2015 American Transplant Congress
Is BK Viral Subtype Distribution of Donor And/Or Recipient Important for Subsequent BK Viral Infection After Living-Donor Transplantation?
Background: Source and risk factors for developing BK virus (BKV) infection after renal transplantation are unresolved. By genotyping of urine and blood, we looked for…2015 American Transplant Congress
Impact of Donor and Recipient BKV Serostatus and the Effect of Ciprofloxacin Prophylaxis on BK Viremia Risk After Kidney Transplant
Background: BK virus (BKV) is a common infection in kidney transplant recipients. Due to widespread latent BKV infection in the general population, it is possible…2015 American Transplant Congress
T Cell Receptor Repertoire Analysis of BKV-Specific T Cells in Peripheral Blood Samples By Next Generation Sequencing Reveals Differential Role and Kinetics of CD4 and CD8 T Cell Clones in Viral Control
Background:BKV-specific T cells play the crucial role in controlling virus reactivation and analyses of their frequencies have been previously performed in different studies. However, nothing…2015 American Transplant Congress
Everolimus Conversion to Treat BK Virus Infection in Kidney Transplant Recipients
IntroductionmTORi's reduce BKV large T antigen expression in vitro and are associated with lower rates of BKV infection in clinical studies.MethodsPilot single center, randomized, open-label…2015 American Transplant Congress
De Novo Donor Specific Antibody (DSA) After Treatment of BK Infection With Intravenous Immunoglobulin (IVIG)
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Introduction: The primary treatment for polyomavirus BK viral infection (BKV) is a reduction in immunosuppression exposure. However this can lead to rejection and development of…2015 American Transplant Congress
Blood Gene Expression Profiling in a Randomized Controlled Trial of rATG Vs. IL2RA Induction Reveals the Differences in Immune Impact and Mechanisms
1MUSC, Charleston, SC; 2Scripps Research Institute, La Jolla, CA.
We performed global gene expression profiling using microarrays on samples from a prospective, RCT designed to study the safety & efficacy of induction with antithymocyte…2015 American Transplant Congress
Small RNA Sequencing-Enabled Discovery of Circulating Extracellular MicroRNAs as Noninvasive Biomarkers of Liver Allograft Status
1Weill Cornell Medical Center, New York; 2Rockefeller University, New York.
MicroRNAs are ideal candidates as blood-based biomarkers. Comprehensive profiling of microRNAs is challenging. We overcame the existing challenges by developing robust protocols for isolation of…2015 American Transplant Congress
Anti-Donor T-Cell Immunity Is a Continuum Immune Process Favouring Subclinical Rejection After Kidney Transplantation
Subclinical T-cell mediated rejection (sc-TCR) accounts for a major cause of kidney allograft loss and is unexpectedly found in a rather important number of protocol…2015 American Transplant Congress
Application of Second Generation Sequencing and AlloAntibody Screening to the Organ Transplantation Arena
Over the last two decades, over 300,000 solid organ transplantations have been performed in the USA alone. While there has been considerable progress with immunosuppression…2015 American Transplant Congress
Differences in Genetic Variants That Influence Long-Term Graft Function Between Pancreas Transplant Donors and Recipients
Genetic variation in caveolin-1, involved in signal transduction and tissue fibrosis, within pancreas transplant donors has been previously shown to correlate with decreased long-term graft…
American Transplant Congress abstracts