Abstracts Archive - Page 1421 of 1683 - ATC Abstracts

2015 American Transplant Congress
Living and Dead Mesenchymal Stem Cells Induce an Immunosuppressive Response in an Experimental Sepsis Model
F. Luk,¹ M. Roemeling-van Rhijn,¹ S. de Witte,¹ S. Korevaar,¹ R. de Bruin,² M. Betjes,¹ C. Baan,¹ M. Hoogduijn.¹
¹Nephrology and Transplantation, Dept. of Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands; ²Transplant Surgery, Dept. of Surgery, Erasmus Medical Center, Rotterdam, Netherlands.
There is evolving interest in the use of mesenchymal stem cells (MSC) as a cell therapeutic agent after solid organ transplantation. The nature of the…
2015 American Transplant Congress
Proteasome Inhibition by Bortezomib Prevents Early Graft Failure After Pancreatic Islet Transplantation
H. Ono,¹ Y. Asahi,¹ T. Yoshida,¹ Y. Koshizuka,¹ M. Watanabe,¹ U. Tomaru,² S. Emoto,¹ M. Fukai,³ A. Taketomi,¹ S. Todo,⁴ K. Yamashita.³
¹Gastroenterological Surgery1, Hokkaido University Graduate School of Medicine, Sapporo, Japan; ²Department of Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan; ³Department of Transplant Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan; ⁴St Mary's Hospital, Kurume, Japan.
Background: Islet graft loss caused by injurious inflammatory and innate immune responses, is a major obstacle in pancreatic islet transplantation (PIT). In this pathophysiology, the…
2015 American Transplant Congress
Cardiosphere-Derived Cells from Cadaver Can Improve Heart Function in a Model of Non-Ischaemic Dilated Cardiomyopathy
J. Wu,^1,2 Y. Sun,^1,2 M. Tan,³ D. Chi,^1,2 M. Zhang,^1,2 K. Kang,⁴ X. Jin,⁵ B. Yu.^1,2
¹Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China; ²Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China; ³Cardiology, The First Hospital of Fangshan District, Beijing, China; ⁴Cardiovascular Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China; ⁵Thoracic Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, China.
Objectives: Cardiosphere-derived cells (CDCs) are mainly obtained through myocardial biopsy, and could improve cardiac function and attenuate remodeling in myocardial infarction. In this study, we…
2015 American Transplant Congress
Mesenchymal Stem Cells Prevent Cold Ischemia-Reperfusion Injury in Lung Transplants
H. Wang,^1,2 W. Tian,¹ Y. Liu,³ X. Dai,¹ G. Li,³ T. Liu,^1,2 Z. Zhang,^1,2 C. Du.⁴
¹Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China; ²Tianjin General Surgery Institute, Tianjin, China; ³Department of Biology, Tianjin Medical University, Tianjin, China; ⁴Department of Urologic Sciences, The University of British Columbia, Vancouver, BC, Canada.
Background: Cold ischemia-reperfusion injury (IRI) is a major cause of graft failure in lung transplantation. Despite therapeutic benefits of mesenchymal stem cells (MSCs) in attenuating…
2015 American Transplant Congress
Orthotopic Transplantation of a Tissue Engineered Skin Graft in Athymic Mice
N. Nayakawde, P. Patil, K. Methe, M. Olausson.
Surgery, Gothenburg University, Gothenburg, Vastra Gotaland, Sweden.
Background: Tissue engineered (TE) skin offers promising alternative treatment in wound healing of acute and chronic skin injuries. Limited autografts from donor skin and risks…
2015 American Transplant Congress
MiR-26a Regulates Mouse Hepatocyte Proliferation By Directly Targeting Their 3′ Untranslated Region of CCNE2/CCND2
J. Zhou, X. Yuan, W. Ju, X. Jiao, X. Wang, M. Han, D. Wang, X. Zhu, X. He.
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Objectives: The deficiency of liver regeneration needs to be addressed in the fields of liver surgery, split liver transplantation and living donor liver transplantation. Researches…
2015 American Transplant Congress
Ex Vivo Stem Cell-Mediated Regeneration of Ischemically Damaged Renal Allografts
L. Brasile, N. Henry, A. Meyer, B. Stubenitsky.
BREONICS, Inc., Watervliet, NY.
This project attempted to accelerate repair of ischemically damaged human kidney allografts using Exsanguinous Metabolic Support (EMS) technology that is warm (32C) and acellular. While…
2015 American Transplant Congress
Marrow Mesenchymal Stem Cells Attenuate Immune Rejection in Murine Lung Allograft
X. Zhang,¹ Y. Gong,² K. Jiang,² C. Wang,² T. Xia,² J. Li,² J. Wang,² J. Nie.²
¹Department of Integrative Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China; ²Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China.
Objectives:The inherent immunosuppressive properties and low immunogenicity of mesenchymal stems cells (MSCs) suggested their therapeutic potential in transplantation. In this study we investigated if systematic…
2015 American Transplant Congress
Creation of a Functional Bio-Artificial Intestinal Segment in Rats
T. Corsello, G. Damiano, M. Tuveri, M. Montalbano, C. Rastellini, L. Cicalese.
Surgery, UTMB, Galveston, TX.
Short bowel syndrome is caused by reduced intestinal length and insufficient absorption. TPN may improve life expectancy, but is potentially associated with severe complications and…
2015 American Transplant Congress
Lifor Organ Preservation Solution Protects Pulmonary Microvasculature in a Rat Model of Ex Vivo Lung Perfusion and Transplantation
T. Okamoto,^1,3 A. Yasuda,^1,2 D. Mathisen,^1,3 H. Ott.^1,3
¹Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA; ²Department of Anesthesiology, Massachuetts General Hospital, Boston, MA; ³Department of Surgery, Massachuetts General Hospital, Boston, MA.
A. Ex Vivo Lung Perfusion (EVLP) has emerged as an innovative method for lung preservation. Microvascular dysfunction and breakdown of endothelial barrier during EVLP are…