2015 American Transplant Congress
Activation and Sequestration of Platelets During Xenogeneic GalTKO.hCD46 Pig Lung Perfusion Is Primarily Mediated By GPIb, GPIIb/IIIa, and VWF
Background: Xenogeneic pig lung perfusion with human blood leads to the initiation of rejection mechanisms that are associated with the immediate sequestration of circulating platelets.…2015 American Transplant Congress
Anti-LG3 Antibodies Aggravate Ischemia-Reperfusion Injury
Ischemia-Reperfusion Injury (IRI) is a significant cause of renal allograft dysfunction and a risk factor for poor long-term graft outcomes. Microvascular injury is an important…2015 American Transplant Congress
Combined Anti-IL6R and CTLA4Ig Therapy Attenuates Recall Alloantibody Responses in a Mouse Model of HLA Sensitization
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
[bald]Background[/bald] We previously reported that IL-6 inhibition by anti-IL6R antibody (mMR16-1) or CD28 pathway inhibition using CTLA4Ig (abatacept) reduced recall alloantibody responses in a mouse…2015 American Transplant Congress
Antibody-Mediated Rejection Is Associated With Higher Serum Levels of CXCL13 and CCL21 in Renal Transplant Patients and Altered By Bortezomib/Rituximab Treatment
In renal transplant patients (pts), B- and plasma cells (PC) are crucial for donor-specific HLA antibody (DSA) formation. The underlying mechanisms, which lead to B…2015 American Transplant Congress
Donor Dendritic Cells – Potential New Therapeutic Target in Transplantation
Background: It is clear that T cells play a central role in the process of allograft rejection. However, donor dendritic cells (dDC) are the most…2015 American Transplant Congress
B-Cell Activation in Acute Kidney Injury and Delayed Graft Function
Background:Acute kidney injury (AKI) is a relevant complication after kidney transplantation and also after non-renal solid organ transplantation. Growing evidence points towards an important role…2015 American Transplant Congress
Antibody-Induced Platelet Activation Increases Allograft Hyaluronan Fragmentation
Antibodies to MHC class I antigens have been shown to activate endothelial cells to release von Willebrand factor (vWf) and P-selectin from storage granules. These…2015 American Transplant Congress
mTOR Inhibitors Reduce the Endothelial Transmigration of Leukocytes After Ischemia
ObjectivemTOR inhibitors Everolimus and Sirolimus are currently used as maintenance immunosuppressive agents to prevent rejection of solid transplanted organs. Episodes of transplant rejection and graft…2015 American Transplant Congress
Pancreas Transplant Sera Improves the Function and Proliferation of Endothelial Cells
Transplant Services, Allegheny General Hospital, Pittsburgh, PA.
Pancreas transplantation (Tx) allows for the study of diabetes by examining the reversal of the disease. Previously, we observed that after pancreas Tx many patients'…2015 American Transplant Congress
The Penalty Faced By Native Americans in Kidney Transplantation: Decreased Access and Reduced Long-Term Survival
Background: Diabetes and ESRD disproportionately affect NAs (Native Americans), yet waitlisted NAs have lower rates of kidney transplantation than other racial/ethnic groups and worse longer…
American Transplant Congress abstracts