ATC Abstracts

American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    Post-Transplant Changes in Serum Creatinine and Beta-2 Microglobulin Predict Acute Tubular Necrosis in the Early Post-Transplant Period

    P. Liu,1 A. Djamali,1,2 D. Kaufman,2,1 B. Astor.1

    1Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI; 2Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.

    Purpose: To evaluate the utility of early post-transplant changes in serum creatinine (SCr) and beta-2 microglobulin (B2M) in differentiating acute tubular necrosis (ATN) and other…
  • 2015 American Transplant Congress

    Acute Kidney Injury in the Early Post Kidney Transplant Period: Frequency, Etiology and Significance

    B. Kiberd,1 S. Cimen,1 K. Tennankore.2

    1Surgery, Dalhousie University, Halifax, NS, Canada; 2Medicine, Dalhousie University, Halifax, NS, Canada.

    Acute kidney injury (AKI) post kidney transplant has not been well described using current diagnostic criteria. The frequency and etiology of AKI in the first…
  • 2015 American Transplant Congress

    Proximal Tubular Dysfunction Is Common After the First Year of Kidney Transplantation

    G. Ensergueix,1 J. Allard,1 F. Saint-Marcoux,2 B. Marin,3 S. Bodeau,2 J.-C. Aldigier,1 P. Marquet,2 M. Essig.1

    1Nephrology, Dialysis, Transplantation, University Hospital, Limoges, France; 2Pharmacology, Toxicology, University Hospital, Limoges, France; 3Epidemiology, Biostatistics, Methodology, University Hospital, Limoges, France.

    Background: After the initial period of kidney transplantation, the prevalence of proximal tubular dysfunction (PTD) and its consequences are unknown. The aim of this study…
  • 2015 American Transplant Congress

    Molecular Features of Isolated Arteriolar Hyalinosis in Renal Transplant Biopsies

    L. Kamal, P. O Broin, Y. Bao, A. Golden, E. Akalin.

    Einstein/Montefiore Transplant Program, Computational Genomics Facility, Albert Einstein College of Medicine, Bronx, NY.

    Background: Arteriolar hyalinosis (ah) is characterized by deposition of hyaline material in the vascular wall that may be caused by different insults including diabetes, hypertension…
  • 2015 American Transplant Congress

    A Clinical Signature Surrogate of Histological Lesions to Avoid Unnecessary One Year Surveillance Biopsy After Renal Transplantation

    E. Dantan, K. Renaudin, S. Brouard, A. Huneau, C. Paul, M. Giral.

    Biostatitics, Nantes University, Nantes, France; Anatomo Pathology, University Hospital, Nantes, France; Immunology, Inserm UMR1064, Nantes, France; Biostatistics, Nantes University, Nantes, France; Immunology, Inserm UMR1064, Nantes, France; Nephrology, University Hospital, Nantes, France.

    Introduction:Surveillance biopsy remains debated after renal transplantation since the histological diagnostic do not lead to clear therapeutic recommendations. The main objective for this study was…
  • 2015 American Transplant Congress

    Histologic Findings in Pre-transplant AT1Rab + ve Patients Point to an Increase in Sub-Intimal Fibrosis During Acute Rejection and in 12 mo. Protocol Renal Graft Biopsies

    A. González-Almada, J. Arreola-Guerra, E. Cuevas, M. Vilatoba, A. Contreras, A. Sanchez-Cedillo, J. Alberu, N. Uribe-Uribe.

    1Transplantation, 1aNephrology-Mineral Metabolism, 1bPathology, Inst Nal de Ciencias Medicas y Nutricion SZ, Mexico City, Distrito Federal, Mexico.

    Previous reports have described an increase in arteritis during acute rejection (AR) in angiotensin II type 1 receptor antibody (AT1Rab) positive (ve+) kidney transplant recipients…
  • 2015 American Transplant Congress

    Treatment of Subclinical Rejection Identified On Surveillance Biopsy May Prevent the Development of Chronic Alloimmune Injury

    M. Willicombe, C. Roufosse, J. Galliford, A. McLean, D. Taube.

    Imperial College Kidney and Transplant Centre, Hammersmith Hospital, London, United Kingdom.

    Surveillance biopsies [SBx] are not universally performed following renal transplantation. In patients in whom protocol biopsies are performed, how best to manage subclinical rejection [SCR]…
  • 2015 American Transplant Congress

    Differential Intragraft Gene Expression Profiles in Patients With Sterile Leukocyturia

    M. Ajaimy,1 P. O Broin,2 Y. Bao,1 J. Lindower,1 A. Golden,2 E. Akalin.1

    1Transplantation, Einstein/Montefiore Transplant Center, Bronx; 2Computational Genomics Facility, Albert/Einstein College of Medicine, Bronx.

    Objective: We aimed to investigate if sterile leukocyturia reflects increased intragraft immune activity and gene expression profiles of transplant kidney biopsies differ from patients without…
  • 2015 American Transplant Congress

    Implications of Living Kidney Donor Histology, Volume and Function on Allograft Outcome

    S. Shah,1 B. Lankowsky,2 L. Herlitz,3 A. Chiesa-Vottero,3 Z. Zaky,1 D. Goldfarb,4 S. Flechner,4 E. Poggio.1

    1Nephrology, Cleveland Clinic, Cleveland, OH; 2Case Western University SOM, Cleveland, OH; 3Pathology, Cleveland Clinic, Cleveland, OH; 4Urology, Cleveland Clinic, Cleveland, OH.

    Donor factors are determinants of donor quality and therefore graft function in deceased donation (DD). We hypothesized that analogous to DD, donor factors such as…
  • 2015 American Transplant Congress

    hTERT, BICD1 and Chromosome 18 Polymorphisms Affecting Telomere Length Are Associated With Kidney Transplantation Outcome

    L. Domanski,1 K. Kloda,1 K. Safranow,2 A. Drozd,3 K. Ciechanowski,1 A. Ciechanowicz.4

    1Clinical Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University in Szczecin, Szczecin, Poland; 2Department of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, Szczecin, Poland; 3Department of Biochemistry and Human Nutrition, Pomeranian Medical University in Szczecin, Szczecin, Poland; 4Department of Laboratory Diagnostics and Molecular Medicine, Pomeranian Medical University in Szczecin, Szczecin, Poland.

    Telomere length (TL) has been analyzed in regard to cell senescence and ageing of animals and humans, including age-related diseases. There have been also attempts…
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