Abstracts Archive - Page 139 of 1683 - ATC Abstracts

2022 American Transplant Congress
Toll-Like Receptor-4 Inhibitor, Resatorvid, Attenuates Allogenic T Cell Activation Against Human Pancreatic Islets by Decreasing CD69 Expression
J. Mattke¹, M. Plunk¹, R. R. Kane¹, B. Naziruddin²
¹Baylor University, Waco, TX, ²Baylor University Medical Ctr, Dallas, TX
*Purpose: Allogenic and autoimmune response against islets remain major obstacles to improve long term function of islet transplants. Inhibition of toll-like receptor 4 (TLR4) using…
2022 American Transplant Congress
Area Deprivation Index is Associated with Worse Patient Survival Following Adult Kidney Transplantation
J. Hendele¹, J. Perkins², J. Nichols³, A. Dick⁴
¹Division of Transplant Surgery, Department of Surgery, University of Washington, Seattle, WA, ²Clinical and Bio-Analytics Transplant Laboratory (CBATL), University of Washington, Seattle, WA, ³University of Washington School of Medicine, Seattle, WA, ⁴University of Washington School of Medicine Seattle, Seattle, WA
*Purpose: Area Deprivation Index (ADI) has been utilized as a granular measure of local socioeconomic status for nearly two decades. This study is the first…
2022 American Transplant Congress
Comparing Infection Rate Between Steroid Withdrawal and Ongoing Maintenance Among Simultaneous Pancreas-Kidney Transplant Recipients
M. McCord¹, Z. Yetmar², A. Lemke¹, K. Mara³, M. T. Seville⁴, W. Bosch⁵, P. Dean⁶, E. Beam², S. Bernard¹
¹Department of Pharmacy, Mayo Clinic, Rochester, MN, ²Division of Infectious Diseases, Mayo Clinic, Rochester, MN, ³Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, ⁴Division of Infectious Diseases, Mayo Clinic Arizona, Scottsdale, AZ, ⁵Division of Infectious Diseases, Mayo Clinic, Jacksonville, FL, ⁶Division of Transplantation Surgery, Mayo Clinic, Rochester, MN
*Purpose: Compare infection rates of simultaneous pancreas-kidney transplant (SPK) recipients who continue maintenance steroids to those with steroid withdrawal post transplant.*Methods: This study is a…
2022 American Transplant Congress
Reasons for Kidney Transplant Patients to Have Outpatient Urine Cultures in the First Year Post-Transplant: An Analysis of the USRDS
V. Hemmige¹, E. Akalin², M. Kinkhabwala³
¹Montefiore Medical Center, Bronx, NY, ²Albert Einstein College of Medicine, Montefiore Medical Ctr, Bronx, NY, ³Albert Einstein College of Medicine, Bronx, NY
*Purpose: Urine cultures are frequently sent in the first year after kidney transplant, but the reasons that testing is done post-transplant is not well understood.…
2022 American Transplant Congress
Kidney Allograft Loss After Simultaneous Liver Kidney (SLK) Transplant Before and After the New SLK Allocation Criteria Implementation
A. P. Bregman¹, S. Jackson², N. Lim¹, J. Lake¹, S. Riad¹
¹Medicine, University of Minnesota, Minneapolis, MN, ²Analytics, Mhealth-Fairview, Minneapolis, MN
*Purpose: On August 10, 2017 UNOS/OPTN implemented new allocation criteria for simultaneous liver-kidney (SLK) transplants. We sought to examine the association between the new allocation…
2022 American Transplant Congress
Targeting the Bet Family Protein Brd4 Inhibits Inflammatory Macrophages and Promotes Heart Allograft Tolerance
X. Xiao
Surgery, Houston Methodist Hospital, Houston, TX
*Purpose: Infiltration of allografts by inflammatory macrophages is frequently associated with chronic graft loss In both animal models and clinical settings, but the mechanisms that…
2022 American Transplant Congress
Multiplexed Droplet Single-Cell Sequencing (mux-seq) Identifies Novel Cell States in Renal Allograft Rejection
P. Rashmi, S. Sur, T. Sigdel, P. Boada, M. Sarwal
UCSF, San Francisco, CA
*Purpose: Maintenance of systemic homeostasis by kidney requires the coordinated response of diverse cell types. Use of single-cell RNA sequencing (scRNAseq) for patient samples remains…
2022 American Transplant Congress
FasL-Presenting PEG Microgels Supports Sustained Graft Survival in Nonhuman Primates in the Absence of Continuous Immunosuppression
E. S. Yolcu¹, J. Lei², M. M. Coronel³, H. Deng⁴, Z. Yang⁴, A. Zhang⁴, T. Chen⁵, K. Lee⁴, C. Peters⁴, I. Rosales⁴, Z. Wang⁴, J. Markmann⁴, A. Garcia³, H. Shirwan¹
¹University of Missouri at Columbia, Columbia, MO, ²Surgery, Mass General, Boston, MA, ³Georgia Institute of Technology, Atlanta, GA, ⁴Massachusetts General Hospital, Boston, MA, ⁵Xiamen University Medical School, Xiamen, China
*Purpose: Broad application of allogeneic islets for T1D treatment is curtailed by the use of chronic immunosuppression to control rejection. Teff cells are the major…
2022 American Transplant Congress
Prediction of Waitlist Mortality in Liver Transplant Candidates: Do Time-Varying Models Help?
A. Kwong¹, W. Kim¹, D. Schladt², A. Wey², J. Snyder², A. Israni², J. Lake³
¹Stanford University, Stanford, CA, ²Hennepin Healthcare Research Institute, Minneapolis, MN, ³University of Minnesota, Minneapolis, MN
*Purpose: In the United States, priority on the liver transplant waitlist is determined by the model for end-stage liver disease (MELD)-Na, a score composed of…
2022 American Transplant Congress
Glucose Variability in Kidney Transplantation: Pre-Transplant and Post-Transplant Continuous Glucose Monitoring
E. Jo¹, A. Han², S. Min², J. Ha³, H. Lee⁴, A. Cho⁵
¹Surgery, Seoul National University Hospital, Seoul, Korea, Republic of, ²Seoul National University College of Medicine, Seoul, Korea, Republic of, ³Seoul Nat'l Univ. College of Medicine, Seoul, Korea, Republic of, ⁴Seoul National University Hospital, Seoul, Korea, Republic of, ⁵Surgery, Seoul National University College of Medicine, Seoul, Korea, Republic of
*Purpose: Continuous glucose monitoring (CGM) provides a 24-hour view of glucose values and information on glycemic variability and additional indices such as the glucose management…