2016 American Transplant Congress
Allo-Specific Memory B Cell Recall Responses Are Dependent on B Cell Autophagy.
B cells, and in particular, memory B cells (Bmem) are sources of donor specific antibodies (DSA) that cause allograft injury. Understanding requirements for Bmem function/survival…2016 American Transplant Congress
Designing and Synthesizing a Novel Highly Selective Immunoproteasome Inhibitor That Promotes Long Term Heart Allograft Acceptance While Reducing Plasma Cells and Donor Specific Antibodies.
Antibody mediated rejection (AMR) is one of the most important barriers to improving long-term transplant outcomes. Traditional therapies for AMR do not deplete the source…2016 American Transplant Congress
Selective Deletion of Notch2 on B Cells Abrogates Alloantibody Production in Fully MHC-Mismatched Cardiac and Skin Transplant Models.
Alloantibody-mediated injury remains a major challenge for the improvement of long-term graft survival and there is no effective therapy to prevent alloantibody generation post-transplant. The…2016 American Transplant Congress
CTLA4 Negatively Regulates Donor-Reactive CXCR5+PD1+ T Follicular Helper Cell Responses Following Transplantation.
1Emory Transplant Center, Atlanta; 2Bristol-Myers Squibb, Princeton.
Costimulation blockade of the CD28 pathway in the form of CTLA4Ig is known to attenuate T cell dependent antibody responses. T follicular helper (Tfh) cells…2016 American Transplant Congress
Differential Regulation of the Microvascular Endothelial Cell Mediated Allogeneic CD4+ T Cell Response by Anti-HLA-DR and -DQ Alloantibodies in an Inflammatory Context.
This study examines the basic mechanisms by which high levels of circulating HLA class II donor-specific-antibodies can contribute to microvasculature damage in chronic antibody mediated…2016 American Transplant Congress
NK Cells Play a Critical Role in Mediating Inflammation and Graft Failure During Antibody-Mediated Rejection of Kidney Allografts.
While the incidence of antibody-mediated kidney graft rejection has increased, the key cellular and molecular participants underlying this graft injury remain unclear. We have previously…2016 American Transplant Congress
Metallothionein Accelerates Anti-MHC Induced Small Airway Obliteration and Fibrosis by Negatively Regulating IL-10 and Regulatory Cells.
Development of bronchiolitis obliterans syndrome (BOS), chronic lung allograft rejection, is a major obstacle to long-term success from lung transplantation. De novo antibodies (Abs) to…2016 American Transplant Congress
Prolongation of Graft Survival by Anti-TIM1 Is Specifically Mediated by IL-10+ Bregs and Is Not Dependent on IL-35 or Plasma Cell Differentiation.
In B cell-deficient mice, prolonged islet allograft survival (GS) mediated by anti-TIM1 depends on transfer of IL-10 competent B cells. However, such regulatory B cells…2016 American Transplant Congress
Fate of Endogenous Alloreactive B Cells in Transplant Tolerance.
The conceptual underpinning of our studies is that robust tolerance requires multiple mechanisms to enforce functional quiescence of alloreactive T and B cells. While much…2016 American Transplant Congress
B Lymphocytes Prevent Transplantation Tolerance in NOD Mice by Limiting CD4 Treg Function.
Pediatrics, Vanderbilt University, Nashville, TN.
IntroductionType 1 Diabetes is a significant barrier to islet transplant as grafts are subject to both alloimmunity and recurrent autoimmunity. No better is this clinical…
American Transplant Congress abstracts