Abstracts Archive - Page 1384 of 1683 - ATC Abstracts

2015 American Transplant Congress
Liver Allograft Utilization Within the United States: 2003-2013
J. Renz,¹ G. Diaz,¹ L. Ratner,² H. Yersiz,³ M. Millis,¹ J. Matthews.¹
¹Department of Surgery, University of Chicago, Chicago, IL; ²Department of Anesthesia/Critical Care, University of Chicago, Chicago, IL; ³Department of Surgery, Columbia University, New York, NY; ⁴Department of Surgery, University of California Los Angeles, Los Angeles, CA.
Objectives: 1) Evaluate liver allograft availability, utilization, and failure probability utilizing the liver donor risk index(LDRI) 2) Correlate allograft utilization with waitlist mortality and incidence…
2015 American Transplant Congress
CD28-Directed Therapy Prolongs Survival in a Non-Human Primate Kidney Transplant Model
L. Higginbotham,¹ D. Mathews,¹ C. Breeden,¹ W. Wakwe,¹ C. Larsen,¹ S. Nadler,² A. Adams.¹
¹Emory Transplant Center, Emory University School of Medicine, Atlanta; ²Bristol-Myers Squibb, Princeton.
Introduction. Costimulation blockade using belatacept has the potential to improve long-term renal function and reduce cardiovascular risk by avoiding calcineurin inhibitors, yet higher rates and…
2015 American Transplant Congress
Selective Blockade of the CD28/B7/CTLA4 Pathway With Monovalent Anti-CD28 Antibodies Versus Targeting of B7 With CTLA4-Ig, in Non-Human Primate Kidney Allograft
S. Ville,¹ N. Poirier,^1,2 B. Vanhove,^1,2 G. Blancho.¹
¹INSERM, UMR1064, ITUN, Nantes, France; ²Efﬁmune SAS, Nantes, France.
B7 molecules on antigen-presenting cells interact with CD28 and CTLA4 on T lymphocytes to control TCR-mediated signals. Whereas it is highly efficient to block T…
2015 American Transplant Congress
Impact of Human Mutant TGF-β1/Fc Protein On Memory and Regulatory CD4+T Cells Following Lymphodepletion in Rhesus Monkeys
H. Guo,¹ L. Lu,¹ R. Wang,² H. Abdulkerim,² R. Keith,² A. Thomson,¹ M. Ezzelarab.¹
¹Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA; ²MassBiologics, University of Massachusetts Medical School, Boston, MA.
Background:Tolerance to allografts is essential to avoid chronic immunosuppression and to promote long term graft function. Transforming growth factor- β plays a key role in…
2015 American Transplant Congress
Effects of Late Kidney Graftectomy in Nonhuman Primates (NHPs) Tolerant of Co-Transplanted Heart and Kidney Allografts
M. Tonsho,¹ G. Benichou,¹ R. Smith,² R. Colvin,² J. Madsen.^1,3
¹MGH Transplant Center, Massachusetts General Hospital, Boston, MA; ²Pathology, Massachusetts General Hospital, Boston, MA; ³Cardiac Surgery, Massachusetts General Hospital, Boston, MA.
Co-transplantation of donor kidneys and bone marrow enables the induction of tolerance of allogeneic hearts in NHPs. We have previously demonstrated that the state of…
2015 American Transplant Congress
Costimulation Blockade and Bortezomib to Desensitize Rhesus Macaque and Prolong Renal Allograft Survival
J. Kwun, C. Burghuber, E. Page, A. Gibby, N. Iwakoshi, S. Knechtle.
Surgery, Emory Transplant Center, Atlanta, GA.
[Background] Preformed donor specific antibody (DSA) due to prior sensitization affects a significant population of transplant patients, portending a poorer prognosis in short- and long-term…
2015 American Transplant Congress
Extended Life-Supporting Xenogeneic Lung Function With Multi-Transgeneic Donor Pigs and Targeted Drug Treatments
L. Burdorf,¹ E. Rybak,¹ T. Zhang,¹ D. Harris,¹ S. Dahi,¹ N. Kubicki,¹ D. Parsell,¹ E. Sievert,¹ D. Ayares,² A. Azimzadeh,¹ R. Pierson III.¹
¹University of Maryland, Baltimore; ²Revivicor, Blacksburg.
Purpose: Prolonged life-supporting (LS) xenolung function has proven difficult to accomplish. Here we report results from 21 xLTXs in a rigorous, LS pig-to-baboon model, asking…
2015 American Transplant Congress
Immunosuppression With Anti-CD40 mAb and Rapamycin for Islet and Kidney Co-Transplantation in Nonhuman Primates
T. Oura, K. Hotta, J. Lei, J. Markmann, A. Dehnadi, G. Benichou, B. Cosimi, T. Kawai.
Transplant Center, Massachusetts General Hospital, Boston, MA.
Background: For patients with end-stage renal disease secondary to type 1 diabetes mellitus, islet and kidney co-transplantation can be an ideal transplant option. However, a…
2015 American Transplant Congress
Educating Hispanic ESRD Patients About Living Donation: Impact of a Brief Intervention
E. Alvaro, J. Siegel, J. Poulsen, E. O'Brien.
Psychology, Claremont Graduate University, Claremont, CA; Psychology, Claremont Graduate University, Claremont, CA; Transplantation, St. Vincent Medical Center, Los Angeles, CA; Psychology, Claremont Graduate University, Claremont, CA.
Purpose: This study was designed to enhance Hispanic ESRD patient knowledge, norm perceptions, and efficacy regarding discussions of living kidney donation.Methods: The study was a…
2015 American Transplant Congress
Intrapatient Variability of Tacrolimus Trough Levels and Outpatient Clinic Non-Attendance Rates Predict Poor Renal Allograft Survival
D. Goodall, M. Willicombe, A. McLean, D. Taube.
Imperial College Renal and Transplant Centre, Hammersmith Hospital, London, United Kingdom.
IntroductionNonadherence to immunosuppressive medication post renal transplant is an importnat risk factor for rejection and graft loss. In this study we assess the association between…