ATC Abstracts

American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    Survival Benefit of Kidney Transplant Among HIV+ Waitlist Candidates

    J. Locke,1 S. Gustafson,2 C. Durand,3 J. Snyder,2 B. Shelton,1 R. Reed,1 P. MacLennan,1 S. Mehta,1 A. Nellore,1 D. Segev.2,3

    1University of Alabama, Birmingham, AL; 2Scientific Registry of Transplant Recipients (SRTR), Minneapolis Medical Research Foundation, Minneapolis, MN; 3Johns Hopkins University, Baltimore, MD.

    Chronic diseases, such as end-stage renal disease (ESRD), are now the leading causes of death among HIV+ patients. Multiple studies have demonstrated the efficacy of…
  • 2015 American Transplant Congress

    A Gene Expression Assessment for Improving Disease Activity and Stage in Heart ABMR

    A. Loupy, M. Racape, J. Reeve, J. Venner, S. Varnous, A. Gay, R. Guillemain, L. Hidalgo, C. Lefaucheur, X. Jouven, P. Bruneval, J. Duong, P. Halloran.

    Paris Transplant Group & ATAGC, Paris - Edmonton, France.

    BackgroundABMR is a major cause of heart transplant failure. The diagnosis of ABMR in heart transplantation is based on the 2013 ISHLT pAMR classification. We…
  • 2015 American Transplant Congress

    Designing a KDPI to Assess Live Donors and Compare Them to Deceased Donors

    A. Massie, D. Segev.

    Johns Hopkins, Baltimore.

    The Kidney Donor Profile Index (KDPI) is used to assess risk of deceased donor kidneys (DDKT) based on donor characteristics. No comparable index exists for…
  • 2015 American Transplant Congress

    Erythropoietin (EPO) Has Treg Sparing Immunosuppressive Effects On Human Alloreactive T Cells

    C. Purroy, P. Heeger, P. Cravedi.

    Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY.

    Extending previous work showing that EPO inhibits alloreactive effector T cell proliferation by uncoupling IL2 receptor signaling (JASN 2014), we tested the effects of EPO…
  • 2015 American Transplant Congress

    Immunological Characterization of Full Facial Transplant Recipients

    T. Borges,1 J. Azzi,1 S. Tullius,1 A. Chandraker,1 B. Pomahac,2 N. Najafian,1 L. Riella.1

    1Transplant Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston; 2Plastic Surgery, Boston.

    Background: Despite the skin being considered the most immunogenic of all human tissues, full facial transplantation (FFT) has become a life transforming procedure with encouraging…
  • 2015 American Transplant Congress

    Clinical and Immunological Update 15 Years After the First VCA – Subsequent Kidney Transplantation After a Bilateral Hand Transplant

    A. Weissenbacher,1 G. Pierer,2 M. Gabl,3 M. Ninkovic,1 T. Hautz,1 J. Grahammer,1 B. Zelger,4 B. Zelger,5 G. Brandacher,6 S. Schneeberger.1

    1Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria; 2Department of Plastic, Reconstructive and Aesthetic Surgery, Innsbruck Medical University, Innsbruck, Austria; 3Department of Traumatology, Innsbruck Medical University, Innsbruck, Austria; 4Department of Dermatology and Venerology, Innsbruck Medical University, Innsbruck, Austria; 5Institute of Pathology, Innsbruck Medical University, Innsbruck, Austria; 6Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.

    Background: We herein describe the long term outcome with emphasis on function, immunosuppression (IS), complication and side effects, histomorphology and graft vascular changes 15 years…
  • 2015 American Transplant Congress

    Peritransplant Costimulation Blockade and Rapamycin Therapy Induces Permanent Limb Allograft Survival

    L. Wang, A. Samanta, J. Huang, T. Bhatti, Z. Wang, R. Han, L. Levin, M. Levine, W. Hancock.

    CHOP/UPenn, Philadelphia.

    Aim: Using murine models, we sought to identify the mechanisms of responsible for vascularized composite allotransplant (VCA) rejection, and to thereafter, using clinically relevant peri-transplant…
  • 2015 American Transplant Congress

    Vascularized Bone Marrow Plays a Critical Role in Inducing Tolerance of Osteomyocutaneous Allografts

    C.-H. Lin,1 M. Anggelia,1 Y.-L. Wang,1 H.-Y. Cheng,1 W. Lee,2 G. Brandacher.2

    1Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Taipei, Taiwan; 2Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.

    Background: Vascularized composite allograft (VCA) that includes medullary bone may provide proposed benefits ofvascularized bone marrow transplantation (VBMT), such as a continuous supply of donor…
  • 2015 American Transplant Congress

    Concerted T-Cell Activity Against Early and Late BKV-Antigens Is Necessary for Viral Clearance

    B. Weist,1,2 M. Schmueck,2 M. Dziubianau,2 P. Reinke,1,2 N. Babel.1,2

    1Department of Nephrology, Charite Universitaetsmedizin, Berlin, Germany; 2BCRT, Charite Universitaetsmedizin, Berlin, Germany.

    Polyomavirus-BK (BKV) associated nephropathy is a known cause of graft failure. No specific therapy is established so far and viral load monitoring accompanied by adjustment…
  • 2015 American Transplant Congress

    Clinically Relevant Anti-TCR mAb Induction Plus Brief Rapamycin Therapy Can Achieve Long-Term Vascularized Composite Allograft (VCA) Survival

    L. Wang, A. Samanta, J. Huang, T. Bhatti, Z. Wang, R. Han, L. Levin, M. Levine, W. Hancock.

    CHOP/UPenn, Philadelphia.

    Aim: Current strategies for management of VCA recipients are adapted from solid organ transplant protocols, and almost universally employ induction therapy followed by maintenance triple…
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