pennsylvania, Philadelphia, PA; ²Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA; ³Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; ⁴Department of Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA.
Introduction: Histone/protein deacetylases (HDACs) regulate gene expression by modifying chromatin accessibility and protein acetylation. We have previously found that deletion of HDAC2 protects from renal…
2015 American Transplant Congress
Human Bone Marrow Mesenchymal Stem Cell-Derived Hepatocytes Express TIMP-4 and Follistatin
J. Li,¹ J. Xin,¹ W. Ding,² S. Hao,¹ L. Jiang,¹ Q. Zhou,¹ T. Wu,¹ D. Shi,¹ L. Li.¹
¹State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, HangZhou, China; ²Systems Biology Division, Zhejiang-California International Nanosystems Institute, Zhejiang University, HangZhou, China.
Human bone marrow mesenchymal stem cell (hBMSC) transplantation has been expected to be an alternative regenerative technique for liver diseases. However, the mechanism by which…