Abstracts Archive - Page 1382 of 1683 - ATC Abstracts

2015 American Transplant Congress
Relationship Between Delayed Graft Function (DGF) Severity and Predicted DGF Risk
E. Squiers,¹ B. Irish,¹ D. Odenheimer,¹ S. Erlich,¹ J. Grinyo, S. Feng, On Behalf of Quark DGF Study Investigators.
¹Quark, Fremont; ²UCSF, SF; ³U of Barcelona, BCN, Spain.
Historically, dialysis required in the first post-transplant (TX) week has defined DGF. This incidence-based definition fails to discriminate between short versus long courses of dialysis…
2015 American Transplant Congress
Hypothermic Machine Perfusion Improves Kidney Viability through Amelioration of Vasospasm and Edema of Podocytes and Renal Tubular Epithelial Cells
Z. Zhong,¹ Z. Liu,¹ Z. Fu,² Y. Zhang,² D. Ko,³ Y. Wang,¹ Q. Ye.^1,2
¹Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, China; ²The 3rd Xiangya Hospital of Central South University, Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology, Changsha, Hunan, China; ³Massachusetts General Hospital, Department of Urology, Boston, MA.
Hypothermic machine perfusion (MP) may improve outcome after transplantation from donors after cardiac death (DCD) kidneys, but protective mechanisms of MP remain largely unknown. To…
2015 American Transplant Congress
A Prospective Comparison of the Completeness of Donor Kidney Biopsies
S. Ahmad,¹ E. Siskind,¹ C. Drachenberg,² J. Bromberg,¹ S. Niederhaus.¹
¹Transplantation, University of Maryland, Baltimore; ²Pathology, University of Maryland, Baltimore.
Background: The use of expanded criteria kidneys has plateaued, possibly due to inadequate pathologic evaluation or lack of a universal grading system. We examined pre-transplant…
2015 American Transplant Congress
Resolution of Glomerular Fibrin Thrombi in Deceased Donor Kidneys
R. Batra,¹ M. Smith,³ L. Thomas,² H. Khamash,² A. Moss,² J. Huskey,² A. Singer,¹ A. Mathur,¹ N. Katariya,¹ K. Reddy,¹ R. Heilman.²
¹Transplant Surgery, Mayo Clinic, Phoenix, AZ; ²Transplant Nephrology, Mayo Clinic, Phoenix, AZ; ³Pathology, Mayo Clinic, Phoenix, AZ.
BackgroundDeceased donor kidneys with Glomerular Fibrin Thrombi (GFT) are frequently discarded, but these kidneys may offer an opportunity to increase deceased donor organs. Our aim…
2015 American Transplant Congress
Excellent Outcomes With Deceased Donor Kidney Transplants With a Terminal Creatinine >= 3
L. Matsuoka,¹ E. Alicuben,¹ K. Woo,¹ H. Shidban,¹ Y. Qazi,² M. Smogorzewski,² S. Alexopoulos.¹
¹Department of Surgery, USC Keck School of Medicine, Los Angeles, CA; ²Department of Nephrology, USC Keck School of Medicine, Los Angeles, CA.
Purpose: Kidneys from deceased donors with elevated creatinine are frequently discarded due to concerns about poor post-transplant outcomes. In this study we sought to determine…
2015 American Transplant Congress
Biomarkers of Deceased Donors for the Prediction of Renal Allograft Outcomes
S. Kang,¹ H. Im,¹ J. Lee,¹ T. Koo,¹ S. Lee,² S. Park,³ S.-J. Kim,⁴ C. Ahn,¹ J. Yang.¹
¹Transplantation Center, Seoul National University Hospital, Seoul, Republic of Korea; ²Chonbuk National University Hospital, Jeonju, Republic of Korea; ³Inje University Busan Paik Hospital, Busan, Republic of Korea; ⁴Samsung Medical Center, Seoul, Republic of Korea.
Background: Better prognostic markers in deceased donors(DD) are needed for determining whether to accept suboptimal DD kidneys or predicting post-transplant outcomes. Recently, neutrophil gelatinase-associated lipocalin(NGAL),…
2015 American Transplant Congress
Gender Differences in Kidney Transplant Delayed Graft Function Are Independent of Donor-Recpient Size Mismatch
M. Levine,¹ A. Thomasson,¹ D. Aufhauser,¹ R. Redfield,² P. Abt,¹ P. Reese.³
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Surgery, University of Wisconsin, Madison, WI; ³Medicine, University of Pennsylvania, Philadelphia, PA.
Introduction: Superior female tolerance of ischemia reperfusion injury (IRI) relative to males has been described in animal models, but little human data are available to…
2015 American Transplant Congress
Recipient IL-33 Promotes Type 1 Alloimmunity and Lethal Acute GVHD Following alloHCT
B. Matta,¹ D. Reichenbach,² V. Schwarze,³ V. Tkachev,⁴ L. Mathews,¹ Q. Liu,¹ M. Warncke,⁵ J. Ferrara,⁴ R. Zeiser,³ B. Blazar,² H. Turnquist.¹
¹Surgery, Univ. of Pittsburgh, Pittsburgh, PA; ²Pediatrics, Univ. of Minnesota, Minneapolis, MN; ³Hematology and Oncology, Univ. Medical Center Freiburg, Freiburg, Germany; ⁴Pediatrics, Univ. of Michigan, Ann Arbor, MI; ⁵Novartis Institute for Biomedical Research, Basel, Switzerland.
Background: Graft-versus-host disease (GVHD) is a common complication of allogeneic (allo) hematopoietic cell transplantation (HCT) that limits its widespread application for the induction of transplant…
2015 American Transplant Congress
Targeted Silencing of TLR Adaptor Genes Using Mannose Liposome to Prolong Cardiac Allograft Survival
X. Zhang,¹ J. Jiang,² X. Zheng,¹ J. Shi,³ T. Zwiep,¹ N. Johnston,¹ D. Quan,^1,2 W.-P. Min.^1,2,3
¹Department of Surgery, Pathology and Oncology, Western University, London, ON, Canada; ²Multi-Organ Transplant Program, London Health Sciences Centre, London, ON, Canada; ³Jiangxi Academy of Medical Sciences, The First Affiliated Hospital, and Institute of Immunotherapy of Nanchang, NanChang, Jiangxi, China.
Background: MyD88 and TRIF, the common adaptors of Toll-like receptors (TLRs) signaling, evoke dendritic cells (DCs)-mediated antigen-specific immune rejection. Abolish TLR-induced adaptive immune response in…
2015 American Transplant Congress
Effects of Toll Like Receptor (TLR) Signaling on Murine Alloimmunity Are Modulated by Immune Cell Derived Complement
J. Sheen, P. Heeger.
Translational Transplant Research Center, Department of Medicine and Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
TLR signals prevent CD40L-blockade (MR1) induced murine transplant tolerance but mechanisms are incompletely understood. Based on previous findings that immune cell derived complement activation products…