Abstracts Archive - Page 1478 of 1683 - ATC Abstracts

2015 American Transplant Congress
OX40 Gene: A Potential Target for the Care of Chronic T-Cell Mediated Rejection (TCMR)
F. Schena,¹ C. Curci,¹ F. Sallustio,¹ M. Trpevski,¹ G. De Palma,¹ M. Fiorentino,² M. Rossini,² M. Quaglia,³ E. Bozzola,³ S. Zanini,⁴ L. Furian,⁴ A. Toscano,⁵ E. Gallo,⁶ L. Gesualdo,² P. Stratta,³ P. Rigotti,⁴ F. Citterio,⁵ L. Biancone.⁶
¹C.A.R.S.O. Consortium, Valenzano, Italy; ²University of Bari, Bari, Italy; ³A.O.U. Maggiore della Carità, Novara, Italy; ⁴University of Padova, Padua, Italy; ⁵Cattolica Sacro Cuore University, Rome, Italy; ⁶University of Torino, Turine, Italy.
Introduction:TCMR is characterized by the reduction of vessel lumen with marked intimal thickening, fibrous hyperplasia and a strong component of leukocyte infiltrate. Aim of our…
2015 American Transplant Congress
Myeloid Cell-Specific Heme Oxygenase-1 Is Crucial for Hepatoprotection in Liver Ischemia-Reperfusion Injury
K. Nakamura,¹ M. Zhang,² B. Ke,¹ R. Busuttil,¹ J. Araujo,² J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, University of California, Los Angeles, Los Angeles, CA; ²Medicine, Division of Cardiology, University of California, Los Angeles, Los Angeles, CA.
Background and Aim: Heme oxygenase-1 (HO-1), an anti-oxidant enzyme, is essential in tissue resistance against innate immunity driven ischemia-reperfusion injury (IRI). Our group was the…
2015 American Transplant Congress
T Cell Specific Up Regulation of Nrf2 Regulated Antioxidant Response Protects from Kidney Ischemia Reperfusion Injury in Mice
S. Noel,¹ M. Martina,² S. Bandapalle,¹ S. Reddy,³ L. Racusen,² A. Hamad,² H. Rabb.¹
¹Department of Medicine, Johns Hopkins University, Baltimore, MD; ²Department of Pathology, Johns Hopkins University, Baltimore, MD; ³Department of Pediatrics, University of Illinois, Chicago, IL.
Background: T lymphocytes mediate important pathophysiological roles during ischemia reperfusion injury (IRI). Transcription factor Nrf2 is protective during experimental kidney IRI and thought to be…
2015 American Transplant Congress
T-bet Directs nTreg Homing Into Draining Lymph Nodes by Regulation of Specific Migration and Adhesion Receptors
Y. Xiong, S. Ahmad, D. Iwami, C. Brinkman, J. Bromberg.
University of Maryland, Baltimore.
Background: The transcription factor T-bet endows Treg with the functional and migratory properties to suppress Th1 inflammation. Previously, we showed that nTreg homing into draining…
2015 American Transplant Congress
IFNγ Is Required for nTreg Afferent Lymphatic Migration
S. Ahmad, Y. Xiong, C. Brinkman, J. Bromberg.
Surgery, University of Maryland, Baltimore, MD.
Background: Natural Treg (nTreg) must migrate from graft to draining lymph node (LN) to prolong islet allograft survival, and we previously showed that the transcription…
2015 American Transplant Congress
Identification of Mouse Tolerogenic B Cells Expressing PD-L1/PD-L2 in B-1a Subset
T. Hirose,^1,2 Y. Tanaka,¹ H. Sakai,¹ Y. Sasaki,¹ H. Ohdan.¹
¹Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan; ²Renal and Genitourinary Surgery, Hokkaido University, Sapporo, Hokkaido, Japan.
Donor lymphocyte infusion (DLI) has been shown to induce donor-specific hyporesponsiveness or even immune-tolerance among alloreactive T cells in different organ transplantation models. However, the…
2015 American Transplant Congress
CD28 Saturation by FR104, a Non-Activating CD28 Antagonist Fab in a Non-Human Primate Cardiac Allograft Model
W. Sun,¹ A. Azimzadeh,¹ G. Braileanu,¹ T. Zhang,¹ D. Amoako,¹ L. Burdorf,¹ B. Vanhove,² R. Pierson III.
¹Dept of Surgery, University of Maryland School of Medicine, Baltimore, MD; ²INSERM U643, Nantes, France.
Background: Targeting CD28 costimulation pathway with a selective antagonist is a promising approach in tolerance induction. The extent to which novel therapeutic antibodies reach their…
2015 American Transplant Congress
Inhibition of T Cell Metabolism Reveals a New Approach to Preventing Graft Rejection
C.-F. Lee,^1,2 Y.-C. Lo,² G. Furtmüller,³ B. Oh,³ V. Andrade-Oliveira,² A. Thomas,⁴ G. Brandacher,³ J. Powell.²
¹Department of Liver and Transplantation Surgery, Chang-Gung Memorial Hospital-Linkou Branch, Taoyuan, Taiwan; ²Sidney-Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD; ³Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; ⁴Brain Science Institute, Neurotranslational Program Johns Hopkins University School of Medicine, Baltimore, ND.
Upon antigen recognition and co-stimulation, T cells up-regulate the metabolic machinery necessary to proliferate and sustain effector function. Hallmarks of this response include a switch…
2015 American Transplant Congress
Liver-Specific Transcription Factor ATF5 Participates in Regulation of IFN-γ/B7-H1 Signaling Pathway in Liver Mesenchymal Cells
G.-Q. Shen, L. Wang, J. Fung, L. Lu, S. Qian.
Immunology, Lerner Research Institute; 2General Surgery, Digestive Disease Insttute, Cleveland Clinic, Cleveland, OH.
Liver transplant tolerance was initially discovered in pigs, rats and mice. A recent paper reviewed ∼400 liver transplant patients worldwide who had undergone weaning of…
2015 American Transplant Congress
Aldosterone Acts Directly On T Cells, and Promotes Production of Inflammatory Cytokines
J. Bagley, S. Begum, J. Iacomini.
Department of Developmental, Molecular and Chemical Biolgy, Tufts University Medical School, Boston.
Aldosterone is a mineralocorticoid hormone involved in the regulation of blood electrolyte concentration, blood pressure and blood volume. The primary receptor for aldosterone is the…