2016 American Transplant Congress
Expansion of Regulatory B-Cells and Their Potential Role in Transplantation Tolerance.
Massachusetts General Hospital, Boston, MA.
IntroductionRegulatory B (Bregs) cells, B cells which produce IL-10, have been shown to play a critical role in immune homeostasis and autoimmunity models. Despite the…2016 American Transplant Congress
Tracking Endogenous B Cells Recognizing Allogeneic MHC Class II in Mice.
Clinical data suggest that donor-specific antibody (DSA)-mediated rejection is currently the leading cause of kidney allograft failure, with anti-donor Class II Abs tending to be…2016 American Transplant Congress
Belatacept Does Not Inhibit Plasmablast Formation Supported by Follicular T Helper Cells, but Favors the Development of Transitional Regulatory B Cells in Kidney Transplant Patients.
Since the costimulatory inhibitor belatacept effectively blocks T-B cell interaction in animal transplant models, we studied the functional follicular T helper cells (TFH)-B cell interaction…2016 American Transplant Congress
Targeting IFN-g-Expressing TIM-4+ B Effector (Beff) Cells as a Novel Strategy to Prevent Allograft Rejection.
1University of Pittsburgh, Pittsburgh; 2Harvard Medical School, Boston.
B cell depletion can augment or inhibit auto- and allo- immune responses in humans and mice without altering Ig levels. This is likely due to…2016 American Transplant Congress
The Role of PI3kγ and PI3kδ in Alloimmunity.
We studied the role of phosphatidylinositol-3-kinases (PI3k) γ and δ pathway in alloimmunity. Generated Foxp3-GFP-PI3kγ and -PI3kδ knockout mice (C57BL/6 background) were used in heart…2016 American Transplant Congress
Transfer of Donor-Derived Exosomes to Recipient Ag-Presenting Cells Is Critical for Allograft Recognition.
After organ transplantation, T cells are primed against donor MHC molecules by donor dendritic cells (DCs) mobilized from the graft. Nevertheless, evidence suggests that donor…2016 American Transplant Congress
Inhibitory FcγRIIB Functionally Inhibits Donor-Reactive CD8+ Memory T Cell Responses Following Transplantation.
Emory Transplant Center, Emory University, Atlanta, GA.
Fc receptors are expressed by many types of immune cells and bind to the constant portion of immunoglobulin to mediate their effector functions. The inhibitory…2016 American Transplant Congress
NK-Activating MCMV Strain Is Associated with Increased Murine Renal Transplant Injury.
Background: CMV contributes to inferior longterm kidney transplant survival. In a murine model, NK cells infiltrate MCMV infected renal allografts in greater numbers than in…2016 American Transplant Congress
The 20S Proteasome, Active within Exosome-Like Vesicles Released by Apoptotic Cells Accelerates Rejection.
Apoptotic bodies (ApoBodies) and apoptotic exosome-like MV (ApoExo) released by apoptotic endothelial cells in vitro were purified by sequential centrifugation and analysed by electron microscopy…2016 American Transplant Congress
Blocking MHC Class II on Human Endothelium Mitigates Acute Rejection of Vessel Allografts by Effector Memory T Cells.
Acute allograft rejection is mediated by alloreactive CD8+ T cells that differentiate into cytotoxic lymphocytes (CTL). In most rodent models, CTL differentiate from naïve CD8+…
American Transplant Congress abstracts