2015 American Transplant Congress
LFA-1 Is Crucial for Germinal Center Reconstruction After T cell Depletion and IL-21 Biased Antibody-Mediated Rejection
1Surgery, Emory Transplant Center, Atlanta, GA; 2Surgery, Duke University, Durham, NC.
[Background] Lymphocyte depletion prior to transplantation is beneficial in reducing initial maintenance immunosuppression in transplantation. However, despite its excellent efficacy in controlling T cell mediated…2015 American Transplant Congress
Germinal Centre Autoimmunity Mediates Progression of Allograft Vasculopathy, With Essential Help Provided By T Follicular Cells
Dept of Surgery, University of Cambridge, Cambridge, United Kingdom.
Introduction: : In our previous work we have shown that donor CD4 T cells within heart grafts initiate anti-nuclear autoantibody responses. Here we clarify the…2015 American Transplant Congress
BAFF Binding to T Cell-Expressed BAFF-R Promotes Follicular Helper T Cell Proliferation and GC B Cell Responses
Recent studies have defined a crucial role for the B cell–activating factor belonging to TNF family (BAFF) in promoting germinal center (GC) responses in mouse…2015 American Transplant Congress
In Vitro Evidence That CTLA4Ig Attenuates Recall Alloantibody Responses
Background: CTLA4Ig is an agonist that blocks CD28-B7 costimulation, downregulating T cell immunity, but also appears to negate T cell-dependent B cell activation, thus inhibiting…2015 American Transplant Congress
Blocking CD4 T Cell Helper Functions Improves Efficacy of ATG Treatment in Sensitized Transplant Recipients
Immunology, Cleveland Clinic, Cleveland, OH.
Antibody mediated lymphocyte depletion is used in clinical transplantation to improve graft function. While the presence of donor-reactive memory T cells is the primary rationale…2015 American Transplant Congress
Comparison of Efficacy of Prophylactic Antivirus Therapies on Outcomes of Kidney Transplantation in Hepatitis B Virus Carriers
Purpose To compare the efficacy between entecavir and lamivudine as prophylactic antivirus therapy on long-term outcomes of HBV carriers after kidney transplantation.Methods We retrospectively reviewed…2015 American Transplant Congress
Pharmacoepidemiology of Cytomegalovirus Prophylaxis in a Large Multicenter Cohort of Kidney Transplant Recipients
Washington University School of Medicine, Saint Louis, MO.
Background: Cytomegalovirus (CMV) prophylaxis or preemptive treatment are recommended for seronegative recipients of kidneys from seropositive donors (D+/R-) and seropositive patients (R+), but not D-/R-…2015 American Transplant Congress
Analysis of In-Vitro Effects of Immunosuppression on NK Cell Subsets in the Presence of Cytomegalovirus
Background: NK cells may play an important role in the control of CMV replication post-transplant. NK cells can be divided into subsets based on surface…2015 American Transplant Congress
Incidence of CMV Viremia in Obese and Morbidly Obese Kidney Transplants Under a Low Dose Valganciclovir Prophylaxis Protocol
1Pharmacy Practice, Univ of IL-Chicago, Chicago, IL; 2Surgery, Univ of IL-Chicago, Chicago, IL.
Background: The rate of Cytomegalovirus infections in kidney transplant recipients drastically diminished with the advent of oral ganciclovir and subsequently valganciclovir. However it continues to…2015 American Transplant Congress
Norovirus Infection in Renal Transplant Recipients – Clinical Severity and Genotype Identification
Introduction: Norovirus (NoV) is increasingly recognized as causative agent of gastro-enteritis in renal transplant recipients.Methods: We performed a retrospective study (2003-2012) to investigate the clinical…
American Transplant Congress abstracts