2016 American Transplant Congress
Outcomes Associated with Carbapenem-Resistant Enterobacteriaceae Infection After Solid Organ Transplantation in a Multicenter Study.
BackgroundCarbapenem-resistant Enterobacteriaceae infection (CREI) is associated with poor outcomes in solid organ transplant (SOT) recipients but most reports are single center experiences.MethodsPatients who underwent SOT…2016 American Transplant Congress
Rituximab Induction in Cardiac Transplantation Is Associated with Accelerated Coronary Artery Vasculopathy: CTOT11.
On Behalf of the CTOT11 Consortium, Brigham & Women's Hospital, Boston, MA.
PurposeThe NIH-funded study CTOT11: Prevention of Cardiac Allograft Vasculopathy Using Rituximab (RIT) Therapy in Cardiac Transplantation, was a randomized clinical trial in non-sensitized primary heart…2015 American Transplant Congress
Differential Role of PI3K Subunits Gamma and Delta in Regulatory T Cells Homeostasis in Allotransplantation
Renal/Transplant Research Center, Brigham and Women's Hospital, Boston, MA.
Targeting survival pathways that differentially suppress effector T cells (Teff) while sparing regulatory T cells (Tregs) is key in devising novel tolerogenic protocols in transplantation.…2015 American Transplant Congress
Immune Reconstitution in Recipients of Living Donor Kidney/Hematopoietic Stem + Facilitating Cell Transplants
We report the long-term results from a reduced-intensity nonmyeloablative conditioning approach to establish high levels of donor chimerism without graft-versus-host disease (GVHD) in mismatched related…2015 American Transplant Congress
A Novel, Blocking Anti-CD40 Monoclonal Antibody Prolongs Non-Human Primate Renal Allograft Survival in the Absence of B-Cell Depletion Or Thromboembolic Events
Background. CD40-CD154 pathway blockade prolongs renal allograft survival in non-human primates (NHPs). However, antibodies targeting CD154 were associated with an increased incidence of thromboembolic complications…2015 American Transplant Congress
Why Are Pancreas Transplant Volumes Declining?
Background: Pancreas transplant volumes have been decreasing in the US since the mid-2000s. It has been conjectured that poor utilization of deceased donor pancreata (as…2015 American Transplant Congress
Is BMI of 28 an Appropriate Cutoff for Simultaneous Pancreas Kidney Transplant in Type II Diabetes?
Multi-Organ Transplant Institute, Ochsner Clinic Foundation, New Orleans, LA.
In simultaneous pancreas and kidney (SPK) transplantation, obesity has been reported to be associated with inferior survival and increased post-transplant complications. With implementation of the…2015 American Transplant Congress
Controlled DCD Pancreas Transplantation : A Single Centre Experience
Oxford Transplant Centre, Oxford University, Oxford, United Kingdom.
Background: The use of DCD pancreata are gaining popularity in the UK. Isolated pancreas transplantation (IP) is known to have inferior outcomes in comparison to…2015 American Transplant Congress
Invasive CMV-Infection of the Duodenal Cuff – An Underestimated Entity of CMV Infection and Its Potential Impact On Outcome After Pancreas Transplantation
IntroductionWe present data on the incidence of focal invasive CMV-infection of the duodenal cuff and its potential impact on clinical outcome after pancreas transplantation (PT).Material…2015 American Transplant Congress
Enhanced Production of Macrophage Chemoattractant Protein-1 (MCP-1) Within the Kidney in Brain Death Donors Predicts Recipient Allograft Function
Medicine/Surgery, University of Alabama at Birmingham, Birmingham, AL.
Brain death (BD) induces an intense pro-inflammatory state, which may impact recipient immunity and graft function after kidney transplantation. The identification of biomarkers predictive of…
American Transplant Congress abstracts