Abstracts Archive - Page 1388 of 1683 - ATC Abstracts

2015 American Transplant Congress
Inverse Monocytic Subset Profile in Blood and Tissue During Heart Transplant Rejection
T. van den Bosch,¹ M. Kraaij,¹ K. Caliskan,² A. Constantinescu,² O. Manintveld,² P. Leenen,³ C. Baan,¹ M. van Groningen,⁴ A. Rowshani.¹
¹Department of Internal Medicine, Section Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, Netherlands; ²Department of Cardiology, Erasmus Medical Center, Rotterdam, Netherlands; ³Department of Immunology, Erasmus Medical Center, Rotterdam, Netherlands; ⁴Department of Pathology, Erasmus Medical Center, Rotterdam, Netherlands.
Introduction: Increased monocytic infiltration of heart transplant tissue is documented during acute rejection. It is still unclear how changes in circulating monocyte pool relate to…
2015 American Transplant Congress
Recipient Immunity to Murine Cytomegalovirus Influences Natural Killer Cell Responses in Infected Renal Allografts
M. Shimamura,¹ M. Li,¹ B. Chen,² J. George.²
¹Pediatric Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL; ²Cardiothoracic Surgery, University of Alabama at Birmingham, Birmingham.
BACKGROUND: Human cytomegalovirus (CMV) is associated epidemiologically with renal allograft loss, but the impact of recipient CMV immunity upon graft survival is unclear. Natural killer…
2015 American Transplant Congress
Immunological Aspects of Iron Overload in Heart and Kidney Transplantation
T. Resch,¹ S. Ebner,¹ P. Ritschl,¹ M. Ashraf,¹ C. Fabritius,¹ A. Brunner,² V. Nguyen,¹ J. Günther,¹ J. Pratschke,³ K. Kotsch.¹
¹Department of Surgery, Medical University Innsbruck, Innsbruck, Austria; ²Department of Pathology, Medical University Innsbruck, Innsbruck, Austria; ³Department of Surgery, Charité, Berlin, Germany.
Background: Clinical data suggest that iron (Fe) overload deleteriously affects graft survival after heart (HTX) and kidney transplantation (KTX) but possible immunologic mechanisms underlying this…
2015 American Transplant Congress
Epigenetic Reprogramming of Murine Cytomegalovirus Immediate Early Genes Induced By Renal Transplantation
M. Hummel,¹ X.-F. Liu,¹ C. Jie,¹ Z. Zhang,¹ S. Yan,¹ J.-J. Wang,¹ S. Kurian,² D. Salomon,² M. Abecassis.¹
¹Comprehensive Transplant Center, Northwestern University, Chicago, IL; ²Dept of Molecular and Experimental Medicine, The Scripps Research Institute, LaJolla, CA.
Background: Reactivation of latent CMV is a significant infectious complication in solid organ transplant recipients. MCMV is a valuable model for studying molecular mechanisms controlling…
2015 American Transplant Congress
Increased Precentage of Circulating CD16+ Monocytes Before Transplantation Are Associated With the Occurence of Acute Rejection
T. van den Bosch,¹ L. Hilbrands,² M. Kraaij,¹ E. Vereyken,¹ P. Leenen,³ D. Hesselink,¹ C. Baan,¹ A. Rowshani.¹
¹Department of Internal Medicine, section Nephrology and Kidney Transplantation, Erasmus Medical Center, Rotterdam, Netherlands; ²Department of Nephrology, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands; ³Department of Immunology, Erasmus Medical Center, Rotterdam, Netherlands.
Introduction: Monocytes compose a neglected immune cell type in transplantation despite their contribution to antibody mediated rejection. We aimed to define the phenotypic and functional…
2015 American Transplant Congress
Depression of Complement Regulatory Factors in Human and Rat Renal Grafts in Association With Progress of Acute Cellular Rejection
K. Yamanaka,^１ T. Kato,^１ Y. Kakuta,¹ T. Abe,¹ R. Imamura,¹ A. Maeda,² S. Miyagawa,² N. Nonomura.¹
¹Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; ²Organ Transplantation, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Introduction and ObjectiveIt is commonly known that complements play important roles in antibody mediated rejection in renal transplantation. However, the association of complements with progression…
2015 American Transplant Congress
Not Only CD28null But Also CD28pos T Cells Contribute to Rejection During Belatacept Treatment
G. de Graav,¹ D. Hesselink,¹ R. Kraaijeveld,¹ M. Dieterich,¹ W. Weimar,¹ M. Clahsen-Van Groningen,² C. Baan.¹
¹Internal Medicine, Erasmus Medical Center, Rotterdam, South Holland, Netherlands; ²Pathology, Erasmus Medical Center, Rotterdam, South Holland, Netherlands.
To explain the underlying immunological mechanisms for rejection under belatacept treatment, the phenotypical and functional characteristics of graft infiltrating lymphocytes were studied during rejection under…
2015 American Transplant Congress
Can MitoQ Improve Renal and Mitochondrial Function Following Cold Storage and Transplantation?
L. MacMillan-Crow,¹ N. Parajuli,¹ D. Borja-Cacho.
¹Pharmacology/Toxicology, Univ. of Arkansas for Medical Sciences, Little Rock, AR; ²Surgery, Univ. of Arkansas for Medical Sciences, Little Rock, AR.
The overall goal of this study is to further evaluate the effectiveness of a potential new therapy designed to minimize damage during cold preservation, increase…
2015 American Transplant Congress
Glucose Chemical Exchange Saturation Transfer MRI of Acute Renal Allograft Rejection
D. Kentrup,¹ A. Busch,² H. Pawelski,¹ V. Hoerr,^2,3 S. Reuter.¹
¹Department of Medicine D, University Hospital Münster, Münster, Germany; ²Department of Clinical Radiology, University Hospital Münster, Münster, Germany; ³Institute of Medical Microbiology, Jena University Hospital, Jena, Germany.
Purpose: During acute rejection episodes large amounts of immune cells infiltrate renal grafts, leading to inflammation accompanied by an increased glucose metabolism.Given these circumstances we…
2015 American Transplant Congress
Complement Inhibition Via the Lectin Pathway Improves Experimental Cardiac Graft Survival
J. Kindermann,^1,2 M. Waechter,^1,2 R. Bruno,¹ M. Langenmayer,³ T. Dudler,⁴ W. Schwaeble,⁵ E. Kleinert,¹ T. Mayr,^1,2 H. Christian,² R. Wanke,³ J.-M. Abicht,⁶ S. Guethoff.¹
¹Transregio Collaborative Research Center 127, Ludwig-Maximilians University, Munich, Germany; ²Department of Cardiac Surgery, Ludwig-Maximilians University, Munich, Germany; ³Institute of Veterinary Pathology, Ludwig-Maximilians University, Munich, Germany; ⁴Omeros Corporation, Seattle, WA; ⁵Department of Infection, Immunity, and Inflammation, Leicester University, Leicester, United Kingdom; ⁶Department of Anaesthesiology, Ludwig-Maximilians University, Munich, Germany.
Purpose: While complement activation via both the classical as well as the lectin pathway is believed to contribute to allograft loss, their relative contribution is…