2016 American Transplant Congress
Impact of Early Hospital Readmission Following Simultaneous Pancreas Kidney Transplantation.
Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD.
BACKGROUND: Our group recently demonstrated that 54% of simultaneous pancreas kidney (SPK) recipients experience early hospital readmission (EHR). It is unknown whether EHR following SPK…2016 American Transplant Congress
Simultaneous Pancreas and Kidney Transplantation for Type 2 Diabetes.
Transplantation, California Pacific Medical Center, San Francisco, CA.
Introduction: Type 2 diabetes (T2DM) is characterized initially by insulin resistance and later by beta cell failure. Historically, T2DM has been a relative contraindication for…2016 American Transplant Congress
Donation After Cardiac Death Dose Not Impact Short and Long Term Graft Outcomes in Simultaneous Pancreas and Kidney Transplantation.
1Washington University in St. Louis, St. Louis; 2Saint Louis University, St. Louis.
Background:Organ donation after cardiac death (DCD) has the potential to expand the pool of available organs for transplantation. Because of the concern that warm ischemia…2016 American Transplant Congress
Rapamycin Encapsulated Nanoparticles as Pre-Treatment in Lung Transplantation.
Introduction: While short-term lung transplant outcomes have improved over the years, long-term survival rates remain stagnant. Many injuries occur to the donor organ before transplantation,…2016 American Transplant Congress
Receptor Tyrosine Kinase Mer Mediates Expansion of MDSCs Critical for Transplantation Tolerance.
Introduction: The TAM (Tyro3, Axl and Mer) receptor tyrosine kinases (RTKs) mediate homeostatic phagocytosis of apoptotic cells, and transmit regulatory signals that modulate immune response.…2016 American Transplant Congress
NK Cells Are Required in B-Cell Dependent, Antibody Mediated Islet Transplant Tolerance.
Dept of Surgery, Transplant Surgery Division, Massachusetts General Hospital, Boston, MA.
Immunologic tolerance to islets has been achieved in various rodent models using antibodies directed at CD45RB and Tim-1. We have shown that this tolerance mechanism…2016 American Transplant Congress
High PD-L1/CD86 MFI Ratio and IL-10 Secretion Characterize Maturation-Resistant Human Regulatory Dendritic Cells (DCregs) Generated for Clinical Testing in Transplantation.
Regulatory dendritic cells (DCregs) have shown considerable potential for safe and effective prolongation of allograft survival in pre-clinical models. In humans, DCregs with purity >84%…2016 American Transplant Congress
Long-Lasting Skin Allograft Tolerance Induced and Maintained by Short-Term Vascularized Bone Marrow Transplant in a Mouse Model.
Background: Accumulating evidences indicate that vascularized bone marrow transplantation (VBMT) plays a critical role in inducing tolerance of vascularized composite allografts (VCA). Recipients with long-term…2016 American Transplant Congress
A Novel Murine Orthotopic Forelimb Transplantation Model That Allows for Reliable Assessment of Post-Transplant Upper Extremity Function.
Background: Studies related to functional return for upper extremity transplantation have been limited by the lack of a functional VCA animal model. The rat hindlimb…2016 American Transplant Congress
TGFb in Regulatory B Cells-Dependent Tolerance.
Surgery, Massachusetts General Hospital, Boston, MA.
In transplantation, increasing evidence support that B cells can play a major regulatory role in addition to their critical functions in allo-immunity and graft rejection.…
American Transplant Congress abstracts