2015 American Transplant Congress
Non-Cytoreductive Immunosuppression Prevents Rejection of Vascularized Composite Allografts
[Background] Reconstructive transplantation represents a valid therapeutic option after devastating tissue loss such as an extremity or face. Immunosuppression-free donor-specific immunological tolerance has been successfully…2015 American Transplant Congress
Altered Intestinal Microbiome as a Potential Biomarker for Failed Immune-Regulation in Autoimmune Type 1 Diabetes Mellitus
Purpose: Beta-cell destruction results due to a failure of immune-regulation in type 1 diabetes (T1D). We investigated alterations in the intestinal microbiome composition as a…2015 American Transplant Congress
Targeted Rapamycin Nanotherapy Dampens Memory T Cell Function
Memory T cells (Tm) are difficult to control post-transplantation and account for early rejection episodes. Additionally, therapies exerting local immunosuppression by targeting an allograft, while…2015 American Transplant Congress
Combined Bone Marrow Plus Liver Transplantation in Cynomolgus Monkeys
Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY.
IntroductionCombined kidney/bone marrow transplantation (CKBMT) induces tolerance in both primates and humans. Since liver is thought to be more tolerogenic than kidney, we hypothesized that…2015 American Transplant Congress
Differential Expression and Function of ASC and Nlrp3 Inflammasome Adaptors in Hematopoietic Stem Cells (HSCs)
Medicine, University of California San Diego, San Diego, CA.
HSCs are activated by pattern recognition receptors (PRRs), which might provide novel targets for improved engraftment. How PRRs affect HSC engraftment after BM transplantation is…2015 American Transplant Congress
Relative In Vitro Immunoregulatory Effects of Everolimus, Sirolimus, Tacrolimus, Mycophenolic Acid and Drug Combinations
Everolimus (EVL) is a modified form of the mTOR-inhibitor Sirolimus (SRL) and is used clinically in combination with Mycophenolate (MMF) and/or Tacrolimus (TAC). The purpose…2015 American Transplant Congress
Cell Type of the Tolerizing Inoculum Plays a Role in the Formation of of Molecular Chimerism in Murine Neonatal Tolerance
Background: Heart transplantation is a lifesaving measure for many infants with severe congenital heart diseases. The acceptance of cardiac allografts without immunosuppression, or operational tolerance,…2015 American Transplant Congress
Hybrid Ostomy – New Technique in Intestinal Transplantation
Miami Transplant Institute, University of Miami Miller School of Medicine, Miami, FL.
Introduction: Many experimental non-invasive methods have been tested to assess the intestinal graft, but none of them proved to be reliable. Biopsy of the intestine…2015 American Transplant Congress
Long-Term Persistence of Innate Lymphoid Cells in the Gut After Intestinal Transplantation
Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY.
Introduction: Little is known about innate lymphoid cell (ILC) populations in the human gut, and the turnover of these cells and their subsets after transplantation…2015 American Transplant Congress
Pre-Operative Assessment of Body Composition in Adult Multivisceral Transplant Candidates
Department of Surgery, Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA.
Body Mass Index is commonly used, but is likely to be an inexact measurement of nutritional status. For this reason, we examined whether body composition…
American Transplant Congress abstracts