2015 American Transplant Congress
DQB1 Epitope Matching Predicts the Development of De Novo DSA and Antibody Mediated Rejection
HLA DQ antibodies are the commonest de novo [DN] DSA specificity seen post renal transplantation. Their presence is associated with antibody mediated injury and allograft…2015 American Transplant Congress
Kidney Transplantation (KTx) With Positive Crossmatch (XM) but No Donor Specific Antibody (DSA)
MedStar Georgetown Transplant Institute, Washington, DC.
Purpose: Prior to KTx, a XM is performed between the intended recipient and donor. This XM can be positive despite no DSA. It can be…2015 American Transplant Congress
Intimal Arteritis Associated With Subsequent Graft Dysfunction in ABO-Incompatible Kidney Transplantation
Purpose: The diagnosis of acute antibody-mediated rejection (ABMR) is according to following all three evidences: 1) histologic evidence , 2) evidence of interaction with vascular…2015 American Transplant Congress
Impact of HLA Antibody Monitoring After Kidney Transplantation
The impact of donor specific antibodies (DSA) and optimal therapeutic intervention for DSA in kidney transplant (KT) recipients has been reported with variable results. We…2015 American Transplant Congress
Number of Antigen Targets: A Key Parameter for Accurate Flow Cytometry Crossmatch Interpretation of Weak DSA
BACKGROUND: Flow cytometry crossmatch (FCXM) results are used to assess the safety of a transplant across pre-existing DSA. The number of targets on donor cells…2015 American Transplant Congress
Preformed Anti-HLA DP Donor Specific Antibodies Are Clinically Significant in Renal Transplantation
Renal and Transplant Medicine, Imperial Healthcare NHS Trust, London, United Kingdom.
Background: Whilst preformed [PF] anti-HLA A, B, DR and DQ donor specific antibodies [DSAbs] are associated with poorer allograft outcomes secondary to antibody mediated injury,…2015 American Transplant Congress
Mycophenolic Acid Area-Under-Curve (MPA AUC) Levels Sufficient to Prevent Donor-Specific Antibody (DSA) Formation Are Not Associated With Higher Rates of CMV/EBV/BK Viral Infections
PinnacleHealth, Harrisburg, PA.
Background: Prevention of DSA formation and antibody-mediated rejection mandates therapeutic doses of immunosuppressive agents, including MPA. We have shown that MPA AUC monitoring and dose…2015 American Transplant Congress
Bortezomib Treatment in Antibody Mediated Rejection After Kidney Transplantation
BackgroundSeveral studies demonstrated bortezomib therapy for antibody-mediated rejection (AMR) in renal transplants. However, the treatment efficacy according to target antigen or occurrence time of AMR…2015 American Transplant Congress
Angiotensin Receptor Antibody IgG1 Subclass Predicts Accelerated Graft Loss in Those Kidney Transplant Recipients Who Develop Biopsy Proven Transplant Glomerulopathy Irrespective of the Presence Or Absence of Donor Specific Anti HLA Antibodies
We assessed the presence or absence of angiotensin receptor antibodies (ATRab) in all those Kidney Transplant Patients who have had biopsy proven transplant glomerulopathy (TG)…2015 American Transplant Congress
Outcomes of Treatment of Late Antibody-Mediated Rejection in Primary Renal Transplant Recipients – A Single Center Experience
Division of Nephrology and Transplant Institute, Henry Ford Hospital, Detroit, MI.
Background: Successful reversal of early post-transplant antibody mediated rejection (AMR) is well documented, but data on the results of treatment of late AMR are lacking.…
American Transplant Congress abstracts