ATC Abstracts

American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    Basiliximab Induction With Delayed Tacrolimus Initiation up to 14 Days Post Liver Transplantation Maintains Excellent Clinical Outcomes While Preserving Renal Function

    J. Werth, W. Ally, D. Maluf, S. Pelletier.

    University of Virginia Health System, Charlottesville, VA.

    Background: Calcineurin inhibitors are frequently delayed to allow for recovery of renal function after transplantation; however, there is a paucity of literature supporting a delay…
  • 2015 American Transplant Congress

    Hepatic T Cells Derived from Normothemic Machine Perfused Grafts Contained More Regulatory T Cells and Fewer Proinflammatory Cytokines Producing T Cells Than Those from Cold Storage Grafts

    X. Huang, R. Ravikumar, C. Coussios, P. Srinivasan, N. Heaton, P. Friend, W. Jassem, Y. Ma.

    1Institute of Liver Studies, King's College London School of Medicine at King's College, London, United Kingdom; Nuffield Department of Surgical Sciences, Oxford University, Oxford, United Kingdom.

    Background & aim:In liver transplantation, ischemia reperfusion (I/R) injury is associated with an inflammatory response affecting graft and patient outcomes. Ex-vivo normothermic machine perfusion (NMP)…
  • 2015 American Transplant Congress

    Clinical Utility of Allospecific CD154+T-Cells in Children With Liver Or Intestine Transplantation (LTx, ITx)

    K. Soltys, G. Bond, G. Mazariegos, C. Ashokkumar, K. Dirling, L. O'Toole, P. Kachmar, T. Hartle, D. Martin, C. Trautz, R. Sindhi.

    Hillman Center for Pediatric Transplantation, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.

    Background: Allospecific CD154+T-cytotoxic memory (CD154+TcM) have completed investigational evaluation as predictors of acute cellular rejection in children with LTx or ITx.Purpose: To evaluate CD154+TcM** as…
  • 2015 American Transplant Congress

    Pharmacist-Led Renal-Sparing Conversion to Everolimus After Liver Transplantation

    T. Horwedel,1 L. Bowman,1 W. Chapman,2 J. Hagopian.1

    1Barnes-Jewish Hospital, St. Louis, MO; 2Washington University in St. Louis, St. Louis, MO.

    Purpose: Preservation of renal function following orthotopic liver transplantation (OLT) through calcineurin inhibitor (CNI)-minimization is an established clinical objective. The use of everolimus (EVR) to…
  • 2015 American Transplant Congress

    Everolimus-Based Immunosuppression Is Associated With a Reduced Risk of New-Onset Malignancies After Liver Transplantation

    P. De Simone,1 P. Carrai,1 L. Coletti,1 D. Ghinolfi,1 D. Campani,2 F. Filipponi.1

    1Hepatobiliary Surgery and Liver Transplantation, University of Pisa Medical School Hospital, Pisa, Italy; 2Pathology, University of Pisa Medical School Hospital, Pisa, Italy.

    Background and aim: The inhibitor of the mammalian target of rapamycin (mTOR) everolimus (EVR) has shown anti-proliferative effects in experimental and clinical models. We investigated…
  • 2015 American Transplant Congress

    Plasmapharesis, Intravenous Immunoglobulin and Rituximab Successfully Treat Recurrent Progressive Familial Intrahepatic Cholestasis Type 2 (PFIC-2) After Liver Transplantation

    H. Elsiesy,1 F. Abaalkhail,1 W. Alhamoudi,1,2 H. Alhussaini,3 M. Alsebayel,1 D. Broring,1 M. Shagrani.1

    1Liver Trasplantation, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia; 2Gastroenterology, King Saud University, Riyadh, Saudi Arabia; 3Pathology, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.

    Background:Allo-immune mediated BSEP dysfunction may occur after liver transplantation in PFIC2 patients leading to a PFIC2 like phenotype. The IgG antibodies are reactive toward a…
  • 2015 American Transplant Congress

    Safety and Efficacy of Early Everolimus in De Novo Orthotopic Liver Transplantation

    M. Gastaca,1 I. Bilbao,2 M. Jimenez,3 J. Bustamente,1 C. Dopazo,2 R. Gonzalez,3 R. Charco,2 J. Santoyo,4 J. Ortiz de Urbina.1

    1Liver Transplantation Unit, Cruces University Hospital. University of the Basque Country, Bilbao, Vizcaya, Spain; 2Hepatobiliopancreatic Surgery and Liver Transplant Unit, Hospital Universitario Vall d´Hebron, Barcelona, Spain; 3Unidad de Hepatología-Trasplante Hepático, Hospital Regional Universitario de Malaga, Malaga, Spain; 4Unidad de Cirugía Hepatobiliar-Trasplante Hepático, Hospital Regional Universitario de Malaga, Malaga, Spain.

    Purpose: To study the safety and efficacy of immunosuppression with Everolimus (EVL) within the first month after orthotopic liver transplantation.Patients and methods: Recipients who had…
  • 2015 American Transplant Congress

    Does Smoking Lead to Increased Rates of Acute Cellular Rejection in Liver Transplant Recipients?

    B. Rao,1 D. Montezuma-Calvo,2 K. Tosch,2 S.-M. Jafri.2

    1Internal Medicine, Henry Ford Hospital, Detroit, MI; 2Gastroenterology and Hepatology, Henry Ford Hospital, Detroit, MI.

    Introduction: Prior studies of liver transplant recipients who smoke have shown associations between mortality and adverse outcomes. We investigated if smoking status at the time…
  • 2015 American Transplant Congress

    De Novo Once-Daily Tacrolimus in Liver Transplantation: Long-Term Outcomes of a Single Center Cohort of 150 Patients

    M. Gastaca, A. Valdivieso, J. Bustamante, P. Ruiz, J. Fernandez, A. Ventoso, M. Testillano, I. Palomares, P. Salvador, M. Prieto, A. Matarranz, M. Suarez, J. Ortiz de Urbina.

    Liver Transplantation Unit, Cruces University Hospital. University of the Basque Country, Bilbao, Vizcaya, Spain.

    Purpose: To describe the long-term safety and efficacy profile of de novo once-daily tacrolimus (Tac QD) in orthotopic liver transplantation (OLT)Patients and methods: A retrospective…
  • 2015 American Transplant Congress

    The Best Regimen With Rituximab for ABO-Incompatible Living Donor Liver Transplantation

    H. Egawa,1 K. Umeshita,2 S. Uemoto.3

    1Surgery, Tokyo Women's Medical University, Tokyo, Japan; 2Osaka University, Suita, Japan; 3Kyoto University, Kyoto, Japan.

    Rituximab made a great progress on outcomes of ABO-incompatible living donor liver transplantation (ABO-I LDLT). Although Japanese multicenter study group published efficacy and safety of…
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