ATC Abstracts

American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    Inflammation in Regions of Tubular Atrophy (IATR) Predicts Adverse Graft Outcome in Patients With Late Graft Dysfunction: A Multicenter Study

    J. Grande,1 R. Leduc,3 A. Matas.2

    1Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN; 2Surgery, University of Minnesota, Minneapolis, MN; 3Biostatistics, University of Minnesota, Minneapolis, MN.

    Purpose: Inflammation in regions of tubular atrophy (IATR) is a risk factor for late graft loss. However, IATR is associated with inflammation in non-atrophic regions…
  • 2015 American Transplant Congress

    Six-Month Urinary CCL2 Levels Predict Long-Term Renal Allograft Outcome

    J. Ho,1 D. Rush,1 A. Gao,1 H. Hopfer,2 C. Wiebe,1 P. Nickerson,1 S. Schaub,2 P. Hirt-Minkowski.2

    1Internal Medicine, Nephrology, University of Manitoba, Winnipeg, MB, Canada; 2Transplantation Immunology & Nephrology, University Hospital, Basel, Basel, Switzerland.

    Graft loss is a major cause of morbidity and mortality. We have shown that 6-month urine CCL2 is an independent predictor for death-censored graft loss.…
  • 2015 American Transplant Congress

    MDRD4 Equation Is Better Than CKD-EPI, Cockroft-Gault and Nankivell Equations to Estimate Glomerular Filtration Rate in Renal Transplantation

    E. David-Neto,1 A. Triboni,1 F. Ramos,1 F. Agena,1 F. Lemos,1 M. Sapienza,2 W. Nahas.1

    1Renal Transplantation Service, Hospital das Clínicas - University of Sao Paulo School of Medicine, Sao Paulo, Brazil; 2Nuclear Medicine Institute, Hospital das Clínicas - University of Sao Paulo School of Medicine, Sao Paulo, Brazil.

    To evaluate which estimated GFR (eGFR) equation is the most appropriate to in kidney transplanted (KTx) recipients, we obtained data from all plasma EDTA-Cr51 clearances…
  • 2015 American Transplant Congress

    MYH9 Polymorphic Variants and Chronic Lesions in Transplanted Kidney Biopsy

    J. Pazik,1 M. Oldak,2 Z. Lewandowski,3 D. Ozieblo,4 K. Michalska,5 A. Perkowska Ptasińska,1 A. Sadowska,1 M. Nowaczyk,5 J. Malejczyk,4 M. Durlik.1

    1Department of Nephrology and Transplantation Medicine, Medical University of Warsaw, Warsaw, Poland; 2Institute of Physiology and Pathology of Hearing, Warsaw, Poland; 3Department of Epidemiology, Medical University of Warsaw, Warsaw, Poland; 4Department of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland; 5Department of Clinical Immunology, Medical University of Warsaw, Warsaw, Poland.

    MYH9 encoding a non-muscle myosin heavy chain IIA is expressed in podocytes, mesangial, tubular, capillary endothelial cells and vascular wall. Intronic variants of MYH9 associate…
  • 2015 American Transplant Congress

    High Within-Patient Variability in Tacrolimus Levels Is a Predictor of Late Rejection in Young Adult Kidney Transplant Recipients

    J. van der Net, P. Harden.

    Oxford Transplant Centre / Kidney Unit, Oxford University Hospitals NHS Trust, Oxford, United Kingdom.

    Introduction: Non-adherence is an important risk factor for late rejection (rejection > 3 months post-transplant) and is the main reason why 17-29 year old kidney…
  • 2015 American Transplant Congress

    Increased Late Graft Loss in Kidney Recipients With Serum Sickness Disease Following Anti-Thymocyte Globulin Induction: Relation With an Anti-Neu5Gc Response

    A. Salama,1,2 G. Couvrat-Desvergnes,1 M. Lorent,1,3 G. Evanno,1 L. Le Berre,1 P. Hruba,4 P. Vesely,5 P. Guerif,1 A. Nicot,1 J.-M. Bach,6 Y. Foucher,1,3 S. Brouard,1 S. Castagnet,7 O. Viklicky,4 M. Giral,1 J. Harb,1 S. Jean-Paul.1

    1INSERM UMR 1064, ITUN, CHU de Nantes, Nantes University, Nantes, France; 2Société d'Accélération du Transfert de Technologies Ouest Valorisation, Rennes, France; 3EA 4275 SPHERE, Biostatistics, Clinical Research and Pharmaco-Epidemiology, Nantes, France; 4Transplant Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; 5Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic; 6IECM, EA4644 University/ONIRIS USC1383 INRA, ONIRIS, Nantes, France; 7EFS Pays de la Loire, Nantes, France.

    Anti-thymocyte globulins (ATG) are rabbit IgGs against human T cells widely used as induction treatment of kidney recipients. ATG can induce immune-complex diseases including Serum…
  • 2015 American Transplant Congress

    Comparison of Markers of Inflammation Between Dialysis Patients With and Without Failed Kidney Allograft

    R. Villca-Gonzales, R. Vazquez-Apodaca, D. Hernandez-Ramirez, L. Llorente-Peters, J. Alberu, L. Morales-Buenrostro.

    Nephrology and Transplantation, National Institute of Medical Sciences and Nutrition Salvador Zubiran, Mexico City, DF, Mexico.

    BACKGROUND: The rates of morbidity and mortality in patients with a failed kidney transplant are higher than dialysis patients who had never been transplanted. The…
  • 2015 American Transplant Congress

    Post-Kidney Allograft Nephrectomy Anti-HLA Immunization Is Not Due to a Release of Anti-HLA Antibodies from the Failed Kidney

    D. Milongo,1,3 N. Congy-Jolivet,2,3,4 A. Del Bello,1,3 F. Sallusto,5 C. Guilbeau-Frugier,6 L. Rostaing,1,3 N. Kamar.1,3

    1Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France; 2Laboratoire d'Immunologie, CHU de Toulouse, Toulouse, France; 3Université Toulouse III Paul-Sabatier, Toulouse, France; 4Laboratoire d'Immunogénétique Moléculaire, EA 3034, Université Toulouse III Paul-Sabatier, Toulouse, France; 5Department of Urology, CHU Rangueil, Toulouse, France; 6Department of Histopathology, CHU Rangueil, Toulouse, France.

    Background and aims: The reasons for the increased incidence of de novo anti-HLA donor specific antibodies (DSAs) that is observed after kidney allograft nephrectomy (NTx)…
  • 2015 American Transplant Congress

    100 Protocol Renal Allograft Biopsies at 10 Years: First Look at the Tacrolimus Era

    M. Stegall,1 W. Park,1 F. Cosio,2 L. Cornell.3

    1Transplant Surgery, Mayo Clinic, Rochester, MN; 2Medicine, Mayo Clinic, Rochester, MN; 3Laboratory Medicine, Mayo Clinic, Rochester, MN.

    This study examined late renal allograft injury in the Tacrolimus era in 10-yr protocol biopsies (Bx).Methods One hundred 10-yr protocol allograft bx were assessed using…
  • 2015 American Transplant Congress

    Proteinuria as Non-Invasive Marker for Renal Allograft Histology and Survival: A Population-Based Study

    M. Naesens, E. Lerut, M.-P. Emonds, D. Kuypers.

    University Hospitals Leuven, Leuven, Belgium.

    Background:Proteinuria is routinely measured for assessment of renal allograft status, but its diagnostic value for transplant pathology and herewith-related prognostic value remain unclear.Methods:We included 1518…
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