2015 American Transplant Congress
Are AT1R Antibodies as Dangerous as HLA-DSAs in Renal Allografts?
Angiotensin II type 1 receptor antibodies (AT1Rab) have been associated with a significantly lower graft survival and a higher risk of acute rejection after kidney…2015 American Transplant Congress
Changes in Donor Specific Antibodies (DSA) First Year After Kidney Transplant (KTX): Implications for Graft Histology and Survival
Introduction. De novo DSA post-KTx is associated with high risk of chronic antibody mediated rejection (cAMR) and reduced graft survival. DSA changes during first year…2015 American Transplant Congress
Donor Selection and Prophylactic IVIg for Induction Immunosuppression Improves Outcomes for HIV+ Kidney Transplant Recipients (HIV+ Tx)
HIV+ Tx recipients are noted to have higher rates of allorecognition through cellular and humoral mediated pathways. Since 2010, our program instituted IVIg use as…2015 American Transplant Congress
Protocol Donor Specific Antibody Monitoring After Kidney Transplantation: What Is the Utility?
De novo DSA has been shown to be a negative predictor of graft outcomes. However, the utility of routine DSA monitoring in the overall kidney…2015 American Transplant Congress
Microcirculation Inflammation in Early Surveillance Renal Biopsy in Sensitized Patients Did Not Correlate With Graft Outcome
1Renal Transplant Unit, HC - FMUSP, S Paulo, SP, Brazil; 2Lab de HLA, InCor, S Paulo, SP, Brazil.
Introduction: Microcirculation inflammation (MI) at 3-month renal biopsies and preformed donor-specific antibodies (DSA) are considered predictors of bad outcome in sensitized patients. Earlier biopsies and…2015 American Transplant Congress
Improving ABMR Diagnostics Through Advanced Anti-HLA Antibody Screening Techniques
The identification of low-level antibodies by single antigen bead methodology has brought advancements in risk evaluation of kidney transplants recipients. However, the use of the…2015 American Transplant Congress
Transplant Glomerulitis in Allograft Kidneys Is Correlated With Antibody-Mediated Rejection
Background: Antibody-mediated rejection manifests with glomerular and peritubular capillary inflammation, transplant glomerulopathy. Transplant glomerulitis is an increasingly recognized lesion in renal transplant biopsies, characterized by…2015 American Transplant Congress
Serum Creatinine Is Most Predictive of Graft Loss in Late Antibody Mediated Rejection
Comprehensive Transplant Institute, University of Alabama at Birmingham, Birmingham, AL.
Development of acute antibody mediated rejection (AMR) is associated with graft loss and can occur both early (< 3 months) and late (> 3 months)…2015 American Transplant Congress
High Prevalence of Allograft Rejection in Kidney Recipients With a Mild Increase in Serum Creatinine: Interim Report of the ANIDAR Study
The long-term prognosis of kidney transplants may be impacted by delayed diagnosis of rejection. Guidelines suggest that recipients with an increase of serum creatinine (Scr)…2015 American Transplant Congress
Correlation Between C3d-Binding De Novo Donor Specific HLA Antibodies and Rejection in Kidney Transplant Recipients
Comprehensive Transplant Center, Northwestern University, Chicago, IL.
Donor specific antibodies (DSA) directed against HLA arising de novo post-kidney transplant are a major cause of graft loss, termed antibody mediated rejection (AMR). Currently,…
American Transplant Congress abstracts