2015 American Transplant Congress
Innate Immune Memory to Allogeneic Non-Self
Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA.
A hallmark of adaptive immunity is the generation of long-lived, antigen-specific memory T, B, and NK lymphocytes that mount strong anamnestic (recall) responses to previously…2015 American Transplant Congress
Upregulation of Heart Transplant IL-33 Is Critical in Cardiac Tissue Repair
Starzl Transplantation Institute, Department of Surgery, Univ of Pittsburgh, Pittsburgh, PA.
Background: IL-33 is tissue-derived cytokine whose primary proposed function is to modulate immune responses when released during injury. Delivery of recombinant IL-33 protects cardiac allografts…2015 American Transplant Congress
Interleukin-1 Receptor Signaling by Graft Stromal Cells Regulates Donor-Reactive CD8 T Cell Responses to Cardiac Allografts
Allograft reperfusion induces inflammation that directs the infiltration of memory T cells into the allograft and their activation to express functions mediating graft injury. The…2015 American Transplant Congress
Distinct Role of Complement Receptors C5L2 and C5aR in Acute Kidney Injury and Renal Fibrosis
ObjectiveAcute kidney injury (AKI) is a relevant complication in solid organ transplantation with incidence rates of ∼50-75 % after lung- and heart transplantation. In addition,…2015 American Transplant Congress
Changes in Acceptances Patterns Under Share 35
University of Texas HSC, San Antonio, TX; UNOS, Richmond, VA.
The Share 35 policy was implemented June 2013 with intent of directing to livers to the sickest patients with the highest mortality and presumably shortest…2015 American Transplant Congress
MELD/PELD 35+ Candidates Benefit from Regional Sharing
Background: Based on a proposal from the Liver and Intestinal Organ Transplantation Committee, the OPTN implemented regional sharing for MELD/PELD 35+ candidates on June 18,…2015 American Transplant Congress
Organ Procurement Organization Level Changes in Liver Utilization After Share-35
Dept of Surgery, Johns Hopkins, Baltimore, MD.
The OPTN implemented Share-35 in June 2013 to increase regional sharing. Organ Procurement Organization (OPO)-level changes in utilization subsequent to Share-35 have not previously been…2015 American Transplant Congress
Regional Mismatch Between Liver Supply and Demand: An Argument for a More Open Market
Background: Geographic disparities in liver transplantation (LT) are well recognized. But the degree to which regional variation in deceased donor deficits contributes to wait-list mortality…2015 American Transplant Congress
Geographic Variation in Listing Practices Represents Competetive Behaviors and Access to Care Rather Than Differences in Demand for Liver Transplantation
Purpose: This study evaluates whether program and patient demographics influence liver transplant listing practices.Methods:2013 liver waiting list and transplant (Tx) variables, US Census socioeconomic variables,…2015 American Transplant Congress
Regional Variations: Liver Transplant Tourism Within the US
Aim: Given the current geographic disparities in average MELD scores at liver transplantation (OLT), there is increasing interest in patients who travel for OLT and…
American Transplant Congress abstracts