ATC Abstracts

American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    ALDH Expression in Facilitating Cells Plays a Critical Role in Regulatory T Cell Induction and GVHD Prevention

    H. Xu,1 T. Miller,1 Y. Huang,1 S. Ildstad.1,2

    1Institute for Cellular Therapeutics, University of Louisville, Louisville, KY; 2Regenerex, LLC, Louisville, KY.

    Graft-vs-host disease (GVHD) is a major source of morbidity in hematopoietic stem cell transplantation (HSCT), limiting its application to treat nonmalignant hematopoietic diseases and to…
  • 2015 American Transplant Congress

    Noncanonical Anergic Alloreactive B Cells in Transplantation Tolerance

    J. Chen, M. Daniels, D. Yin, R. Sciammas, A. Chong.

    Depart of Surgery, University of Chicago, Chicago.

    The observation that operationally tolerant patients (TOL) display higher numbers of blood B cells and a B cell gene signature compared to stable kidney allograft…
  • 2015 American Transplant Congress

    TGFβ Production By B Cells Is Critical for Transplant Tolerance Induction

    J. Kim,1 W. Liu,1,2 L. Liu,1,2 K. Lee,1 R. Stott,1 H. Yeh,1 J. Markmann.1

    1Surgery, Massachusetts General Hospital / Harvard Medical School, Boston, MA; 2Surgery, Chengdu Military General Hospital, Chengdu, Sichuan, China.

    Regulatory B cells (Bregs) have been shown to play a critical role in immune homeostasis and in autoimmunity models. We have recently demonstrated that combined…
  • 2015 American Transplant Congress

    TIM-4 Identifies IL-17 Expressing Pro-Inflammatory Be-17 Cells That Promote Allograft Rejection

    Q. Ding, K. Mohib, D. Rothstein.

    Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA.

    We identified TIM-1 as an inclusive marker for IL-10+ regulatory B cells (TIM-1+ Bregs), which prolong islet allograft survival (GS). We recently found that TIM-4,…
  • 2015 American Transplant Congress

    Controlling Alloreactive B Cell Responses in Sensitized Recipients With CTLA-4Ig

    J. Chen,1 Q. Wang,1 D. Yin,1 V. Vu,1 R. Sciammas,2 A. Chong.1

    1Depart of Surgery, University of Chicago, Chicago; 2Immunobiology Transplant Center, Houston Methodist Research Institute, Houston.

    Sensitized recipients are defined by the presence of pre-transplant donor-specific antibodies and have significantly poorer graft outcomes compared to unsensitized recipients despite efforts to desensitize.…
  • 2015 American Transplant Congress

    The Spleen Is the Primary Site for Breg Induction and Is Required for Anti-TIM-1 Mediated Tolerance

    K. Mohib, Q. Ding, A. Cherukuri, D. Rothstein.

    Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA.

    B cells can exhibit potent IL-10-dependent regulatory (Breg) activity. IL-10-enriched Bregs can transfer tolerance in auto and allo-immune models. We showed that TIM-1 is an…
  • 2015 American Transplant Congress

    Hepatic Stellate Cells Directly Inhibit B Cells Via PD-L1

    Y. Li, K. Fang, S. Qian, J. Fung, L. Lu, F. Lin.

    Immunology, Lerner Research Institute; 2General Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH.

    Hepatic stellate cells (HSCs) account for one third of the nonparenchymal cells in the liver, which are considered to be critical in maintaining the immunoprivileged…
  • 2015 American Transplant Congress

    B Cell Depletion With an Anti-CD20 Antibody Enhances Alloreactive Memory T Cell Response After Transplantation

    J. Marino, P. Crosby Bertorini, J. Paster, A. Trowell, K. Briggs, L. Maxwell, G. Benichou.

    Surgery Department, Center for Transplantation Sciences, Massachusetts General Hospital / Harvard Medical School, Boston, MA.

    Pre-transplant B cell depletion in NHP with Rituximab (IgG1 anti-CD20 mAb) combined with cyclosporin A has been shown to promote the survival of islets allografts.…
  • 2015 American Transplant Congress

    Inhibition of RhoA Pathway-Related Macrophage Functions Abrogates Chronic Rejection of Cardiac Allograft

    M. Kloc, J. You, N. Tejpal, X. Li, R. Ghobrial.

    TMHRI, Houston, TX.

    Objective. Chronic rejection remains the main obstacle in the long-term success of organ transplantation. The long-term survival of allografted hearts is limited by a progressive…
  • 2015 American Transplant Congress

    Role of Innate Immune Cells in Chronic Allograft Loss and Novel Strategies to Target Them

    C. Wu,1,2 P. Zhao,1 W. Liu,1 X. Xiao,1 X. Shi,1 Y. Peng,1 M. Kloc,1 X. He,2 M. Ghobrial,1 X. Li.1

    1Center for Immunobiology and Transplantation Research, Houston Methodist Hospital and Houston Methodist Research Institute, Houston, TX; 2Organ Transplant Center, 1st Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.

    Despite remarkable improvements in short term transplant survival, the long-term outcome of allografts remains poor in the clinic, and most transplants are eventually lost due…
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