Abstracts Archive - Page 1412 of 1683 - ATC Abstracts

2015 American Transplant Congress
Dual PI3K-mTOR Inhibition on Human T Cell Activation, Proliferation, and Differentiation: The First Step in the Development of New Immunosuppressants
V. Vilchez,¹ A. Castellanos,¹ D. Butterfield,³ M. Mitov,³ C. Hoopes,¹ F. Marti,² R. Gedaly.¹
¹Department of Surgery - Transplant Section, University of Kentucky, Lexington, KY; ²Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY; ³Free Radical Biology in Cancer Shared Resource Facility, University of Kentucky, Lexington, KY.
Background: Regulatory T lymphocytes (Tregs) contribute to transplant tolerance. We have demonstrated that the inhibition of PI3K-mTOR pathway has a major role in the differentiation…
2015 American Transplant Congress
Immunomodulation of Human T Cells by a Novel RALG Preparation With Higher Specificity Toward Activating T Cells
K. Samy, H. Xu, A. Kirk.
Surgery, Duke University Medical Center, Durham, NC.
Current induction therapy using thymoglobulin (ATG) results in nonspecific T cell depletion. We have generated a polyclonal rabbit anti-human leukocyte globulin (RALG) by immunizing rabbits…
2015 American Transplant Congress
Effects of Mast Cell Stabilization on the Development of Aspiration-Induced Fibrosis in a Rat Model
E. Sapmaz, Z. Sun, J.-C. Chang, N. Sanders, S. Bell, M. Everett, Z. Holzknecht, W. Parker, R. Davis, S. Lin.
Surgery, Duke University Medical Center, Durham, NC.
Gastric fluid aspiration affects a great number of lung transplant recipients, both before and after the transplant, and can contribute significantly to morbidity and mortality.…
2015 American Transplant Congress
Aging Enhances Immunosuppressives Capacities of Tacrolimus By Functional Changes of CD4+ T-Cells
F. Krenzien,¹ M. Quante,¹ A. ElKhal,¹ H. Uehara,¹ R. Abdi,² B. Slegtenhorst,¹ H. Biefer,¹ S. Tullius.¹
¹Transplant Surgery Research Laboratory and Division of Transplant Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; ²Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Immunosenescence has broad consequences on alloimmunity and immunosuppression in the elderly may require age-adaptation. Here, we investigated the influence of aging on the effectivity of…
2015 American Transplant Congress
Single Infusion of Donor-Type Splenocytes Treated With Extracorporeal Photopheresis Prior to Transplantation Significantly Prolongs Cardiac Allograft Survival in Mice
J. Schneiderman,¹ J. Ye,² X. Yeap,² M. Caralt,² J.-J. Wang,² Z. Zhang.²
¹Ped Hematology/Oncology/Stem Cell Transplant, Feinberg School of Medicine Northwestern University, Chicago, IL; ²Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Background: Extracorporeal Photopheresis (ECP) is an immune therapy in which blood leukocytes are treated with 8-methoxypsoralen (8-MOP), exposed to UV-A light, and re-infused. This study…
2015 American Transplant Congress
Heart En Bloc Thymus Transplantation Permits Long-Term, Acute Rejection-Free Cardiac Allograft Survival in Nonhuman Primates (NHPs)
M. Tonsho,¹ P. Spencer,¹ T. Millington,¹ A. Muniappan,¹ A. Tena,² R. Smith,³ R. Colvin,³ J. Allan,^1,2 J. Madsen.^1,2,4
¹MGH Transplant Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ²Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ³Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ⁴Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
BACKGROUNDThe role of vascularized thymus on tolerance induction has been well studied in swine recipients of kidney allografts, but not in NHP recipients of heart…
2015 American Transplant Congress
Human CD8⁺TCR^– Facilitating Cells Enhance HSC Engraftment In Vivo and Promote HSC Survival In Vitro
Y. Huang,¹ M. Elliott,¹ E. Yolcu,¹ T. Miller,¹ L. Bozulic,² Y. Wen,¹ H. Xu,¹ S. Ildstad.^1,2
¹Institute for Cellular Therapeutics, University of Louisville, Louisville, KY; ²Regenerex, LLC, Louisville, KY.
CD8+/TCR- facilitating cells (FC) in mouse BM significantly enhance engraftment of hematopoietic stem cells (HSC) in syngeneic and allogeneic recipients. Human FC phenotype and mechanism…
2015 American Transplant Congress
Neonatal Tolerance: Donor and Host Cells Fuse in Livers of Newborn Mice Injected With F1-Bone Marrow/Spleen Cells
R. Bascom, K. Tao, S. Tollenaar, L. West.
University of Alberta, Edmonton, Canada.
Purpose: Multiple liver cell-types induce immunological tolerance. Indeed liver allografts are often spontaneously accepted in humans and mice. The role of host liver in the…
2015 American Transplant Congress
Effects of Heart and Lung Co-Transplantation Across a Full MHC Barrier in Miniature Swine
M. Madariaga, P. Spencer, S. Michel, G. La Muraglia II, M. O'Neil, E. Mannon, C. Leblang, I. Rosales, R. Colvin, D. Sachs, J. Allan, J. Madsen.
Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Background: We have previously shown that tolerance of heart allografts across a full MHC barrier can be induced in miniature swine after a 12-day course…
2015 American Transplant Congress
Human Adipose Derived Mesenchymal Stem Cells Enhance Bone Marrow Engraftment and Induce Immunological Tolerance
R. Saidi,² B. Rajeshkumar,¹ P. Agrawal,¹ M. Rashighi.¹
¹UMASS, Worcester; ²Alpert Medical School of Brown University, Providence.
Organ transplantation currently requires long-term immunosuppression. This is associated with multiple complications including infection, malignancy and other toxicities. Immunologic tolerance is considered the optimal solution…