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American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    Donor Microbiota and Its Contribution for the Development of Primary Graft Dysfunction Following Human Lung Transplantation

    Z. Xu,1 R. Schuessler,1 N. Steward,1 R. Hachem,2 E. Trulock,2 A. Patterson,1 D. Kreisel,1 T. Mohanakumar.1

    1Surgery, Washington Univ Sch of Med, St. Louis, MO; 2Medicine, Washington Univ Sch of Med, St. Louis, MO.

    Background: The microbiome of the donor lung will be imported to the recipient, and its role in allograft immunity remains speculative. The aims of this…
  • 2015 American Transplant Congress

    Respiratory Infections Following Lung Transplantation Leads to De Novo Development of Antibodies to Both Donor HLA and Lung Associated Self-Antigens and Increases the Risk for Bronchiolitis Obliterans Syndrome

    K. George,1 M. Gunasekaran,1 M. Sharma,1 F. Zhou,1 A. Limaye,3 R. Hachem,2 T. Mohanakumar.1

    1Surgery, Washington Univ, St. Louis, MO; 2Medicine, Washington Univ, St. Louis, MO; 3Medicine, Univ Washington, Seattle, WA.

    Background: It is accepted that lower respiratory tract infections (LRI) post lung transplantation (LTx) are a risk factor for the development of Bronchiolitis Obliterans Syndrome…
  • 2015 American Transplant Congress

    The Impact of Alemtuzumab and Basiliximab Induction On Patient and Graft Survival in Single Lung Transplant Recipients

    Y. Furuya,1 S. Jayarajan,2 S. Taghavi,2 V. Ambur,2 F. Cordova,3 N. Patel,3 Y. Toyoda.4

    1Internal Medicine, Temple University Hospital, Philadelphia, PA; 2Surgery, Temple University Hospital, Philadelphia, PA; 3Pulmonary & Critical Care, Temple University Hospital, Philadelphia, PA; 4Cardiothoracic Surgery, Temple University Hospital, Philadelphia, PA.

    PurposeTo evaluate the impact of alemtuzumab, basiliximab and no induction therapy on patient survival and chronic rejection.Methods3242 adult single lung transplantation from 2006 to 2013…
  • 2015 American Transplant Congress

    Lung Transplant Patients With Elevated Baseline Pulmonary Arterial Pressures Are More Likely to Recover from Post-Transplant Acute Kidney Injury

    B. Stephany,1 E. Wehbe,2 M. Budev.3

    1Nephrology & Hypertension, Cleveland Clinic, Cleveland, OH; 2Nephrology, Wichita, KS; 3Pulmonary, Allergy & Critical Care, Cleveland Clinic, Cleveland, OH.

    Purpose: Elevated pre-operative pulmonary arterial pressures predict acute kidney injury (AKI) after lung transplant. It is unknown if the elevated pulmonary pressures predict recovery from…
  • 2015 American Transplant Congress

    Acute Kidney Injury After Lung Transplantation – Incidence, Risk Factors and Mechanisms

    F. Gueler,1 G. Warnecke,5 M. Peperhove,2 M.-S. Jang,1 C. Schroeder,3 S. Tewes,2 B. Wiese,6 C. Fegbeutel,5 R. Lichtinghagen,7 B. Jüttner,8 F. Wacker,2 D. Hartung,2 B. Akerstrom,4 M. Gram,4 H. Haller,1 A. Haverich,9 K. Hueper.2

    1Nephrology, Hannover Medical School, Hannover, Germany; 2Radiology, Hannover Medical School, Hannover, Germany; 3Proteomics, German Research Cancer Center, Heidelberg, Germany; 4Physiology, Lund University, Lund, Sweden; 5Thoracic and Cardiac Surgery, Hannover Medical School, Hannover, Germany; 6Medical Statistics, Hannover Medical School, Hannover, Germany; 7Laboratory Medicine, Hannover Medical School, Hannover, Germany; 8Anaesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany; 9Cardiothoracic, Transplant and Vascular Surgery, Hannover Medical School, Hannover, Germany.

    Background: Acute kidney injury (AKI) is a frequent and severe complication after solid organ transplantation. In a retrospective analysis and afterwards in a prospective clinical…
  • 2015 American Transplant Congress

    Lung Transplantation from Donors With Kidney Disease

    A. Ganapathi, B. Gulack, A. Castleberry, R. Davis, L. Snyder, M. Hartwig.

    Duke University Medical Center, Durham, NC.

    Background:Various donor characteristics are associated with decreased survival following single (SLT) or bilateral (BLT) lung transplantation. No current studies exist regarding use of lungs from…
  • 2015 American Transplant Congress

    Pre-Existing Coronary Artery Disease in Lung Transplantat Recipients: Does It Impact Outcomes?

    S. Khandhar,1 L. Tefera,2 E. Volz,2 F. Selzer,3 R. Kormos,2 C. Bermudez.2

    1Heart and Vascular Institute at Penn-Presbyterian Medical Center, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA; 2Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA; 3Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Womens Hospital, Boston, MA.

    INTRODUCTION:In patients undergoing lung transplantation (LTx), the impact of pre-existing coronary artery disease (CAD) on long-term outcomes is not well understood. This study examines the…
  • 2015 American Transplant Congress

    High Atherosclerotic Burden in Pediatric Lung Transplant Recipients

    A. Melk,1 D. Thurn-Valsassina,1 N. Schwerk,2 F. Brinkmann,2 C. Mueller.2

    1Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany; 2Department of Pediatric Pneumology and Neonatology, Hannover Medical School, Hannover, Germany.

    Purpose: Pediatric lung transplant patients have been reported to have an increased incidence of hypertension. This incidence might be caused by the treatment with calcineurin…
  • 2015 American Transplant Congress

    Lung Biopsy Findings in Pediatric Lung Transplant Patients With Restrictive Physiology

    J. Blatter,1 F. White,2 A. Faro,1 P. Michelson,1 U. Boston,3 P. Eghtesady,3 S. Sweet.1

    1Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO; 2Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO; 3Department of Cardiothoracic Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO.

    Background: Long-term survival in pediatric lung transplantation is limited by bronchiolitis obliterans (BO), but varieties of chronic lung allograft dysfunction (CLAD) are poorly understood. Restrictive…
  • 2015 American Transplant Congress

    Epidemiologic Change in Pulmonary Hypertension Patients Referred for Lung Transplantation Post Lung Allocation Score Implementation

    R. Loyaga-Rendon,1 B. Shelton,1 R. Reed,1 J. Tallaj,1 E. Diaz-Guzman,1 G. Heresi,2 J. Locke.1

    1Comprehensive Transplant Institute, University of Alabama at Birmingham, Birmingham, AL; 2Pulmonary Medicine, Cleveland Clinic Foundation, Cleveland, OH.

    Introduction: The lung allocation score (LAS) was designed and implemented in May 2005 to account for various measures of a candidate's health in an attempt…
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