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American Transplant Congress abstracts

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  • 2022 American Transplant Congress

    The Role of Geography in Adult Heart Allocation Over the Last 5 Years

    K. Bradbrook1, R. Goff1, R. Daly2, S. Hall3

    1Research, United Network for Organ Sharing, Richmond, VA, 2Mayo Clinic, Rochester, MN, 3Baylor University Medical Center, Dallas, TX

    *Purpose: In the last 5 years two policies have impacted the role of geography in adult heart allocation including the 2018 adult heart policy which…
  • 2022 American Transplant Congress

    APN-Driven COVID-19 Monitoring Model for Kidney Transplant Patients

    J. Yoo, S. Patel, T. Clevy-Schneller, A. Desai, R. Sodhi, D. Jain, S. Akkina

    Loyola University Medical Center, Maywood, IL

    *Purpose: COVID-19 infection in kidney transplant (KT) recipients is characterized by an unpredictable course and can be life-threatening. Prompt adjustment of immunosuppression and hospitalization when…
  • 2022 American Transplant Congress

    Donor Kidney-Resident Passenger Macrophages Promote CCL8-CCR8 Mediated Early Allograft Inflammation

    A. Dangi1, I. Husain2, N. Natesh3, X. Shen3, J. Kwun4, X. Luo5

    1Medicine, Duke University Medical Center, Durham, NC, 2Duke University Medical Center, Durham, NC, 3Biomedical Engineering, Duke University, Durham, NC, 4Duke Transplant Center, Durham, NC, 5Duke University School of Medicine, Durham, NC

    *Purpose: Early intragraft infiltration of monocytes and macrophages has been associated with acute and chronic allograft rejections. Nevertheless, underlying mechanism remained poorly understood. In the…
  • 2022 American Transplant Congress

    Holes in the Safety-Net: Examining the Path to Kidney Transplantation for Liver Transplant Recipients with Persistent Kidney Dysfunction

    A. J. Erhardt, M. J. Hobeika, T. Menser, A. Saharia, O. Okidi, C. Mobley, R. McMillan, L. W. Moore, H. Podder, S. Yi, R. J. Knight, A. Gaber, R. Ghobrial

    Department of Surgery; J.C. Walter Jr. Transplant Center, Houston Methodist Hospital, Houston, TX

    *Purpose: The 2017 combined liver-kidney allocation modification provided early access to kidney transplantation (KT) for liver transplant (LT) recipients with severe post-LT kidney dysfunction. Although…
  • 2022 American Transplant Congress

    Preemptive  Therapy for Cytomegalovirus (CMV) Disease Prevention in High-Risk CMV Donor Seropositive Recipient Seronegative (D+/R-) Liver Transplant Recipients in a Real-World Setting 

    K. M. Doss1, C. Kling1, M. R. Heldman1, N. Singh2, M. Wagener3, C. E. Fisher1, A. Limaye1

    1University of Washington, Seattle, WA, 2University of Pittsburgh, PIttsburgh, PA, 3University of Pittsburgh, Pittsburgh, PA

    *Purpose:  Preemptive therapy  (PET)  has  demonstrated superiority to antiviral prophylaxis  for  prevention of  cytomegalovirus (CMV)  disease  in  CMV  donor seropositive/recipient seronegative (D+R-)  liver transplant recipients …
  • 2022 American Transplant Congress

    Socioeconomic Factors Influence Likelihood of Directed Living Donor Transplant Among Children with End-Stage Renal or Liver Disease

    D. Yoeli, S. Mathai, C. O'Neill, E. Lamberty, J. Kaar, C. Mata, A. Feldman, M. Bock, W. Jackson, M. Adams

    University of Colorado Anschutz Medical, Aurora, CO

    *Purpose: Previous studies have demonstrated that children with public insurance are less likely to receive a transplant from a directed living donor. Type of insurance…
  • 2022 American Transplant Congress

    Successful Outcome of Highly Sensitized Patients After Heart Transplantation Under RATG Regimen

    G. Esmailian, T. Singer-Englar, J. Patel, M. Kittleson, S. Kim, N. Patel, D. Chang, E. Kransdorf, F. Esmailian, J. A. Kobashigawa

    Cedars-Sinai Smidt Heart Institute, Los Angeles, CA

    *Purpose: Highly sensitized patients (panel reactive antibody [PRA] ≥50%) are known to be at risk for poor outcome after heart transplantation (HTx). In our program,…
  • 2022 American Transplant Congress

    Toll-Like Receptor-4 Inhibitor, Resatorvid, Attenuates Allogenic T Cell Activation Against Human Pancreatic Islets by Decreasing CD69 Expression

    J. Mattke1, M. Plunk1, R. R. Kane1, B. Naziruddin2

    1Baylor University, Waco, TX, 2Baylor University Medical Ctr, Dallas, TX

    *Purpose: Allogenic and autoimmune response against islets remain major obstacles to improve long term function of islet transplants. Inhibition of toll-like receptor 4 (TLR4) using…
  • 2022 American Transplant Congress

    RNA-Sequencing Analysis of Kidney Allografts Reveal Heightened NK Cell Activity in Chronic Active Antibody-Mediated Rejection

    Y. Shah, E. Varma, S. Rahim, C. Li, C. Snopkowski, C. Hughes, D. M. Dadhania, S. Salvatore, S. V. Seshan, O. Elemento, M. Suthanthiran, T. Muthukumar

    Weill Cornell Medicine, New York, NY

    *Purpose: The role of NK cells is increasingly recognized in chronic active antibody mediated rejection (caABMR) of the kidney allograft. Treatment of caABMR is challenging…
  • 2022 American Transplant Congress

    Sars-cov-2 Antibodies Transitions After Vaccination In Solid Organ Transplant Recipients: Multicenter Study In Japan

    K. Unagami1, M. Yoshikawa2, Y. Natori3, K. Omoto1, H. Ishida1, H. Date4, R. Imamura5, T. Ito4, K. Miyaji6, S. Takahara7, K. Yuzawa8, O. Satoko9, Y. Hirota10, H. Egawa1

    1Tokyo Women's Medical University, Tokyo, Japan, 2Kyoto Prefectural University of Medicine, Kyoto, Japan, 3University of Miami, Pinecrest, FL, 4Kyoto University, Kyoto, Japan, 5Dept. of Urology, Osaka Univ. Graduate School of Medicine, Suita, Japan, 6Renal Transplantation, Takatsuki General Hospital, Takatsuki, Japan, 7Kansai Medical Hospital, Toyonaka, Japan, 8Tranplantation Surgery, National Hospital Organization Mito Medical Center, Mito, Japan, 9Public Health, Osaka City University Graduate School of Medicine and Research Center for Infectious, Osaka City University Graduate School of Medicine, Osaka, Japan, 10Clinical Epidemiology Research Center, Miyama, Japan

    *Purpose: For purpose of SARS-CoV-2 infection control, vaccination was started in worldwide, however, low reactivity of antibody production after vaccination is a concern for solid…
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